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Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress

100%

Sa-Carneiro F., Calhau C., Coelho R., Figueiredo-Braga M.

Acta Neurobiologiae Experimentalis

2020

tom 80

nr 2

Oxidative stress is now believed to play a crucial role for neurodevelopment disorders such as autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). To review the most recent literature regarding the role of oxidative stress for the pathophysiology of ASD and ADHD, we conducted a systematic search of the relevant literature and further discuss the clinical and research implications of this knowledge. A systematic search in PubMed database retrieved 132 articles, of which 33 were included in the review. This review found relevant evidence concerning the role of oxidative status in ASD and ADHD, albeit with some contradictory findings. In order to overcome the incongruities found, more studies are needed in the study of neurodevelopmental disorders, with more thorough study designs and particular attention to the accuracy of the diagnostic tools used for the cases included.

Flavonoid transport across RBE4 cells: a blood-brain barrier model

76%

Faria A., Pestana D., Teixeira D., Azevedo J., De Freitas V., Mateus N., Calhau C.

Cellular and Molecular Biology Letters

2010

tom 15

nr 2

There is a growing interest in dietary therapeutic strategies to combat oxidative stress-induced damage to the Central Nervous System (CNS), which is associated with a number of pathophysiological processes, including Alzheimer’s and Parkinson’s diseases and cerebrovascular diseases. Identifying the mechanisms associated with phenolic neuroprotection has been delayed by the lack of information concerning the ability of these compounds to enter the CNS. The aim of this study was to evaluate the transmembrane transport of flavonoids across RBE-4 cells (an immortalized cell line of rat cerebral capillary endothelial cells) and the effect of ethanol on this transport. The detection and quantification of all of the phenolic compounds in the studied samples (basolateral media) was performed using a HPLC-DAD (Diode Array Detector). All of the tested flavonoids (catechin, quercetin and cyanidin-3-glucoside) passed across the RBE-4 cells in a time-dependent manner. This transport was not influenced by the presence of 0.1% ethanol. In conclusion, the tested flavonoids were capable of crossing this blood-brain barrier model.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Cellular and Molecular Biology Letters

2 Calhau C.

1 Azevedo J.

1 Coelho R.

1 De Freitas V.

1 Faria A.

1 Figueiredo-Braga M.

1 Mateus N.

1 Pestana D.

1 Sa-Carneiro F.

1 Teixeira D.

1 2020

1 2010

Wyniki wyszukiwania

Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress

Flavonoid transport across RBE4 cells: a blood-brain barrier model