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1
Content available remote

Therapeutic endoscopy in gastroenterology

100%
Celinski K., Cichoz-Lach H.
Journal of Physiology and Pharmacology. Supplement
|
2007
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tom 58
|
nr 3
33-41
2
Content available remote

Modern methods of endoscopic diagnosis of gastrointestinal tract

100%
Cichoz-Lach H., Celinski K.
Journal of Physiology and Pharmacology. Supplement
|
2007
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tom 58
|
nr 3
21-31
3

Hospitalization frequency caused by inflammatory bowel disease in rural and urban inhabitants

81%
Cichoz-Lach H., Celinski K., Slomka M.
Polish Journal of Environmental Studies
|
2010
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tom 19
|
nr 5
The purpose of our study was to analyze hospitalizations for inflammatory bowel disease noted in the Department of Gastroenterology, Medical University of Lublin. Cases of patients hospitalized in the Department of Gastroenterology, Medical University of Lublin in 1997-2007 were retrospectively analyzed. The material studied included patients’ case histories and medical records that were used to select such patients whose hospitalizations were caused by ulcerative colitis and Crohn’s disease. Analysis distinguished two groups: rural and urban inhabitants. In 1997-2007 there were 1,825 hospitalizations for the inflammatory bowel disease noted at our clinic, which was 12.15% of all hospitalizations: 8.54% patients with ulcerative colitis and 3.61% with Crohn’s disease. Among them, 30.47% were rural inhabitants while 69.53% of patients lived in towns. The observation data demonstrated that there has been a significant increase of patients with inflammatory bowel disease in the last decade, and the patients originating in urban areas were more frequent than those from rural regions. This may be related to environmental differences between these two population groups.
4
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Content available

Ganglioneuromatous polyposis associated with type 2 B multiple endocrine neoplasia (MEN 2B) - case report

81%
Rycyk-Bojarzynska A., Kasztelan-Szczerbinska B., Cichoz-Lach H., Jargielo A.
Annals of Agricultural and Environmental Medicine
|
2024
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tom 31
|
nr 2
5
Content available remote

Pathophysiology of portal hypertension

80%
Cichoz-Lach H., Celinski K., Slomka M., Kasztelan-Szczerbinska B.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 2
In last years significant progress in recognizing mechanisms of portal hypertension pathophysiology was done. However, some unclear topics in this disease still exist. Portal hypertension is primarily caused by the increase in resistance to portal outflow and secondly by an increase in splanchnic blood flow. Portal hypertension is associated with changes in the intrahepatic, systemic, and portosystemic collateral circulation. Alterations in vasoreactivity (vasodilation and vasoconstriction) play a central role in the pathophysiology of portal hypertension by contributing to increased intrahepatic resistance, hyperdynamic circulation, and expansion of the collateral circulation. Among vasoactive substances which are activated in portal hypertension nitric oxide (NO) is considered as the most important vasodilator. Endothelin-1 and cyclooxygenase-derived prostaglandins are the main vasoconstrictor factors. The imbalance between the hyperresponsiveness and overproduction of vasoconstrictors and the hyporesponsiveness and impaired production of vasodilators are the mechanisms responsible of the increased vascular tone in the sinusoidal area of the liver. New concepts in the pathophysiology of portal hypertension find the significant role of hepatic stellate cells activated by endothelial factors which cause vascular remodeling as an adaptive response of the portal vessels wall. The most frequent causes of portal hypertension include portal vein thrombosis, storage diseases of the liver, hepatic cirrhosis (independent of etiology), hepatic veins thrombosis and schistosomiasis. Understanding the pathophysiology of portal hypertension could be of great utility in preventing and curing the complications of portal hypertension, such as esophageal varices, hepatic encephalopathy, ascites.
6
Content available remote

The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis

71%
Cichoz-Lach H., Celinski K., Konturek P. C., Konturek S. J., Slomka M.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 5
7
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Content available

Gullo’s syndrome – case report

71%
Rycyk A., Furtak P., Madro A., Kasztelan-Szczerbinska B., Cichoz-Lach H.
Journal of Pre-Clinical and Clinical Research
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2020
|
tom 14
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nr 4
8
Content available remote

Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans

61%
Celinski K., Konturek P. C., Konturek S. J., Slomka M., Cichoz-Lach H., Brzozowski T., Bielanski W.
Journal of Physiology and Pharmacology
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2011
|
tom 62
|
nr 5
9
Content available remote

Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease – 14 months follow up

61%
Celinski K., Konturek P. C., Slomka M., Cichoz-Lach H., Brzozowski T., Konturek S. J., Korolczuk A.
Journal of Physiology and Pharmacology
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2014
|
tom 65
|
nr 1
10
Content available remote

