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Role of calcitonin gene related peptide in the modulation of intestinal circulatory, metabolic and myoelectric activity during ischemia-reperfusion

100%
Pawlik W. W., Obuchowicz R., Biernat J., Sendur R., Jaworek J.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 4,2
2
Content available remote

Involvement of central and peripheral histamine H3 receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat

100%
Obuchowicz R., Pawlik M. W., Brzozowski T., Konturek S. J., Pawlik W. W.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 1,2
Data concerning cardiovascular effects of peripherally and centrally located histamine H3 receptor stimulation are contradictory, and despite excessive studies their role in the control of the cardiovascular function have not been cleared yet. Effect of histamine H3 receptors activation have been attributed to modulation of sympathetic system activity but exact role of peripherally and centrally located histamine H3 receptors stimulation in the modulation of vascular tone of the mesentery and intestinal metabolism remains unexplored. Aim of the present study was to evaluate the role of centrally and peripherally located histamine H3 receptors in the modulation of vascular tone of the mesentery and metabolic activity of intestinal tissue. In anesthetized rats total mesenteric blood flow (MBF), mucosal intestinal blood flow (LDBF), intestinal oxygen uptake (VO2) and arterial pressure (AP) were determined. Intestinal arterial conductance (C) was also calculated. Administration of the selective histamine H3 receptor agonist imetit (10 µmol/kg i.a) evoked marked changes in hemodynamic and metabolic parameters; MBF, LDBF, C and VO2 were significantly increased, whereas AP was significantly decreased. Pretreatment with histamine H3 receptor antagonist clobenpropit (4 µmol/kg i.a.) abolished imetit-induced circulatory and oxygen uptake responses. Clobenpropit (4 µmol/kg i.a.) alone failed to affect the MBF, LDBF, AP, C and VO2 values. Central administration of imetit (0.1 µmol i.c.v.) markedly increased AP and decreased MBF, LDBF, C and VO2. Pretreatment with histamine H3 receptor antagonist clobenpropit (0,4 µmol i.c.v.) diminished circulatory and metabolic responses to centrally injected imetit. Central histamine H3 receptors blockade by clobenpropit evoked no significant changes in the mesenteric arterial and mucosal microcirculatory blood flow, intestinal metabolism and mean arterial pressure. We conclude that, peripheral histamine H3 receptors when stimulated decreases vasoconstrictory tone of the mesenteric artery and precapillary structures and evokes increase of intestinal oxygen uptake. This might be in part due to inhibition of sympathetic postganglionic fibers vasopressor activity. Central histamine H3 receptor stimulation activates vasoconstrictory sympathetic adrenergic system with possible involvement of other, presumably non-histaminergic receptors system. At basal conditions neither central nor peripheral histamine H3 receptors are involved in the control of mesenteric macro - and microcirculation and intestinal oxygen consumption.
3

Sensory neurons and liver protection

86%
Biernat J., Sendur R., Obuchowicz R., Jaworek J., Zejc-Bajsarowicz M., Pawlik W. W.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
4

Sensory nerves as modulators of intestinal preconditioning

86%
Obuchowicz R., Pawlik M., Sendur R., Szczepanski W., Biernat J., Pawlik W. W.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
5

CGRP as mediator of circulatory and myoelectric changes observed in the small intestine subjected to ischemia and reperfusion [I-R]

86%
Sendur R., Biernat J., Obuchowicz R., Gajda M., Dembinski A., Warzecha Z., Pawlik W. W.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
6
Content available remote

Histamine H3 receptors modulate reactive hyperemia in rat gut

86%
Pawlik W. W., Obuchowicz R., Pawlik M. W., Sendur R., Biernat J., Brzozowski T., Konturek S. J.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 3
Reactive hyperemia (RH) is an abrupt blood flow increase following release from mechanical occlusion of an artery, with restoration of intra-arterial pressure. The mechanism of this postocclusion increase in blood flow in the gut is multifactorial. Relaxation of intestinal resistance vessels, observed during RH, may involve myogenic, metabolic, hormonal and neurogenic factors. Evidence exists that histamine is an important endogenous mediator of various functions of the gut, including blood flow. The vascular effects of histamine in the intestinal circulation are due its agonistic action on histamine H1, H2 and H3 receptors. In the present study the hypothesis was tested that peripheral histamine H3 receptors are involved in the mediation of RH in the intestinal circulation. In anesthetized rats, anterior mesenteric artery blood flow (MBF) was determined with ultrasonic Doppler flowmeter, and arterial pressure (AP) was determined with a transducer. The increase in the volume of blood accumulating during RH (RH-volume), the peak increase of arterial blood flow (RH-peak response) and the duration of the hyperemia (RH-duration) were used to quantify RH after occluding the anterior mesenteric artery for 30, 60 and 120 s. Hyperemia parameters were determined before and after administration of the selective histamine H3 receptor antagonist clobenpropit. Pretreatment with clobenpropit was without any effect on control MBF and AP but significantly reduced most of RH responses. These findings support the hypothesis that histamine H3 receptors do not play any role in the control of intestinal vasculature at basal conditions but these receptors participate in the intestinal hyperemic reaction in response to complete temporal intestinal ischemia.
7
Content available remote

Effects of peripherally and centrally applied ghrelin in the pathogenesis of ischemia-reperfusion induced injury of the small intestine

72%
Pawlik M. W., Obuchowicz R., Biernat J., Szczepanski W., Pajdo R., Kwiecien S., Brzozowski T., Konturek S. J., Pawlik W. W.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 4
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