The study offers a new approach to investigate age-related changes in duration discrimination in millisecond time domain. Forty healthy subjects: young (aged: 20–29 years) and elderly (aged: 61–71 years) were studied using Mismatch Negativity (MMN) paradigm. White-noise bursts of two different durations (50 ms and 10 ms) were presented binaurally in 2 oddball blocks. In one block (increment condition, IC), the repetitive sequence of 10 ms standards was interspersed by occasional 50 ms deviants. The order was reversed in the second block (decrement condition, DC). MMN was elicited in two age groups. The amplitudes were significantly higher in young than in elderly participants for both conditions, but higher in IC than in DC. Moreover, the IC resulted in significantly shorter latencies of MMN peak than the DC for two groups. These results suggest that the MMN is a good indicator for detection of changes in stimulus duration in some tens of milliseconds which corresponds to results of previous psychophysical studies. However, some subject-related factors (e.g., age, gender), as well as procedure-related ones (e.g. stimulus presentation condition) have to be taken into account while designing a reliable measurement in the future timing studies. Supported by the grant: INNOTECH-K1/IN1/30/159041/NCBR/12.
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