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1

Wplyw nieodzownych fosfolipidow [EPL] na niektore parametry farmakologiczne lekow narkotycznych u myszy

100%

Samochowiec J., Adamek B.

Herba Polonica

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1992

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tom 38

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nr 2

85-92

Celem pracy było zbadanie wpływu nieodzownych fosfolipidów (EPL) na przebieg narkozy halotanowej (Halothan), enfluranowej (Ethrane) i izofluranowej (Forene) u myszy. Uzyskane rezultaty wskazują, że EPL działa korzystnie, łagodząc objawy niepożądane stosowanych narkotyków wziewnych oraz poprawiając parametry narkozy, takie jak: czas zasypiania i wybudzania oraz czas szybkości orientacji.

2

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Ocena wystepowania Pneumocystis carinii u chorych zakazonych wirusem HIV w oparciu o wyniki trzech metod diagnostycznych

71%

Ciarkowska J., Spausta G., Wiczkowski A., Adamek B., Beniowski M.

Wiadomości Parazytologiczne

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2001

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tom 47

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nr 3

543-548

The frequency of Pneumocystis carinii occurrence in BAL of 38 HIV-infected patients was determined with three different method. BAL sediments were stained with Giemsa method, silvered according to Gomori-Grocott method and studied with indirect immunofluorescence assay. Using Giemsa method staining Pneumocystis carinii was diagnosed in 81,6% of patients, in Gomori-Grocott method - in 31,6% of patients, but results of indirect immunofluorescence assay were positive only in 23,7%. In our study staining BAL sediments with Giemsa method allowed to detect Pneumocystis carinii in the highest percentage of examined patients.

3

Czestosc wystepowania Borrelia burgdorferi sensu lato u kleszczy Ixodes ricinus z okolic Tarnowskich Gor

61%

Spausta G., Wiczkowski A., Ciarkowska J., Strzelczyk J., Trapp G., Adamek B., Zalewska-Ziob M.

Wiadomości Parazytologiczne

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2003

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tom 49

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nr 1

39-45

Prevalence of Borrelia burgdorferi sensu lato in ticks, Ixodes ricinus in Tarnowskie Góry district. Borrelia burgdoiferi is an aetiological factor of borreliosis (Lyme disease). The main vectors of Borrelia burgdoiferi are larvae, nymphs, and females of Ixodes ricinus. The aim of this paper was to analyse infection parameters of Borrelia burgdoiferi in a selected populations of Ixodes ricinus. The study was conducted in Tarnowskie Góry administrative district (Krupski Młyn, Zielona, Lubliniec, Tarnowskie Góry, Świerklaniec, Tworóg, and Zbrosławice). A total of 85 ticks were collected with a piece of cloth dragged over the vegetation. The Borrelia burgdoiferi infection was confirmed with a PCR method, using flagellin protein gene DNA amplification. DNA of Borrelia burgdeiferi sensu lato was present in 14 ticks, which constituted 16.5% of the population studied. The percentage of infected females and nymphs was 26.8%, 22.2%, and 5.6%, respectively. A high prevalence of the pathogen (50%) was in ticks revealed in the recreation areas and the community forest in Świerklaniec.

4

The oxidative DNA damage analysis in coke oven workers

61%

Adamek B., Kasperczyk J., Wiczkowski A., Steplewski Z., Strzelczyk J., Gawron K.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr Suppl.2, Part 1

Polycyclic aromatic hydrocarbons (PAHs) are DNA adducts forming carcinogens. The DNA adducts, especially 8-oxoguanine (8-oxoG), are the established biomarker of environmental genotoxic compounds exposure. The aim of this study was to determine the 8-oxoG presence in peripheral blood lymphocytes of 27 coke oven workers and 21 rural area inhabitants comparison. The study and control groups were not significantly different according to %8-oxoG-positive lymphocytes. In the control group the difference between smokers and non-smokers was significant (p<0,01). %8-oxoG in non-smokers from the study and control groups were significantly different (p<0,009). The occupational exposure and smoking cigarettes are important oxidative DNA damage causing factors.

5

Clinical and prognostic value of hTERT mRNA expression in patients with non-small-cell lung cancer

61%

Zalewska-Ziob M., Dobija-Kubica K., Biernacki K., Adamek B., Kasperczyk J., Brulinski K., Ostrowska Z.

Acta Biochimica Polonica

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2017

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tom 64

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nr 4

6

The activity of antioxidant enzymes in colorectal adenocarcinoma and corresponding normal muscoa

51%

Strzelczyk J. K., Wielkoszynski T., Krakowczyk L., Adamek B., Zalewska-Ziob M., Gawron K., Kasperczyk J., Wiczkowski A.

Acta Biochimica Polonica

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2012

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tom 59

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nr 4

Oxidative stress is one of several factors which contribute to the development of colorectal carcinogenesis. The aim of the study was an assessment of the activity of antioxidant enzymes in tumour and corresponding normal distal mucosa in a group of patients with colorectal adenocarcinoma. Samples of tumour and corresponding normal mucosa were obtained during a resection of colorectal cancer from 47 patients aged between 26 and 82 years. The average distance of corresponding normal distal mucosa from the tumour was 4.49 cm. Activities of antioxidant enzymes: superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and catalase (CAT) were measured in tissue homogenates. The patients were grouped according to the tumour stage (Duke's staging), grading, localization, and size of tumour, as well as age and sex. Statistical analysis was performed. The activity of SOD and GPx was considerably increased, while the activity of GST decreased significantly in tumour as compared with normal mucosa. GR activity in colorectal cancer was evidently higher in tumours of proximal location compared with the distal ones. The distance of corresponding normal distal mucosa from the tumour was analyzed and related to all assayed parameters. A decreased GST activity was observed in corresponding normal mucosa more than 5 cm distant from the tumour in patients with CD Duke's stage. The higher activity of superoxide dismutase and glutathione peroxidase in tumour compared to corresponding normal mucosa could indicate higher oxidative stress in colorectal adenocarcinoma cells.

7

Detection of CagA gene in Helicobacter pyroli infected children

51%

Zalewska-Ziob M., Sliupkas-Dyrdac E., Wiczkowski A., Mazurek U., Adamek B., Sikora A., Kalita B., Ilczuk D., Obuchowicz A.

Cellular and Molecular Biology Letters

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2001

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tom 06

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nr 3A

797

8

IFNalpha2a influence on the mitotic activity in the regenerating rat liver

51%

Adamek B., Ziolkowski A., Izdebska-Straszak G., Spausta G., Ciarkowska J., Trapp G., Gawron K., Wiczkowski A.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

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