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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Phytonutrients of bilberry fruit and saskatoon berry in the prevention and treatment of dyslipidemia

100%
Kopcekova J., Mrazova J.
Roczniki Państwowego Zakładu Higieny
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2022
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tom 73
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nr 3
The epidemiologic studies from the recent years indicate that high consumption of foods rich in bioactive compounds has a positive effect on human health and could diminish the risk of numerous diseases, such as cancer, heart disease, stroke, Alzheimer’s disease, diabetes, cataracts, and even diseases related to age. From all species of fruit, definitely consumption of berries due to its high content of bioactive constituents prevents the risk of cardiovascular disease, oxidative stress and diabetes. The primary phenolic compounds in berries are flavonoids, particularly the anthocyanins. They have potential preventative and therapeutic effects on many diseases such as cancers, inflammation and cardiovascular diseases, obesity, neurodegenerative pathologies, and muscular degeneration. Bilberry fruits have been an important part of local diets in many countries, including Slovakia. They are valued for their pleasant taste and aroma and are often processed into jams, preserves, juices, and alcoholic beverages. In the last two decades, the Saskatoon berry has been cultivated in many parts of the world for its suitability for various food products and due to its high content of nutrients and polyphenols. Cardiovascular disease (CVD) remains the world’s leading cause of morbidity and mortality. Dyslipidemia, which results from one or more abnormalities of blood lipids metabolism, remains a major key factor for progression of CVD and leads to the development of atherosclerotic plaques. The aim of this review is to compare and summarize the research evidence on the potential of bilberries and saskatoon berries with an emphasis on recent studies in humans in improving cardiovascular risk factors especially dyslipidemia.
2
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Evaluation of cardiovascular diseases risk factors in a group of men hospitalized after myocardial infarction

100%
Mrazova J., Kopcekova J.
Roczniki Państwowego Zakładu Higieny
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2022
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tom 73
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nr 4
Background. Cardiovascular diseases (CVD) due to their large expansion and high mortality represent a serious problem for society. Ischemic heart disease and myocardial infarction is the leading cause of death and morbidity in both men and women in Europe, although is lower in women than in men. Objective. To evaluate the occurrence of cardiovascular risk factors and the impact of selected dietary habits on lipid profile and body mass index in adult men hospitalized after myocardial infarction in the Cardiocenter Nitra in 2010-2020. Material and Methods. This study was focused on a group of adult men (n = 193) in the age range of 25 to 85 years. Patients were selected using the method of random selection from the database of those hospitalized in the Cardiocenter Nitra in 2010-2020. We evaluated to influence of risk factors of cardiovascular diseases on lipid profile and BMI of men. The questionnaire for the detection of dietary habits and life style of respondents was used. It was applied individually by interviewer and was compiled by the Institute of Nutrition and Genomics. Data collection was carried out simultaneously with a somatometric and biochemical examination of the respondents ensured by the Cardiocenter Nitra. The following parameters were tested: total cholesterol (T-C), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C) and triacylglycerols (TAG) and glucose (GLU) by automatic biochemical analyzer BioMajesty® JCA-BM6010/C. We used statistical analysis of Statistica Cz version 10 and one-way ANOVA, followed by Tukey's post hoc test. Results. The most important risk factor is clearly the lifestyle of the respondents. Only 11% of the respondents had an optimal BMI, 51% were classified as overweight and up to 38% had a BMI higher than 30 kg.m-2. Improper dietary habits and lack of physical activity contributed to the development of hypertension and hypercholesterolaemia in the majority of respondents. Statistically significant changes in HDL-cholesterol scores were found to be associated with respondents’ BMI (p< 0.01). Conclusions. Studied men after the myocardial infarction should attach particular importance to their diet and lifestyle, which significantly affect BMI, blood lipid parameters and the inflammatory process as risk factors responsible for the etiopathogenesis of cardiovascular diseases.
3

Pig meat indices as influenced by increased levels of organic selenium

81%
Bobcek R., Bobcek B., L'ahucky R., Mrazova J.
Annals of Animal Science. Supplement
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2006
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nr 2/1
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Obesity, smoking status and their relationships in selected population groups

81%
Lenartova P., Gazarova M., Mrazova J., Kopcekova J.
Roczniki Państwowego Zakładu Higieny
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2021
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tom 72
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nr 3
5
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Evaluation of lipoproteins and high sensitivity CRP in consumers of bakery products

