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1

Zastosowanie zmodyfikowanych oligonukleotydów w badaniach nad mechanizmem działania endonukleazy Eco RI

100%
Koziolkiewicz M.
Postępy Biochemii
|
1991
|
tom 37
|
nr 2
2

Oddziaływanie restrykcyjnej endonukleazy Eco RI i DNA

100%
Koziolkiewicz M.
Postępy Biochemii
|
1991
|
tom 37
|
nr 1
3

Stabilnosc oligonukleotydow antysensowych - mozliwosci ich degradacji enzymatycznej

100%
Koziolkiewicz M.
Biotechnologia
|
1994
|
nr 4
50-54
4

Omowienie Sekcji II Krajowego Kongresu Biotechnologii. Sekcja A - Biotechnologia dla ochrony zdrowia

100%
Koziolkiewicz M.
Biotechnologia
|
2004
|
nr 3
17-19
5

Koncepcje nutrigenomiki

100%
Koziolkiewicz M.
Biotechnologia
|
2009
|
nr 4
9-34
6

Strategia antysensownych oligonukleotydow - nowe trendy.

100%
Koziolkiewicz M.
Postępy Biochemii
|
1998
|
tom 44
|
nr 2
125-135
7

Oligonukleotydy o wlasnosciach aptametrycznych.

63%
Krakowiak A., Koziolkiewicz M.
Postępy Biochemii
|
1998
|
tom 44
|
nr 4
306-317
8

Albuminy 2S - roslinne bialka zapasowe o wlasciwosciach alergennych

63%
Czarnecka J., Koziolkiewicz M.
Biotechnologia
|
2007
|
nr 2
114-127
9

Oligonukleotydy: czy tylko fragmenty kwasow nukleinowych?

63%
Stec W. J., Koziolkiewicz M.
Kosmos
|
2000
|
tom 49
|
nr 3
489-501
10

Budowa, mechanizm dzialania i funkcje biologiczne enzymow z rodziny pirofosfataz-fosfodiesteraz ektonukleotydow [E-NPP]

51%
Wojcik M., Szmalenberg B., Koziolkiewicz M.
Postępy Biochemii
|
2003
|
tom 49
|
nr 3
202-212
11

In vitro gastrointestinal digestion study of red cabbage phenolic compounds

51%
Redzynia M., Podsedek A., Koziolkiewicz M.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
12

Degradation of extracellular nucleotides and their analogs in HeLa and HUVEC cell cultures

51%
Gendaszewska-Darmach E., Maszewska M., Zaklos M., Koziolkiewicz M.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 4
The use of nucleotides and their analogs in the pharmacological studies of nucleo­tide receptors (P2 class) should be preceded by detailed studies on their degradation connected with ecto-enzymes of a given cell type. In the present studies we have ana­lyzed stability of some phosphorothioate and phosphonate analogs of ATP and ADP in the HeLa epitheloid carcinoma and endothelial HUVEC cells cultures. Our studies have revealed that ecto-nucleotide pyrophosphatase (E-NPP) is one of the main en­zymes involved in the extracellular degradation of ATP and other nucleotides in the HeLa cells. On the other hand, the ecto-ATPDase is responsible for the hydrolysis of extracellular nucleotides in human endothelial cell cultures, while the E-NPP-like en­zymes of the HUVEC cells are not essential to this degradation. The concerted action of the aforementioned ecto-enzymes and nucleotide pyrophosphatase, 5 -nucleo- tidase and adenosine deaminase present in fetal bovine serum (FBS) supplied to the culture medium, results in partial or complete degradation of the phosphorothioate (ATPγS) and phosphonate analogs of adenosine nucleotides (α,β-methylene-ATP and β,γ-methylene-ATP) in the cell cultures. Only ADPβS appears to be resistant to these enzymes. The influence of some nucleotides and their analogs on the proliferation of the HeLa cells in presence or absence of FBS is also discussed.
13

Effect of isothiocyanates and polyphenolic extracts of Cruciferous vegetables on the induction of apoptosis in HL 60 cells

45%
Zaklos M., Podsedek A., Sosnowska D., Majda T., Koziolkiewicz M.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
14

