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BDNF proteolytic products: diversity of effects on celular plasticity

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Baj G., Rauti R., Piva A., Scaini D., Tongiorgi E.

Acta Neurobiologiae Experimentalis

2013

tom 73

nr Suppl.1

The neurotrophin brain-derived neurotrophic factor (BDNF) is involved several aspects of neuronal development and plasticity ranging from cell proliferation and survival to regulation of neuronal shape and synaptic long-term modifications. BDNF occurs in mammals in three different isoforms, a precursor, a truncated form and the mature form. Recent animal and cellular studies showed that mature and pro-BDNF elicit opposite biological effects, leading to the hypothesis that an incorrect balancing of the different isoforms may lead to a different outcome in brain functioning or even cause a pathological effect. We recently found a dysregulation in the levels of the three BDNF forms, including truncated BDNF, in serum from patients affected by schizophrenia, autism or multiple sclerosis. Since the biological role of truncated BDNF is unknown, we investigated its physiological functions using cultured rat hippocampal neurons and found that it has different effects on neuronal survival, dendritic and axonal development and synaptic activity with respect to mature BDNF and pro-BDNF.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Baj G.

1 Piva A.

1 Rauti R.

1 Scaini D.

1 Tongiorgi E.

1 2013

Wyniki wyszukiwania

BDNF proteolytic products: diversity of effects on celular plasticity