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1

Tests of biological activity of metabolites from Penicillium expansum (Link) Thom various isolates

100%
Borecka H., Pytel M., Fenney M.
Acta Agrobotanica
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1984
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tom 37
|
nr 1
2

Cyclodextrin affects the GABAergic currents in cultured rat hippocampal neurons

100%
Mozrzymas J. W., Pytel M., Mercik K.
Acta Neurobiologiae Experimentalis
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2005
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tom 65
|
nr 3
3

Resolving the ionotropic receptor kinetics and modulation in the time scale of synaptic transmission

100%
Pytel M., Mercik K., Mozrzymas J. W.
Cellular and Molecular Biology Letters
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2003
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tom 08
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nr 1
Synaptic transmission plays a crucial role in signal transduction in the adult central nervous system. It is known that synaptic transmission can be modulated by physiological and pathological processes and a number of factors including metal ions, pH, drugs, etc. The patch-clamp technique allows to measure postsynaptic currents, but the mechanism of these currents modulation remains unclear. The estimated value of neurotransmitter transient indicates that this time course is very short and the activation of postsynaptic receptors is extremely non-equilibrient. The ultrafast perfusion system makes it possible to mimic synaptic conditions and, additionally, the agonist concentration can be controlled, which is very important for pharmacokinetic studies. In the present paper, examples of pharmacological modulation of mIPSC kinetics and currents evoked by ultrafast agonist application are presented.
4

Dieta bogata w polifenole roślinne obniża agregację płytek krwi u kobiet z rakiem piersi

88%
Sut A., Pytel M., Zadrozny M., Rozalski M., Golanski J.
Diagnostyka Laboratoryjna
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2018
|
tom 54
|
nr 2
5
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Polyphenol-rich diet is associated with decreased level of inflammatory biomarkers in breast cancer patients

88%
Sut A., Pytel M., Zadrozny M., Golanski J., Rozalski M.
Roczniki Państwowego Zakładu Higieny
|
2019
|
tom 70
|
nr 2
Background. The study investigated the relationship between dietary intake of polyphenols and inflammatory markers: CRP, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), medium platelet volume/lymphocyte ratio (MPVRL), in newly-diagnosed breast cancer patients. Objectives. The aim of this work was to verify whether diet rich in plant polyphenols affects inflammatory markers in breast cancer patients. Materials and methods. 78 patients (55.3±14.5 years) treated surgically for breast cancer were studied. A modified FFQ and authorial worksheet based on the Phenol Explorer database was used to measure the amount of plant polyphenols in a diet. Basing on the median of polyphenols intake (1780 mg/day), the group was divided into two subgroups: low- and high- dietary intake of polyphenols (LDIP and HDIP, respectively). Plasma CRP level was measured and NLR, PLR and MPVLR were calculated using results from peripheral blood morphology. Results. LDIP was associated with significantly higher CRP (elevated in 34.5% LDIP patients vs. 8.3% HDIP, p<0.003), NLR (elevated in 46.2% LDIP patients vs. 25.6% HDIP, p<0.006) and PLR level (elevated in 25.6% LDIP patients vs. 12.8% HDIP, p<0.03). MPVLR was not significantly different between both the subgroups. Conclusion. High dietary intake of polyphenols remarkably reduced process of inflammation in breast cancer patients, which has important clinical implications. The study demonstrated also an usefulness of simple, cheap and commonly available biomarkers for monitoring anti-inflammatory effects of diet.
6

17beta-estradiol alters tonic and phasic GABAergic currents during development in vitro

76%
Wojtowicz T., Pytel M., Mercik K., Sarto-Jackson I., Sieghart W., Ikonomidou C.
Acta Neurobiologiae Experimentalis
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2007
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tom 67
|
nr 3
7

Wplyw plci na zawartosc azotu i aminokwasow w ciele jagniat rasy merynos polski o masie ciala 20 kg

76%
Urbaniak M., Frankiewicz A., Lyczynski A., Pospiech E., Pietrzak M., Pytel M.
Roczniki Akademii Rolniczej w Poznaniu. Zootechnika
|
1999
|
tom 51
215-226
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