81%
Lenartova P., Gazarova M., Kopcekova J., Mrazova J.
Roczniki Państwowego Zakładu Higieny
|
2024
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tom 75
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nr 1
Background. In recent years, a wider range of bakery products with a lower glycaemic response can be observed in the food industry. This contributes to the provision of a wider range of cereal bakery products. The gradual increase in the consumption of brown bread is significant, but despite this, white bread remains a part of the typical Western diet. Studies showed high intake of carbohydrates increase TG levels by enhancing hepatic synthesis of very low-density lipoprotein (VLDL) and decrease activity of lipoprotein lipase. White bread consumption has been therefore associated with an unhealthy lifestyle. Objective. The aim of this study was to assess the influence of the consumption of gluten bakery products on lipids and inflammatory parameters of the probands. Material and Methods. The monitored group consisted of 30 probands from the general population. The average age of the monitored group was 29.7 years. The intervention dose consisted of a different combination of several types of bakery products containing gluten (bread, pastries, soft pastries) within the individual weeks of consumption, while the intervention lasted 6 weeks. An intervention dose of 150 to 200 g per day was set for women and 200 to 250 g per day for men. Biochemical blood parameters were determined using a fully automatic Biolis 24i Premium blood serum biochemical analyzer, by end-point photometry method. We tested the differences between the biochemic parameters by one-factor analysis of variance (ANOVA) and compared them by Tuckey’s Post Hoc Test. Results. The measurement of the lipid profile showed that the average levels of total cholesterol (TC) were above the reference value (<5.00 mmol. l-1) in each of the three performed measurements (P˂0.01). In the case of LDL, we found a similar trend in the development of lipoprotein values, while we positively evaluate a slight reduction of LDL in the measurement immediately after the intervention (P˂0.001). Certain changes during the study were also noted in HDL parameters with high statistical significance (P˂0.001). During the TG analysis, we found that probands have normal values (0.45-2.70 mmol. l-1). A reduction in average TG values was achieved in individual measurements, but without statistical significance (P˃0.05). In high sensitivity CRP (hs-CRP) parameters was achieved a bell curve of the development of average values, with a maximum measured immediately after the intervention. Changes in hs-CRP during the study were without statistical significance (P˃0.05) Conclusions. The measurement of the lipid profile showed that the average levels of TC, LDL and HDL, there were above the reference value in each of the three measurements performed. Through the analysis of TG, we found normal values and during the study there was a slight decrease. Furthermore, we found that intervention with bakery products containing gluten was associated with an increase in hs-CRP levels in our probands.
6
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Biochemical parameters as monitoring markers of the inflammatory reaction by patients with chronic obstructive pulmonary disease (COPD)

71%
Lenartova P., Kopcekova J., Gazarova M., Mrazova J., Wyka J.
Roczniki Państwowego Zakładu Higieny
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2017
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tom 68
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nr 2
Background. Chronic obstructive pulmonary disease (COPD) is an airway inflammatory disease caused by inhalation of toxic particles, mainly cigarette smoking, and now is accepted as a disease associated with systemic characteristics. Objective. The aim of this work was to investigate and compare selected biochemical parameters in patients with and without COPD. Material and Methods. Observation group consisted of clinically stable patients with COPD (n = 60). The control group was healthy persons from the general population, without COPD, who were divided into two subgroups – smokers (n = 30) and non-smokers (n = 30). Laboratory parameters were investigated by automated clinical chemistry analyzer LISA 200th. Results. Albumin in our measurements showed an average value of 39.55 g.l-1 in the patient population; 38.89 g.l-1 in smokers and in non-smokers group 44.65 g.l-1. The average value of pre-albumin in the group of patients was 0.28 ± 0.28 g.l-1 and 0.30 ± 0.04 g.l-1 in smokers group. The average value of the orosomucoid in patients was about 1.11 ± 0.90 mg.ml-1. In the group of smokers, the mean value of orosomucoid was 0.60 ± 0.13 mg.ml-1. The level of C-reactive protein (CRP) in the patient group reached an average value of 15.31 ± 22.04 mg.l-1, in the group of smokers was 5.18 ± 4.58 mg. l-1. Prognostic inflammatory and nutritional index (PINI) in the group of patients showed a mean value of 4.65 ± 10.77 and 0.026 ± 0.025 in smokers. Conclusions. The results of this work show, that the values of index PINI in COPD patients are significantly higher than in smokers (P <0.001). This along with other monitored parameters indicative inflammation as well as a catabolic process that occurs in the organism of patients with COPD.
7

Effect of magnesium oxide supplementation on carcass value and meat quality of pigs with malignant hyperthermia

71%
Bobcek B., Bahelka I., Bobcek R., Mrazova J., Demo P.
Annals of Animal Science. Supplement
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2006
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nr 2/1
8
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Analysis of visceral fat in patients with chronic obstructive pulmonary disease (COPD)

