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The aim of the study was to investigate the profile of Epstein-Barr virus (EBV) antibodies and to compare this profile with the detectability of EBV DNA and compare this profile in healthy people with the profile in patients with blood disorders. The profile of antibodies was examined in serum from the following groups: 40 patients with blood disorders, but without EBV DNA in their lymphocytes, 44 patients with blood disorders and EBV DNA in lymphocytes, and 46 healthy people. EBV antibodies were detected by using ELISA commercial kits. The obtained results were analysed by Fisher's exact test. No significant differences in antibody profiles were found between EBV DNA-positive and EBV DNA-negative sera. Between patients and the control group, considerable differences were observed in reactivation and in past infection, and a significant difference was observed in chronic infection. These analyses suggest that EBV reactivation or chronic infection can be related with blood disorders and have an influence on the course of blood disorders.
The aim of this study was to check the presence of DNA of five human herpesviruses in lymphocytes isolated from peripheral blood of people with lymphoproliferative diseases and to investigate the relationship between these disorders and the presence of the viruses. A total of 113 blood specimens from patients with different blood disorders and 96 specimens from healthy people (control group) were obtained. Among 113 specimens from patients with blood disorders, DNA of EBV in 39.8%, CMV in 30.1%, HHV6 in 8.0%, HHV7 in 20.4%, and HHV8 in 9.7% of the people was detected. Among 96 specimens from healthy people, DNA of EBV was detected in 9.3%, CMV in 27.1%, HHV6 in 4.2%, HHV7 in 13.5%, and HHV8 in 4.2%. It was found that the differences in presence and number of viruses between groups were very significant. Significantly, a larger detection of DNA of EBV in blood disorder group was observed. These results suggest the participation of EBV in blood disorders.
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