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1

Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble ABeta25-35 in the Alzheimer's disease model rat brain: effect of memantine

100%
Arif M., Kato T.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 4
703-714
Peptidylarginine deiminases (PADs) convert the arginine residues in proteins into citrulline residues in a Ca2+-dependent manner. We previously showed that a bilateral injection of ibotenic acid into the rat nucleus basalis magnocellularis elevated the PAD2 activity in the hippocampus and striatum. In this study, we examined whether repeated intracerebroventricular infusions of soluble Aβ25–35 would affect the PAD2 expression in any regions of the rat brain. We also assessed the protective effect of memantine on Aβ-induced PAD2 alterations. The infusion of Aβ25–35 increased the activity and protein level of PAD2 in the hippocampus, and co-treatment with memantine suppressed these changes. An immunohistochemical analysis showed that an increased level of PAD2 was coincident with GFAP-positive astrocytes and CD11b-positive microglia. In addition, immunofluoresecence staining revealed that citrullinepostive immunoreactivity coincided with the occurrence of GFAP-positive astrocytes. Co-treatment with memantine reversed the activation of the astrocytes and microglia, thus attenuating the PAD2 increment. These biochemical and immunohistochemical results suggest that PAD2 might play an important role in the pathology of early Alzheimer’s disease, and may correlate with the changes in glial cells that are recovered by memantine treatment.
2

Impact of increasing crude glycerine levels in diet on growth, carcass traits, body measurements and blood cholesterol in growing Japanese quails

81%
Arif M., Hayat Z., Sohail S., Abd El-Hack M. E.
Journal of Animal and Feed Sciences
|
2017
|
tom 26
|
nr 1
The aim of the study was to evaluate the effect of dietary inclusion of crude glycerine on growth performance, carcass traits, body measurements and blood cholesterol level of growing Japanese quails. In total 375 one-dayold Japanese quails were randomly divided into five equal groups under complete randomized design. Experimental groups were as follows: T1: basal diet (without glycerine addition), T2: basal diet + 2.5% glycerine, T3: basal diet + 5% glycerine, T4: basal diet + 7.5% glycerine, and T5: basal diet + 10% glycerine. Each treatment was replicated 5 times, 15 birds in each replicate. It was observed that glycerine supplementation did not significantly (P > 0.05) affect the feed intake and body weight of birds. Dietary inclusion of glycerine at a dose of 2.5 and 5% had positive impact on feed conversion ratio (quadratic, P = 0.021) in comparison to control group. Glycerine inclusion in the diet did not affect total blood cholesterol level. Furthermore, neither carcass traits nor body measurements were statistically influenced by the different inclusion levels of glycerine. So, it could be stated that in order to obtain positive effects on quail growth performance, crude glycerine could be used in diets as a source of energy at levels of 2.5 and 5%.
3
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Dissecting the action of H2O2 after its metabolic formation in chloroplasts

71%
Jaspert N., Balazadeh S., Arif M., Muller-Rober B., Maurino V.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
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tom 94
|
nr 2
4

Effect of gradual substitution of soyabean meal by Nigella sativa meal on growth performance, carcass traits and blood lipid profile of growing Japanese quail

61%
Abd El-Hack M. E., Alagawany M., Saeed M., Arif M., Arain M. A., Bhutto Z. A., Fazlani S. A.
Journal of Animal and Feed Sciences
|
2016
|
tom 25
|
nr 3
The aim of the study was to evaluate the effect of different inclusion levels of meal (NSM) on growth performance, carcass yield and blood lipid profile of 300 unsexed one-week old Japanese quails. The experimental diets contained four levels of NSM replacing 0 (control), 20, 30 and 40% of soyabean meal (SBM) in growing Japanese quail diets. Live body weight was linearly ( = 0.017) and quadratically ( = 0.024) increased at week 3 of age and only quadratically ( > 0.001) at week 6 of age due to 30% SBM substitution. Birds fed diets with 20 and 30% SBM replaced by NSM consumed more feed in comparison with other animals during 3-6 and 1-6 week of age. The substitution of 20% SBM for the same percent of NSM resulted in a significant ( < 0.001) linear increase in both dressing and carcass percentages in comparison with the control and other treatment groups, giblets yield was also significantly (linearly = 0.011 and quadratically = 0.021) affected. A gradual reduction in serum total lipids, total cholesterol and HDL-cholesterol was observed along with the increasing level of NSM in the diet, except HDL which was elevated when 40% of SBM was replaced. It could be concluded that NSM could partially replace SBM up to 30% in growing Japanese quail diets without any harmful hazards regarding performance, feed utilization and carcass traits. Moreover, the blood lipid parameters are decreased with increasing NSM content in the diet.
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Foliar application of nutrient for augmentation of rhizospheric heavy metal stress - growth and productivity of canola (Brassica napus L.) measured with indices

