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1

The alterations in SATB1 and nuclear F-actin expression affect apoptotic response of the MCF-7 cells to geldanamycin

100%
Grzanka D., Izdebska M., Klimaszewska-Wisniewska A., Gagat M.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 1
2

The interactions between SATB1 and F-actin are important for mechanisms of active cell death

88%
Grzanka D., Kowalczyk A. E., Izdebska M., Klimaszewska- -Wisniewska A., Gagat M.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 2
3

Electron microscope study of the advanced tendinopathy process of the long head of the biceps brachii tendon treated arthroscopically

88%
Zabrzynski J., Gagat M., Paczesny L., Lapaj L., Grzanka D.
Folia Morphologica
|
2018
|
tom 77
|
nr 2
Background: The ultrastructural alterations related to tendinopathy have not been well described. Most studies on this subject have been conducted many years ago and focused on material from the Achilles tendon. It was demonstrated that various comorbidities can affect ultrastructural alterations in the advanced tendinopathy; however, there is very little data on ultrastructural morphology in tendinopathies related to mechanical overload as in case of the long head of the biceps brachii tendon (LHBT). The aim was to determine intermediate ultrastructural alterations in middle to severe grade the LHBT tendinopathy and to establish if they are different than those reported in the literature for other anatomical locations. Materials and methods: In this study we examined the ultrastructure of a series of the LHBT fragments arthroscopically removed due to tendinopathy and investigated the morphology of tenocytes and collagen fibres in cases of the LHBT tendinopathy. Results: In pathological samples tenocytes were randomly scattered, their shape was round and the shape of nuclei was also disrupted. The presence of apoptotic- -like features in tenocytes’ nuclei was noted. All samples showed replacement of collagen fibrils by non-collagen extracellular matrix and diffuse collagen disorganisation. Conclusions: It was demonstrated at ultrastructural level that the LHBT tendinopathy is not simply a wear and tear phenomenon, since chronic degeneration of the extracellular matrix and tenocytes were present, similarly as in tendinopathies, in other anatomical locations. (Folia Morphol 2018; 77, 2: 371–377)
4

Sonography in the instability of the long head of the biceps tendon confronted with histopathologic and arthroscopic findings

88%
Zabrzynski J., Paczesny L., Zabrzynska A., Grzanka D., Lapaj L.
Folia Morphologica
|
2018
|
tom 77
|
nr 3
Background: Disorders of the long head of the biceps (LHB) tendon are a common source of shoulder pain and disability. This tendon can be well visualised using ultrasonography; however, little is known if such examination allows clinicians to predict pathological changes of the tendon structure. In the study described below, we compare preoperative sonographic findings with the data from shoulder arthroscopy and microscopic examination of the excised tendon fragments in 19 consecutive patients with LHB tendinopathy and clinical suspicion of its instability. Materials and methods: Preoperative ultrasonographic (US) inspection assessed several features of the tendon, whereas its stability was verified arthroscopically. In all cases, tenodesis or tenotomy procedures were performed and excised tendon fragments were harvested for microscopic examination based on the semiquantitative Bonar score. Results: The most common US findings were hypoechoic areas, tendon thickening, an increased power Doppler signal and mechanical instability. Just as shoulder arthroscopy confirmed all mechanical instability cases detected in US, microscopic assessment revealed advanced degeneration in all samples. Conclusions: Our study indicates that US is a useful tool in identifying cases of advanced instability and LHB tendinopathy, whereas biceps tendon instability is a biomechanically complex, gradually progressing phenomenon, frequently associated with additional shoulder lesions. (Folia Morphol 2018; 77, 3: 583–590)
5

The role of exportin 6 in cytoskeletal-mediated cell death and cell adhesion in human non-small-cell lung carcinoma cells following doxorubicin treatment

88%
Izdebska M., Gagat M., Grzanka D., Halas M., Grzanka A.
Folia Histochemica et Cytobiologica
|
2014
|
tom 52
|
nr 3
6

