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Rezonans magnetyczny i spektroskopowa ocena metabolitow tkanki mozgowej w przebiegu kryptokokozy OUN

100%
Wiercinska-Drapalo A., Tarasow E.
Wiadomości Parazytologiczne
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2001
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tom 47
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nr 3
535-541
Cryptococcus neoformans is the causative agent of cryptococcosis and cryptococcal meningitis, which are serious pathological conditions affecting up to 10% of patients with AIDS. In this paper we present results magnetic resonance imaging and spectroscopic metabolites (1H MR) in brain cryptococcosis. In 1HMR spectroscopy we tind decreased metabolic ratios to nonsaturated water (H2O) signal N-acetylaspartate (NA/H20, creatine (Cr/H20), choline (Cho/H20). We show increased mioinositol to H2O ratio. Spectroscopy results suggest about massive neuronal injury and accompanying gliosis in brain cryptococcosis.
2

Retinol binding protein-4 as a serum biomarker of intrahepatic lipid content in obese children - preliminary report

71%
Romanowska A., Lebensztejn D., Skiba E., Tarasow E., Kaczmarski M.
Acta Biochimica Polonica
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2011
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tom 58
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nr 1
Objectives: Obesity, insulin resistance and dyslipidemia are the most significant risk factors of non-alcoholic fatty liver disease (NAFLD) but the role of adipokines in the pathogenesis of this disease is not clear. Assessment of retinol binding protein (RBP-4) seems to be promising because data from animal and human studies suggest its role in the patomechanism of insulin resistance. Therefore, the aim of the study was to evaluate the serum levels of RBP-4 in children with NAFLD. Methods: Fasting serum level of RBP-4 was determined in 42 obese children with suspected liver disease and 20 lean controls. The degree of liver steatosis was graded in ultrasound according to Saverymuttu. The intrahepatic lipid content was assessed noninvasively in a semiquantitative fashion using 1HMR spectroscopy (1.5-T scanner with PRESS sequence). Results: Fatty liver was confirmed in 30 children by ultrasonography (16 of them had also increased alanine transaminase (ALT) activity). Serum concentrations of RBP-4 were significantly higher in obese children with NAFLD compared to controls. Significant correlations were found between RBP-4 level and ultrasonographic grade of liver steatosis, intrahepatic lipid content (1HMRS) and triglycerides level, while the serum level of RBP-4 was not significantly higher in children with advanced liver steatosis (grade 2-3, n = 11) compared to patients with mild steatosis (grade 1, n = 19). The ability of RBP-4 to differentiate children with advanced liver steatosis from those with mild steatosis was not significant. Conclusion: RBP-4 can be considered as a convenient serum marker of intrahepatic lipid content in obese children.
3
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Przydatnosc nowoczesnych technik obrazowania w diagnostyce bablowicy watroby

71%
Grzeszczuk A., Tarasow E., Kubas B., Walecki J., Prokopowicz D.
Wiadomości Parazytologiczne
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2001
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tom 47
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nr 4
565-572
Cystic and alveolar echinococcosis, parasitic diseases, caused in humans by the larval stage of tapeworm Echinococcus granulosus and E. multilocularis are rare diseases in Poland. We have diagnosed 71 patients with cystic echinococcosis and 10 patients with alveolar echinococcosis during last 12 years. Echinococcosis still create significant diagnostic difficulties, particularly alveolar one. Progress and actually available radiological imaging techniques, which can be applied in the cystic and alveolar echinococcosis diagnostics, are presented. Ultrasound appearance, CT, MRI images are described. Own experience with Proton Magnetic Resonans Spectroscopy in two patients with recurrent alveolar echinococcosis are presented.
4

Estimation of gamma-glutamyl transferase as a suitable simple biomarker of the cardiovascular risk in children with non-alcoholic fatty liver disease

61%
Bobrus-Chociej A., Daniluk U., Flisiak-Jackiewicz M., Wojtkowska M., Klusek-Oksiuta M., Tarasow E., Lebensztejn D.
Acta Biochimica Polonica
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2018
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tom 65
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nr 4
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