61%
Ahmad A., Saima S., Parveen M., Ali E., Arif M., Yasin G., Akmal F.
Journal of Elementology
|
2023
|
tom 28
|
nr 1
6

Dengue outbreaks in Khyber Pakhtunkhwa (KPK), Pakistan in 2017: an integrated disease surveillance and response system (IDSRS)-based report

51%
Abdullah, Alf S., Salman M., Din M., Khan K., Ahmad M., Khan F. H., Arif M.
Polish Journal of Microbiology
|
2019
|
tom 68
|
nr 1
The current study is a retrospective epidemic report regarding dengue fever (DF) virus infection cases (2017) from fifteen districts of KPK, Pakistan. Medical records of 120948 patients were reviewed retrospectively for demographic, clinical and laboratory data. The presence of dengue infection was confirmed by NS1-ELISA and RT-PCR, respectively. The total positive cases (of suspected DF samples) were 24938 (20.6%), whereas seventy cases (0.28%) had a fatal outcome. Mean age ±SD of the dengue patients was 26±19.8 years, while; the most affected age group was from 16 to 30 years (Chi-square: 12820.125, p:0.00). The infected males were 65.3%, and that of the female was 34.7%. All the dengue-infected patients were observed with symptoms of severe fever (100%), body aches (95%), gums and nose bleeding (5%), skin rashes (30%), vomiting (70%). The highest infection rate was found in district Peshawar and that of the lowest was in Bannu, Hungu and Luki Marwat. A high rate of dengue infection was found in post-monsoon months i.e. October (41%) and September (32%) of the year. The results proved that if the dengue outbreaks reveal further in KPK, it could alarmingly increase the mortality rate. Therefore, the Department of Public Health in KPK, Pakistan may take proper measures to avoid and control dengue epidemics in the future.
7

Herbal medicine additives as powerful agents to control and prevent avian influenza virus in poultry - a review

51%
Gado A. R., Ellakany H. F., Elbestawy A. R., El-Hack M. E., Khafaga A. F., Taha A. E., Arif M., Mahgoub S. A.
Annals of Animal Science
|
2019
|
tom 19
|
nr 4
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Peach antioxidant and phenolic activities influenced by the application of 1-methylcyclopropene (1-MCP) at post-harvest

51%
Shah S. T., Sajid M., Khan N. U., Rab A., Amin N. U., Arif M., Haleema B., Saeed S.
Acta Scientiarum Polonorum. Hortorum Cultus
|
2019
|
tom 18
|
nr 2
Early maturing peach (Prunus persica) cultivars can fetch good market value but face a lot of post-harvest problems that lead to the post-harvest losses. The 1-methylcyclopropene (1-MCP) can provide new insights into plant ethylene responses and extend the shelf life and quality of fruits. Therefore, fruits of peach cultivar ‘Early Grand’ were dipped in various concentrations of 1-MCP (0, 0.3, 0.6 and 0.9 µg l–1), stored for 40 days at 8 ±2°C with 50% relative humidity and analyzed the fruits for physicochemical attributes at 10 days interval. The highest concentration of 1-MCP at 0.9 µg l–1 significantly improved the activity of antioxidants, catalase, free radical scavenging assay and total phenols. However, the peach fruits treated with 1MCP at 0.6 µgL–1 was effective in retaining the ascorbic acid, lowering the weight loss and fruit decay. Therefore, peach fruits can be treated with 1-MCP (0.6 µg l–1) solution for prolonging its shelf life up to 40 days under low temperature.
9

Impacts of distiller’s dried grains with solubles as replacement of soybean meal plus vitamin E supplementation on production, egg quality and blood chemistry of laying hens

42%
Saeed M., Abd E-Hack M. E., Arif M., El-Hindawy M. M., Attia A. I., Mahrose K. M., Bashir I., Siyal F. A., Arain M. A., Fazlani S. A., Hayat K., Sun C., Noreldin A. E.
Annals of Animal Science
|
2017
|
tom 17
|
nr 3
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