Wyniki wyszukiwania

1

Triple immunofluorescence labeling of atherosclerotic plaque components in apoE-LDLR mice

100%

Gajda M., Jawien J., Mateuszuk L., Lis G. J., Radziszewski A., Chlopicki S., Litwin J. A.

Folia Histochemica et Cytobiologica

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2008

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tom 46

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nr 2

143-146

2

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Conjugated linoleic acid has no effects on atherosclerosis but induces liver steatosis in apoE/LDLR -/- mice fed a fructose-rich diet

100%

Kostogrys R. B., Franczyk-Zarow M., Maslak E., Gajda M., Mateuszuk L., Chlopicki S.

Journal of Pre-Clinical and Clinical Research

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2010

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tom 04

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nr 2

3

Effects of conjugated linoleic acid (CLA) on development of atherosclerosis in ApoE/LDLr -/- mice

100%

Kostogrys R. B., Franczyk-Zarow M., Bieniek M. I., Maslak E., Gajda M., Mateuszuk L., Chlopicki S.

Journal of Pre-Clinical and Clinical Research

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2010

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tom 04

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nr 2

4

Platelets augment respiratory burst in neutrophils activated by selected species of gram-positive or gram-negative bacteria

84%

Miedzobrodzki J., Panz T., Plonka P. M., Zajac K., Dracz J., Pytel K., Mateuszuk L., Chlopicki S.

Folia Histochemica et Cytobiologica

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2008

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tom 46

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nr 3

383-388

5

Effect of curcumin on atherosclerosis in apoE-LDLR - double knockout mice

84%

Olszanecki R., Jawien J., Gajda M., Mateuszuk L., Gebska A., Korabiowska M., Chlopicki S., Korbut R.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 4

It is widely appreciated that inflammation and oxidant stress contribute to atherogenesis. Curcumin, a polyphenolic natural compound has been reported to possess anti-inflammatory and anti-oxidant actions. We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR - double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid). Curcumin (purity 98%), premixed with diet, was given for 4 months at a dose of 0.3 mg/per day/per mouse. In this model curcumin inhibited atherogenesis, measured both by "en face" method (25,15±2,9% vs. 19,2±0,6%, p<0,05) and "cross-section" method (565867±39764 µm2 vs. 299201±20373 µm2, p<0,05). Importantly, curcumin influenced neither the concentrations of cholesterol and triglycerides in blood nor animal body weight. To our knowledge, this is the first report that shows the anti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR - double knockout mice.

6

Inhibition of nuclear factor-kappaB attenuates atherosclerosis in apoE-LDLR - double knockout mice

84%

Jawien J., Gajda M., Mateuszuk L., Olszanecki R., Jakubowski A., Szlachcic A., Karabiowska M., Korbut R.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 3

Nuclear factor - B (NF-B) is a good therapeutic target for cardiovascular disease and numerous efforts are being made to develop safe NF-B inhibitors. Nowadays many authors address NF-B as a major therapeutic target in atherosclerosis, especially for preventive measures, in the light of two main hypothesis of atherosclerosis: oxidation and inflammation. We hypothesized that ammonium pyrrolidinedithioocarbamate (PDTC) - a well-known inhibitor of NF-B could inhibit the development of atherosclerosis in this experimental model. We used apoE/LDLR - DKO mouse model, which is considered as a one of the best models to study the anti-atherosclerotic effect of drugs. In this model PDTC inhibited atherogenesis, measured both by "en face" method (25,15±2,9% vs. 15,63±0,6%) and "cross-section" method (565867±39764 µm2 vs. 291695±30384 µm2). Moreover, PDTC did not change the profile of cholesterol and triglycerides in blood. To our knowledge, this is the first report that shows the effect of PDTC on atherogenesis in gene-targeted apoE/LDLR - double knockout mice.

Ograniczanie wyników

2 Folia Histochemica et Cytobiologica

2 Journal of Physiology and Pharmacology

2 Journal of Pre-Clinical and Clinical Research

6 Mateuszuk L.

5 Chlopicki S.

5 Gajda M.

3 Jawien J.

2 Franczyk-Zarow M.

2 Korbut R.

2 Kostogrys R. B.

2 Maslak E.

2 Olszanecki R.

1 Bieniek M. I.

1 Dracz J.

1 Gebska A.

1 Jakubowski A.

1 Karabiowska M.

1 Korabiowska M.

1 Lis G. J.

1 Litwin J. A.

1 Miedzobrodzki J.

1 Panz T.

1 Plonka P. M.

1 Pytel K.

1 Radziszewski A.

1 Szlachcic A.

1 Zajac K.

2 2010

2 2008

2 2005

Triple immunofluorescence labeling of atherosclerotic plaque components in apoE-LDLR mice

Conjugated linoleic acid has no effects on atherosclerosis but induces liver steatosis in apoE/LDLR -/- mice fed a fructose-rich diet

Effects of conjugated linoleic acid (CLA) on development of atherosclerosis in ApoE/LDLr -/- mice

Platelets augment respiratory burst in neutrophils activated by selected species of gram-positive or gram-negative bacteria

Effect of curcumin on atherosclerosis in apoE-LDLR - double knockout mice

Inhibition of nuclear factor-kappaB attenuates atherosclerosis in apoE-LDLR - double knockout mice