Process of neovascularisation compared with pain intensity in tendinopathy of the long head of the biceps brachii tendon associated with concomitant shoulder disorders, after arthroscopic treatment. Microscopic evaluation supported by immunohistochemical markers of the endothelial cells

88%
Zabrzynski J., Paczesny L., Lapaj L., Grzanka D., Szukalski J.
Folia Morphologica
|
2018
|
tom 77
|
nr 2
Background: Tendinopathy of the long head of the biceps brachii tendon (LHBT) is one of the most common, painful conditions of the anterior part of the shoulder and often coexists with rotator cuff tears. Multifactorial aetiopathology of tendinopathy is poorly understood; however, several studies indicated that it is seen predominantly in areas with decreased vascularity of the tissue; the pathology is also characterised by expansive and abundant neovascular in-growth. The aim of the study was to investigate the relationship between the neovascularisation of proximal part of the LHBT and pain along the bicipital groove. Materials and methods: Tissue material was obtained from 28 patients who underwent a shoulder arthroscopy and experienced pain along the bicipital groove measured using Visual-Analog Scale (VAS) score. CD31 and CD34 molecules were visualised by immunohistochemical method to assess biceps tendon neovascularisation and quantify it based on a Bonar scoring system. Results: Although all patients reported pain prior to arthroscopy (mean VAS score was 7.5), microscopic examination did not reveal neovascularisation in all cases. Immunohistochemical staining for CD31 and CD34 allowed for very precise visualisation and quantification of neovascularisation; however there was also no correlation between vessels in-growth scores and pain. Conclusions: The obtained data suggest that neovascularisation process in tendinopathy is not directly related to pain; however, further studies are needed to explain its significance in the LHBT tendinopathy. (Folia Morphol 2018; 77, 2: 378–385)
7

Tendon — function-related structure, simple healing process and mysterious ageing

88%
Zabrzynski J., Lapaj L., Paczesny L., Zabrzynska A., Grzanka D.
Folia Morphologica
|
2018
|
tom 77
|
nr 3
Tendons are connective tissue structures of paramount importance to human ability of locomotion. The understanding of their physiology and pathology is gaining importance as advances in regenerative medicine are being made today. So far, very few studies were conducted to extend the knowledge about pathology, healing response and management of tendon lesions. In this paper we summarise actual knowledge on structure, process of healing and ageing of the tendons. The structure of tendon is optimised for the best performance of the tissue. Despite the simplicity of the healing response, numerous studies showed that the problems with full recovery are common and much more significant than we thought; that is why we discussed the issue of immobilisation and mechanical stimulation during healing process. The phenomenon of tendons’ ageing is poorly understood. Although it seems to be a natural and painless process, it is completely different from degeneration in tendinopathy. Recent studies of biological treatment reported faster and optimal healing of the tendons when augmented by growth factors and stem cells. Despite advances in biology of tendons, management of their injuries is still a challenge for physicians; therefore, further studies are required to improve treatment outcomes. (Folia Morphol 2018; 77, 3: 416–427)
8

Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells

88%
Izdebska M., Grzanka A., Ostrowski M., Zuryn A., Grzanka D.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 3
9

Nornicotine impairs endothelial cell-cell adherens junction complexes in the EA.hy926 cell line via structural reorganization of F-actin

88%
Gagat M., Grzanka D., Izdebska M., Maczynska E., Grzanka A.
Folia Histochemica et Cytobiologica
|
2013
|
tom 51
|
nr 3
10

Actin filament reorganization in HL-60 leukemia cell line after treatment with G-CSF and GM-CSF

88%
Grzanka A., Izdebska M., Litwiniec A., Grzanka D., Safiejko-Mroczka B.
Folia Histochemica et Cytobiologica
|
2007
|
tom 45
|
nr 3
11

Doxorubicin-induced F-actin reorganization in cofilin-1 (nonmuscle) down-regulated CHO AA8 cells

76%
Grzanka D., Marszalek A., Gagat M., Izdebska M., Gackowska L., Grzanka A.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 3
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