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1

Diverse effect of PMCA (2 and 3 isoform) blocking in differentiated and non-differentiated PC 12 cells

100%
Szemraj J., Kawecka I., Zylinska L.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
2

The isoform- and location-dependence of the functioning of the plasma membrane calcium pump

100%
Zylinska L., Kawecka I., Lachowicz L., Szemraj J.
Cellular and Molecular Biology Letters
|
2002
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tom 07
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nr 4
The plasma membrane is a specialised multi-component structure with inter- and intracellular signalling functions. Ca2+ plays a crucial role in cellular physiology, and an ATP-driven plasma membrane calcium pump (PMCA) plays the greatest role in the maintenance of a low free Ca2+ concentration in the cytoplasm. The enzyme is coded by four separate genes (PMCA 1-4), and, due to alternative splicing, more than 20 variants can exist. PMCA 1 and 4 isoforms are present in almost all tissues, whereas PMCA 2 and 3 are found in more specialised cell types. The variants differ primarily in their regulatory regions, thus the modulation of calcium pump activity strongly depends on the isoform and the membrane composition. The unique function of PMCA isoforms was confirmed using the practical experimental models - a rat pheochromocytoma cell line, a human neuroblastoma cell line, or, more recently, knockout mice. In addition, based on the finding that PMCA could interact with several specific signaling proteins, it was concluded that its location in defined sites of the cell membrane could be a prerequisite for efficient intercellular communication.
3

Neuroactive steroids regulation of calcium pump transport activity in stable transfected PC12 cells

100%
Kawecka I., Szemraj J., Zylinska L.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
4

The effect of antisense oligonucleotide treatment of plasma membrane Ca2plus-ATPase in PC12 cells

100%
Szemraj J., Kawecka I., Bartkowiak J., Zylinska L.
Cellular and Molecular Biology Letters
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2004
|
tom 09
|
nr 3
Plasma membrane Ca2+-ATPase (PMCA), encoded by four separate genes, constitutes a high affinity system extruding Ca2+ outside the cell. The nerve growth factor-treated PC12 cell line possesses all four main PMCA isoforms. To evaluate the potential role of PMCA isoforms in the differentiation process, we transiently suppressed the expression of PMCA2 and 3 using the antisense oligonucleotides. In the transfected PC12 cells, we observed morphological changes, slowed neurite extension and diminished survival of the cells. The apparent transport activity and affinity of the calcium pump to Ca2+ were lower in the cells with suppressed PMCA2 and 3 isoforms than in the control cells. Moreover, in the transfected PC12 plasma membranes, the calcium pump was insensitive to stimulation by calmodulin. These findings suggest that PMCA2 and 3 isoforms may be involved in developmental and differentiation processes.
5

The effect of oxidative stress on NADPH oxidase function in human endothelial cells

88%
Kawecka I., Oszajca K., Brown G., Bartkowiak J., Szemraj J.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
6

Construction of new thrombolytic and antithrombotic agents

76%
Kawecka I., Chabielska E., Janiszewska G., Buczko W., Adamczewska W., Szemraj J.
Cellular and Molecular Biology Letters
|
2001
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tom 06
|
nr 3A
762
7
Content available remote

Sleep study in patients with overweight and obesity

76%
Namyslowski G., Scierski W., Mrowka-Kata K., Kawecka I., Kawecki D., Czecior E.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
|
nr 6
59-65
Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by repetitive collapse of the pharyngeal airway during sleep, which leads to oxygen desaturation, sleep fragmentation and daytime somnolence. Obesity is one of the most important risk factor for the development of OSAS. The exact mechanisms responsible for the relationship between obesity and OSAS are still unclear. The fat deposits in the pharynx region as well as the reduction in the lung volume have been considered as factors that might be responsible for the increase of the upper airway collapsibility. The aim of our study was to evaluate the correlation between the Body Mass Index (BMI) and sleep study parameters in overweight and obese patients suffering from breathing disturbances during sleep. We studied a group of 106 consecutive obese or overweight patients with a primary complaint of snoring or other breathing disturbances during sleep. In all cases, BMI and sleep studies (PolyMESAM) were examined. We evaluated relationship between the BMI and sleep study parameters such as Respiratory Disturbance Index (RDI), Apnea Index (AI), Desaturation Index (DI) and Average of Lowest Saturation (LSAT). The results showed the lack of significant statistical correlations between BMI and all the sleep parameters studied in the overweight patients and the statistical positive correlation between the BMI and RDI in the obese cases. We conclude that BMI determination may be considered as a simple, yet important predictor, of the OSAS in the group of obese patients.
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