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In vitro babies – medical and legal aspects: a European and North American perspective

100%

Gadzinowski J., Merritt T. A., Jopek A., Kochanski A., Lavery A., Merritt T.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2012

tom 93

nr 1

Umbilical cord serum magnesium level and neonatal outcome in group of neonates at 30-34 gestational age

84%

Gulczynska E., Zylinska L., Kesiak M., Grodzicka A., Zjawiona A., Cyranowicz B., Krekora M., Talar T., Gadzinowski J.

Journal of Elementology

2007

tom 12

nr 1

Aim of study. To find correlation between the umbilical serum cord magnesium concentration in a group of newborns without antenatal exposition to magnesium sulphate and the neonatal outcome as well as to compare the neonatal outcome of babies with maternal magnesium sulphate treatment. Results. In a group of 82 newborns (31-34 GA; birth body weight <1500 g) the umbilical cord serum magnesium concentrations was assayed. Three subgroups of neonates were set apart: first group (N) with a normal magnesium level (n=28), the second group (n=19) with magnesium concentration <0.75 mmol/dl (D), and the third group (Mg) consisting of 35 newborn antenatally exposed to magnesium sulphate. These groups were similar (no statistical significances) in terms of birth body weight, gestational age, Apgar score and umbilical blood pH. Gradual decrease in magnesium concentration in relation to increase of gestational age was observed. In groups: D, N, Mg, gradual reduction of hospitalization time (p<0.05), risk of death, time of respiratory support, time of oxygen therapy, rate of bronchopulmonary dysplasia, periventricular leucomalation (p<0.05) were observed respectively. Likewise, a rate of serious neurological complication (IVH/ PVL) in group D was higher in comparison to groups N and Mg (although without statistical sig-nificances). Conclusion. Our results confirm that umbilical cord magnesium concentration in VLBW neonates have an influence on neonatal outcome. Although it is premature to recommend ordering maternal magnesium sulphate treatment to improve neonatal outcome, in our opinion the data presented here should at least induce magnesium concentration monitoring in pregnant women and magnesium deficiency correction.

Polish Registry of Congenital Malformations - aims and organization of the registry monitoring 300 000 births a year

52%

Latos-Bielenska A., Materna-Kiryluk A., Balcar-Boron A., Borszewska-Kornacka M., Breborowicz G., Czerwionka-Szaflarska M., Dobrzanska A., Gadzinowski J., Gajewska E., Godula-Stuglik U., Helwich E., Krawczynski M., Limon J., Mazurczak T., Mejnartowicz J., Sawulicka-Oleszczuk H., Rusin J., Stanczyk J., Szczapa J., Szwalkiewicz-Warowicka E., Swietlinski J., Szymanski W., Walczak M.

Journal of Applied Genetics

2005

tom 46

nr 4

341-348

In 1997, the Polish Registry of Congenital Malformations (PRCM) was established, to fulfil epidemiological, prophylactic, socioeconomic and scientific functions. The PRCM is a population-based registry monitoring currently about 300 000 births a year in 13 provinces. Such a large area and population require a special organizational structure of the Registry. The PRCM Central Working Group and the computer database are located in the Department of Medical Genetics, University of Medical Sciences, Poznań. Here the data are collected, validated, encoded according to the ICD-10, and analysed. Provincial Working Groups are responsible for supervision of data collection in the given province. The PRCM staff has grown from about 250 members in 1997 to more than 400 members today. The PRCM collects information on structural defects diagnosed before the end of the second year of life. Minor anomalies are excluded from the registry. The main source of information is a registration form filled up by the physician diagnosing the anomaly. Since 2004 also electronic reporting has been possible. On 28 September 2005 there were 54 020 entries in the database concerning 33 729 children with at least one congenital malformation and 1261 control entries concerning children without malformations. The PRCM is also an important source of identification of families at genetic risk. Education of physicians and the community in the field of genetic counselling is also an important aim of the PRCM. Since 2001, the PRCM has been a member of the Eurocat. Detailed information on PRCM organization, electronic reporting, and results are available at the PRCM website (www.rejestrwad.pl).

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Wyniki wyszukiwania

In vitro babies – medical and legal aspects: a European and North American perspective

Umbilical cord serum magnesium level and neonatal outcome in group of neonates at 30-34 gestational age

Polish Registry of Congenital Malformations - aims and organization of the registry monitoring 300 000 births a year