The following case study presents a rare advanced penile cancer in a 52 year-old man. The diagnosis of penile cancer is not especially common. Patient with squamous cell carcinoma, which is the most prevalent type of penile cancer, undergo surgical treatment. The first part of the therapy covers a radical penectomy, and the second one − radical pelvic lymphadenectomy. Despite such a drastic surgical procedure, there was a need of further oncological treatment including an adjuvant chemotherapy. Unfortunately, the patient did not continue his treatment. Such advanced stages of penile cancer are very uncommon because of patients being aware of any changes in the genitourinary area. In the early stages of the disease, an isolated resection of penile change or a partial penectomy is usually a sufficient consideration. In such cases, overall survival rates are high. However, more advanced stages typically require a more radical treatment and a systemic approach including chemotherapy and radiotherapy. Then, the results of treatment and prognosis for the patients are not as good as in case of patients with early diagnosed problems.