Wyniki wyszukiwania

1

Blood pressure-independent hypotrophy of the heart, kidneys and conduit arteries after 7-nitroindazole administration to Wistar rats from the prenatal period to adulthood

100%

Kristek F., Malekova M., Ondrias K., Cacanyiova S.

Journal of Physiology and Pharmacology

|

2013

|

tom 64

|

nr 1

2

Effect of chronic neuronal nitric oxide-synthase inhibition on arterial function and structure in spontaneously hypertensive rats

100%

Cacanyiova S., Kristek F., Malekova M., Ondrias K.

Journal of Physiology and Pharmacology

|

2012

|

tom 63

|

nr 1

3

The adaptive role of nitric oxide and hydrogen sulphide in vasoactive responses of thoracic aorta is triggered already in young spontaneously hypertensive rats

76%

Cacanyiova S., Berenyiova A., Kristek F., Drobna M., Ondrias K., Grman M.

Journal of Physiology and Pharmacology

|

2016

|

tom 67

|

nr 4

4

Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats

76%

Drapala A., Koszelewski D., Tomasova L., Ostaszewski R., Grman M., Ondrias K., Ufnal M.

Acta Biochimica Polonica

|

2017

|

tom 64

|

nr 3

5

Stilbene derivatives inhibit the activity of the inner mitochondrial membrane chloride channels

64%

Koszela-Piotrowska I., Choma K., Bednarczyk P., Dolowy K., Szewczyk A., Kunz W. S., Malekova L., Kominkova V., Ondrias K.

Cellular and Molecular Biology Letters

|

2007

|

tom 12

|

nr 4

493-508

Ion channels selective for chloride ions are present in all biological membranes, where they regulate the cell volume or membrane potential. Various chloride channels from mitochondrial membranes have been described in recent years. The aim of our study was to characterize the effect of stilbene derivatives on single-chloride channel activity in the inner mitochondrial membrane. The measurements were performed after the reconstitution into a planar lipid bilayer of the inner mitochondrial membranes from rat skeletal muscle (SMM), rat brain (BM) and heart (HM) mitochondria. After incorporation in a symmetric 450/450 mM KCl solution (cis/trans), the chloride channels were recorded with a mean conductance of 155 ± 5 pS (rat skeletal muscle) and 120 ± 16 pS (rat brain). The conductances of the chloride channels from the rat heart mitochondria in 250/50 mM KCl (cis/trans) gradient solutions were within the 70–130 pS range. The chloride channels were inhibited by these two stilbene derivatives: 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) and 4-acetamido-4′-isothiocyanostilbene-2,2′-disulfonic acid (SITS). The skeletal muscle mitochondrial chloride channel was blocked after the addition of 1 mM DIDS or SITS, whereas the brain mitochondrial channel was blocked by 300 μM DIDS or SITS. The chloride channel from the rat heart mitochondria was inhibited by 50–100 μM DIDS. The inhibitory effect of DIDS was irreversible. Our results confirm the presence of chloride channels sensitive to stilbene derivatives in the inner mitochondrial membrane from rat skeletal muscle, brain and heart cells.

6

Nitroso-sulfide coupled signaling triggers specific vasoactive effects in the intrarenal arteries of patients with arterial hypertension

64%

Cacanyiova S., Berenyiova A., Balis P., Kristek F., Grman M., Ondrias K., Breza J., Breza Jr J.

Journal of Physiology and Pharmacology

|

2017

|

tom 68

|

nr 4

Ograniczanie wyników

4 Journal of Physiology and Pharmacology

1 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

6 Ondrias K.

4 Cacanyiova S.

4 Kristek F.

3 Grman M.

2 Berenyiova A.

2 Malekova M.

1 Balis P.

1 Bednarczyk P.

1 Breza J.

1 Breza Jr J.

1 Choma K.

1 Dolowy K.

1 Drapala A.

1 Drobna M.

1 Kominkova V.

1 Koszela-Piotrowska I.

1 Koszelewski D.

1 Kunz W. S.

1 Malekova L.

1 Ostaszewski R.

1 Szewczyk A.

1 Tomasova L.

1 Ufnal M.

2 2017

1 2016

1 2013

1 2012

1 2007

Blood pressure-independent hypotrophy of the heart, kidneys and conduit arteries after 7-nitroindazole administration to Wistar rats from the prenatal period to adulthood

Effect of chronic neuronal nitric oxide-synthase inhibition on arterial function and structure in spontaneously hypertensive rats

The adaptive role of nitric oxide and hydrogen sulphide in vasoactive responses of thoracic aorta is triggered already in young spontaneously hypertensive rats

Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats

Stilbene derivatives inhibit the activity of the inner mitochondrial membrane chloride channels

Nitroso-sulfide coupled signaling triggers specific vasoactive effects in the intrarenal arteries of patients with arterial hypertension