Flavanols from Japanese quince (Chaenomeles japonica) fruit suppress expression of cyclooxygenase-2, metalloproteinase-9, and nuclear factor-kappaB in human colon cancer cells

39%
Owczarek K., Hrabec E., Fichna J., Sosnowska D., Koziolkiewicz M., Szymanski J., Lewandowska U.
Acta Biochimica Polonica
|
2017
|
tom 64
|
nr 3
15

Molecular basis of cellulose biosynthesis disappearance in submerged culture of Acetobacter xylinum

39%
Krystynowicz A., Koziolkiewicz M., Wiktorowska-Jezierska A., Bielecki S., Klemenska E., Masny A., Plucienniczak A.
Acta Biochimica Polonica
|
2005
|
tom 52
|
nr 3
Acetobacter xylinum strains are known as very efficient producers of bacterial cellulose which, due to its unique properties, has great application potential. One of the most important problems faced during cellulose synthesis by these bacteria is generation of cellulose non-producing cells, which can appear under submerged culture conditions. The reasons of this remain unknow. These studies have been undertaken to compare at the molecular level wild-type, cellulose producing (Cel+) A. xylinum strains with Cel- forms of cellulose-negative phenotype. Comparison of protein profiles of both forms of A. xylinum by 2D electrophoresis allowed for the isolation of proteins which were produced exclusively by either Cel+ or Cel- cells. Sequences of peptides derived from these proteins were aligned with those of proteins deposited in databases. This analysis revealed that Cel- cells lacked two enzymes: phosphoglucomutase and glucose-1-phosphate uridylyltransferase, which generates UDP-glucose being the substrate for cellulose synthase. DNA was analyzed by ligation-mediated PCR carried out at low denaturation temperature (PCR-MP). Two DNA fragments of different thermal stability (218 and 217 bp) were obtained from the DNA of Cel+ and Cel- forms, respectively. The only difference between these Cel- and Cel+ DNA fragments is deletion of one T residue. Alignment of those two sequences with those deposited in the GenBank database revealed that similar fragments are present in the genomes of some bacterial cellulose producers and are located downstream from open reading frames (ORF) encoding phosphoglucomutase. The meaning of this observation is discussed.
16

Anticancer activites of polyphenolrich plant extracts

33%
Gorlach S., Kustra D., Szewczyk K., Strek M., Hrabec E., Podsedek A., Sosnowska D., Koziolkiewicz M.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
17
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Content available

Influence of polyphenol extract from evening primrose (Oenothera Paradoxa) seeds on proliferation of Caco-2 cells and on expression, synthesis and activity of matrix metalloproteinases and their inhibitors

33%
Szewczyk K., Lewandowska U., Owczarek K., Sosnowska D., Gorlach S., Koziolkiewicz M., Hrabec Z., Hrabec E.
Polish Journal of Food and Nutrition Sciences
|
2014
|
tom 64
|
nr 3
18
Content available remote

Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells

33%
Chojnacka K., Owczarek K., Caban M., Sosnowska D., Polka D., Koziolkiewicz M., Fichna J., Lewandowska U.
Journal of Physiology and Pharmacology
|
2020
|
tom 71
|
nr 6
19

Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group

33%
Misiura K., Wojcik M., Krakowiak A., Koziolkiewicz M., Pawlowska Z., Pluskota E., Cierniewski C. S., Stec W. J.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 1
Dimethoxytritylphosphono-oligonucleotide conjugates have been prepared. They are totally resistant to nucleases present in human serum and do not affect cleavage of a complementary oligoribonucleotide by RNase H. Conjugates possessing a phosphate backbone gave better antisense inhibition of expression of plasminogen activator inhibitor type-1 within endothelial cells as compared with unconjugated oligonucleotides.
20

Antisense oligonucleotides to PAI-1 mRNA as potential agents for therapeutic intervention in cardiovascular diseases

33%
Cierniewski C. S., Pawlowska Z., Pluskota E., Stasiak M., Kobylanska A., Misiura K., Maciaszek A., Koziolkiewicz M., Stec W. J.
Biotechnologia
|
1996
|
nr 4
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