71%
Lenartova P., Habanova M., Mrazova J., Chlebo P., Wyka J.
Roczniki Państwowego Zakładu Higieny
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2016
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tom 67
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nr 2
Background. Cigarette smoking is a major public health problem, which leads to the formation of chronic obstructive pulmonary disease (COPD) and is one of the main causes of avoidable death and disability worldwide. Objective. The aim of study was analysis and comparison of the visceral fat in the body of the three groups of subjects (non-smokers, smokers and COPD patients) by Tanita Viscan 140. Material and Methods. The control group was composed of: (1) non-smokers (n=30), consisted of 13 males (43.4%) and 17 women (56.6%) - the average age was 52 ± 6.51 years and (2) smokers (n=30), consisted of 12 men (40%) and 18 women (60%) – the average age 46.53 ± 9.22 years. Study group consisted of patients with COPD (n=60), which consisted of 48 men (80%) and 12 women (20%). Mean age was 69.25 ± 9.90 years. The measurement of visceral fat by Tanita Viscan device 140, which uses bioelectrical impedance analysis to measure fat in the abdomen of the patient in the supine position. Results. High levels of visceral fat (women from 36.9% to 52.3% and more, men from 27.1% to 40.3% or more) were observed in 19 patients (3 women and 16 men), with 19 smokers (10 women and 9 men) and non-smokers in 22 subjects (10 women and 12 men). The average value of waist circumference measured with a Tanita Viscan 140 was in the group of patients 96.38 ± 12.27 cm, in the group of smokers 95.23 ± 10.12 cm and in group of non-smokers 96.86 ± 10.88 cm. Conclusions. The results of our work are of great importance for the health assessment not only among patients with COPD but also in the group of smokers. Therefore it would be appropriate to remind the general public, eg. by campaign for chronic obstructive pulmonary disease and its serious complications and reduce the life quality of these patients and thus help protect human health and in particular young people from the harmful effects of tobacco products.
9
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The effect of regular chokeberry juice consumption on anthropometric and lipid parameters in women with overweight or obesity

71%
Mrazova J., Kopcekova J., Habanova M., Gazarova M., Lenartova P.
Roczniki Państwowego Zakładu Higieny
|
2024
|
tom 75
|
nr 2
Background. Aronia melanocarpa is nowadays valued for its high content of biologically active substances, the main group of which are polyphenols, which include anthocyanins, flavonols, flavanols, proanthocyanidins and phenolic acids. From the available sources, we can conclude that extracts and juices from black chokeberry have a great potential in human nutrition and influence on their health. Objective. The research was to evaluate the effect of regular consumption of 100% organic chokeberry juice on selected anthropometric and lipid parameters of overweight or obese women. Material and Methods. A clinical study consisted of 19 women with overweight and obesity, age from 44 to 63. The probands consumed 50 ml of chokeberry juice daily for 8 weeks as part of their regular diet. Body composition and biochemical indicators were monitored before consumption, after 4 and 8 weeks of nutritional intervention. Body composition was determined using multifrequency bioelectrical impedance analysis (MFBIA) – InBody 720. Biochemical analyzes of blood serum were performed using standard methods in an accredited laboratory using automatic biochemical analyzer a BioMajesty JCA-BM6010/C. Results. The monitored group of probands is characterized by menopausale and postmenopausale women, overweight or obese women with hypercholesterolemia without pharmacological treatment. Statistically significant differences (p<0.05) were observed when evaluating the amount of body fat (BFM) of the probands before the start of consumption and after the consumption of chokeberry juice. We noted a statistically significant reduction especially in the assessment of visceral fat (VFA) (p<0.001). There were no fundamentally significant changes in the lipid profile of women in this intervention study. With short-term consumption of chokeberry juice (after 4 weeks), we recorded an average reduction in total cholesterol and LDL-cholesterol, but without statistical significant. We also focused on the evaluation of the inflammatory marker CRP and noted a significant beneficial reduction of CRP (p˂0.05). Conclusions. In the research, we evaluated the effect of 8 weeks consumption of 100% chokeberry juice on selected anthropometric parameters, focusing on changes in visceral fat and total fat in overweight and obese women. In conclusion, we can state that the regular consumption of chokeberry juice has a beneficial effect on fat tissue in women of reproductive age, which can reduce the risk of cardiovascular diseases.
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The relationship between seeds consumption, lipid profile and body mass index among patients with cardiovascular diseases

61%
Kopcekova J., Lenartova P., Mrazova J., Gazarova M., Habanova M., Jancichova K.
Roczniki Państwowego Zakładu Higieny
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2021
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tom 72
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nr 2
11
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Consumption of different types of bakery products and its effect on visceral fat area in healthy population