Non-variceal upper gastrointestinal bleeding-guidelines on management

61%
Celinski K., Cichoz-Lach H., Madro A., Slomka M., Kasztelan-Szczerbinska B., Dworzanski T.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 2
In gastroenterology non-variceal upper gastrointestinal bleeding is health hazard. Frequency of occurrence accounts for 40-150 cases per 100000 inhabitants with death rate of 7-14%. Researches which goal is to improve treatment effectiveness as well as to establish standardized procedures for managing patients with symptoms of non-variceal upper gastrointestinal bleeding; have been conducted since many years. At the moment of admission, designed standards enable appropriate elaboration of patients’ health state, referral to the right clinic and implementation of the most accurate treatment methods. Increase of suppression of primary bleeding as well as prevention of recurrence is associated with dynamic development of endoscopic treatment methods as well as with optimization of pharmacological treatment. In significant percentage, efficiency of non – variceal bleedings treatment depends on clinic’s character (availability of equipment, experience of personnel) and on cooperation between several specialists (including gastroenterologist, surgeon, anesthetist, operative radiologist). Aim of the work is to present the latest evaluation of the mentioned subject, based on accessible literature. This work includes the basic principles for determination of bleeding intensity and risk of its recurrence as well as directions referring to fluids resuscitation and to monitoring of patients. Information on currently applied endoscopic methods for inhibition of non variceal upper gastrointestinal bleeding (injection, mechanical and thermo-coagulation techniques), comparison of their efficiency and possibility of application is provided in the work. The paper work also presents the newest directives for pharmacological treatment and guidelines for possible surgical treatment.
11
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Content available

The effects of environmental factors on the prevalence of Helicobacter pylori infection in inhabitants of Lublin Province

61%
Celinski K., Kurzeja-Miroslaw A., Slomka M., Cichoz-Lach H., Madro A., Kasztelan-Szczerbinska B.
Annals of Agricultural and Environmental Medicine
|
2006
|
tom 13
|
nr 2
The aim of the study was to analyse the prevalence of H. pylori infection in adult inhabitants of Lublin Province. The effects of living conditions and lifestyle on the infection frequency were evaluated. The study included 585 adults randomly chosen for the epidemiological analysis of H. pylori infection in the Lublin region within the project commissioned by the Ministry of Health (PCZ 08-09) and State Committee for Scientific Research (C007/P05/2000). The study was based on a personal questionnaire and determinations of anti/Hp antibodies in IgG class using the ELISA method. High titres of anti/Hp antibodies (>24 IU/ml) were demonstrated in 78.5% of the subjects. In Lublin Province the infected individuals constitute 72% of inhabitants, in the big towns - 74% and in small towns - 95%. According to the place of birth: among those born in the country 87% are infected, compared to 78.4% in the small towns and 64% in the big towns, respectively. Positive test results were observed in 79% of farmers, 78% of manual workers and 75% of mental workers. The percentage of the affected neglecting basic hygienic rules exceeded 90%. With increased frequency of hygienic measures the number of the H. pylori infected individuals decreased to 65%. The prevalence of H. pylori infection among the inhabitants of the Lublin region is lower than that found in town inhabitants. Lublin Province shows the lowest level of H. pylori infection in Poland. The H. pylori infection is strongly affected by the lack of basic rules of personal hygiene and improper diet.
12
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Content available

The effect of caerulein-induced acute pancreatitis on the levels of serotonin [5-HT] and 5-hydroxyindoleacetic acid [5-HIAA] in various rat tissues

61%
Celinski K., Kleinrok Z., Pokora J., Czechowska G., Skrzydlo-Radomanska B., Cichoz-Lach H.
Journal of Physiology and Pharmacology
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1995
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tom 46
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nr 2
13
Content available remote

Influence of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist, rosiglitazone and antagonist , biphenol-A-diglicydyl ether (BADGE) on the course of inflammation in the experimental model of colitis in rats

51%
Dworzanski T., Celinski K., Karolczuk A., Slomka M., Radej S., Czechowska G., Madro A., Cichoz-Lach H.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 6
14
Content available remote

Melatonin and its precursors L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans

51%
Konturek P. C., Celinski K., Slomka M., Cichoz-Lach H., Burnat G., Naegel A., Bielanski W., Konturek J. W., Konturek S. J.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 2
Melatonin (MT) and its precursor L-tryptophan (Trp) are implicated in the protection of gastric mucosa against noxious agents. However, the role of MT and Trp on the gastric mucosal injury induced by aspirin (ASA) in human has not been investigated. Studies in animals showed that both MT and Trp given intragastrically prevents the formation of gastric mucosal lesions induced by ASA. The aim of the present study was to determine the influence of MT and Trp given orally to healthy humans on gastric mucosal lesions induced by ASA. The present study included 21 healthy, Hp-negative male volunteers with intact gastro-duodenal mucosa aging 20-50 yr. They were divided in 3 groups; group1: 7 volunteers receiving daily 2 x 1g ASA (Polfa, Rzeszow) during 11 days; group 2: 7 healthy volunteers receiving 2x1g ASA and MT (Lekam, Zakroczyn) (5 mg 30 min prior to ASA) during 11 days and group 3: 7 healthy volunteers receiving 2x1g ASA and Trp (Ardeytropin, Germany) (0.5 g 30 min prior to ASA) during 11 days. Mucosal damage was evaluated at 3rd, 7th and 11th days of ASA administration by endoscopy using Lanza score. Plasma melatonin was measured using RIA and gastric mucosal generation of PGE2 was assessed also by RIA. ASA caused marked mucosal injury at all days of its administration except day 11th when only moderate lesions were evident. Pre-treatment with MT or Trp alone was accompanied by a significant decrease in gastric mucosal lesion score. Gastric mucosal generation of PGE2 was suppressed by about 90% in subjects treated with ASA without or with MT or Trp. We concluded that: MT and its precursor Trp significantly attenuate gastric mucosal lesions induced by aspirin. The action of Trp may be be mediated by MT produced in gastrointestinal tract from Trp. The gastroprotective action of MT and Trp is independent on gastric mucosal PGE2 generation.
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