61%
Gazarova M., Lenartova P., Kopcekova J., Mrazova J., Holovicova M., Chlebova Z., Wyka J.
Roczniki Państwowego Zakładu Higieny
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2018
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tom 69
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nr 4
Background. Bread is one of the world’s most consumed food commodity. However, in the last years consumption of bread and bakery products has declined, especially in the Western population. The reason for concern is the weight gain and presence of gluten in these products. Gluten is unacceptable in the diet only in patients with celiac disease who are forced adhere the gluten-free diet all the time. The consequences of gluten-free diet in healthy people are the subject of many recent studies. Objective. The aim of this study was to evaluate the changes of visceral fat area in the general population after 6 weeks of consumption of gluten-free, gluten-containing and whole-grain bread and other bakery products. Material and Methods. The study group consisted of 120 volunteers divided into four subgroups each with 30 subjects. Anthropometric measurements were made using the InBody 720 (Biospace Co. Ltd., Seoul, Republic of Korea). We used the Lookin’Body 3.0 software to process the results. The collected data from anthropometric measurements were evaluated statistically and graphically in Microsoft Office Excel 2010 (Los Angeles, CA, USA). Results. After the intervention we found out that visceral fat area values increased in probands consuming gluten-free and gluten-containing bakery products, but these changes were not significant (P>0.05; 72.7±29.18 cm2 vs 73.26±30.32 cm2 and 69.6±34.06 cm2 vs 70.34±32.33 cm2, respectively). In whole-grain and control group we observed a reduction in visceral fat area, in the control group there was a significant change (P>0.05 – 91.58±33 cm2 vs 90.47±34.37 cm2 and P<0.05 – 77.3±21.65 cm2 vs 75.56±21.87 cm2, respectively). After the intervention the visceral fat area values increased in gluten-free group in 57% of subjects, in gluten group in 73% of subjects and in the whole-grain group in 43% of volunteers. Although visceral fat area values had inceased in gluten-free and gluten-containing groups, the number of probands with reference values increased from 80% to 86% in the gluten-free group and from 43% to 66% in the gluten-containing group. In the whole-grain group we found decrease in number of subjects with reference values of visceral fat area (from 70% to 63%). There were no changes in the control group (86% vs. 86%). Conclusions. Consumption of different types of bakery products has mostly changed the visceral fat area values in a positive direction.
12
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Benefits of sea buckthorn juice consumption in women of productive age with hypercholesterolemia

61%
Kopcekova J., Mrazova J., Fatrcova-Sramkova K., Habanova M., Gazarova M., Lenartova P.
Roczniki Państwowego Zakładu Higieny
|
2023
|
tom 74
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nr 2
Background. Sea buckthorn contains almost 200 nutrients and bioactive substances, including phenolic compounds such as flavonoids, vitamins, proteins, amino acids, minerals, alkaloids, chlorophyll derivatives, amines, organic acids, fatty acids and phytosterols. Human and animal studies suggest that sea buckthorn may have a variety of beneficial effects: cardioprotective, antiatherogenic, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral and antiinflammatory. Objective. The aim of this study was to evaluate the effect of regular consumption of 100% sea buckthorn juice on the risk factors of cardiovascular diseases in women of productive age with hypercholesterolemia. Material and Methods. A clinical study involved 19 women with a mean age of 54.06 ±2.97 years who consumed 50 mL of sea buckthorn juice daily for 8 weeks. Anthropometric and biochemical parameters in blood serum were monitored before the start of sea buckthorn consumption and after 8 weeks of consumption. Body composition was determined using an multifrequency analyzer InBody720. Routine biochemical analyzes were performed by standard methods in an accredited laboratory of the University Hospital by automatic biochemical analyzer BioMajesty JCA-BM6010/C. Statistical comparison between individual measurements was performed using a paired t-test, using Statistica Cz version 10 (TIBCO Software, Inc., Palo Alto, CA, USA). Results. We observed significant decrease of body weight, body mass index (P<0.05), body fat and visceral fat (P<0.001) after 8 weeks of consumption of 100% sea buckthorn juice. In this intervention study, we observed a significant decrease in low-density cholesterol (P˂0.05) and a significant increase in high-density cholesterol (P˂0.001). The level of triglycerides was similar at the end of the study (P>0.05). After the intervention, we observed decrease of orosomucoid, immunoglobulin A, immunoglobulin G, immunoglobulin M (P<0.001) and C-reactive protein (P<0.01). Conclusions. The obtained results support the hypothesis that the daily consumption of sea buckthorn juice for eight weeks could contribute to the beneficial effects of reducing the risk of cardiovascular diseases, such as the reduction of body and visceral fat, LDL-C, CRP and the increase of HDL-C.
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