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1

Profesor Ignacy Zenon Siemion, chemik, wybitny naukowiec i nauczyciel akademicki

100%
Szewczuk Z.
Analecta. Studia i Materiały z Dziejów Nauki
|
2015
|
tom 24
|
nr 2
2

18th Polish Peptide Symposium

63%
Szewczuk Z., Cebrat M.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr 1
3

Projektowanie nowych inhibitorow trombiny

63%
Szewczuk Z.
Biotechnologia
|
1994
|
nr 2
138-151
4

The investigation of [(4'-amino)-PHE]4-enkephalin conformation in water by the spectrofluorimetric procedure

51%
Jankowski A., Siemion I. Z., Szewczuk Z.
Acta Biochimica Polonica
|
1981
|
tom 28
|
nr 1
5

Analogi luliberyny i ich zastosowanie

51%
Szewczuk A., Kurowska E., Szewczuk Z.
Biotechnologia
|
2000
|
nr 2
161-173
6

Receptor luliberyny - struktura i funkcja.

51%
Szewczuk A., Kurowska E., Szewczuk Z.
Postępy Biologii Komórki
|
1999
|
tom 26
|
nr 4
827-840
7

Conformational stability of six truncated cHMG1a proteins studied in their mixture by H-D exchange and electrospray ionization mass spectrometry

51%
Petry I., Wisniewski J. R., Szewczuk Z.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 4
The high mobility group (HMG) proteins are abundant non-histone components of eukaryotic chromatin. The presence of C-terminal acidic tails is a common feature of the majority of HMG proteins. Although the biological significance of the acidic do­mains is not clear, they are conferring conformational and metabolic stability to the proteins in vitro. Moreover, the length and net charge of the acidic tails affect the strength of HMG protein interaction with DNA. Synthesis of an insect HMG protein by standard recombinant technology in bacteria leads to a mixture of the intact protein (cHMG1a-(1-113) (I)) and a series of its degradation products truncated at the C tail: cHMGla-(l-lll) (II); cHMG1a-(1-110) (III); cHMG1a-(1-109) (IV); cHMG1a-(1-108) (V); cHMG1a-(1-107) (VI); cHMG1a-(1-106) (VII). The proteins differ from each other only by the number of amino-acid residues at the C-terminal tail. We used H/D ex­change mass spectrometry to characterize the stability of the proteins directly in their mixture. The results show that the proteins I-V and VII have very similar conforma­tions. The protein VI is less compact and exchanges its protons faster than the others. It may be concluded that the C-terminal tail influences the conformation of the cHMGla protein and that individual residues in this part of the protein play a key role in its compactness.
8

The determination of thymopoietin conformation based on X-ray structure of a discontinuous thymopoietin-like motif of G-actin

51%
Siemion I. Z., Strug I., Szewczuk Z.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 3
The biologically active conformation of thymopoietin, based on X-ray data reported for discontinuous thymopoietin-like motif of G-actin, is proposed. The conformation is compared with that resulting from the prediction made by the method of Chou & Fasman (Annu. Rev. Biochem. 47, 251-276, 1978) and Rost & Sander (Methods Enzymol. 266, 525-539, 1996).
9

Design, synthesis and biological evaluation of a new bridged immunosuppressor

45%
Szewczuk Z., Wilczynski A., Petry I., Siemion I. Z., Wieczorek Z.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 4
A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-y-Abu-Asn- Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was de­signed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral im­mune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.
10

Evaluation of high temperature glycation of proteins and peptides by electrospray ionization mass spectrometry

45%
Stefanowicz P., Boratynski J., Kanska U., Petry I., Szewczuk Z.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 4
Recently Boratyński & Roy (Glycoconjugate J., 1998, 15, 131) described a fast and convenient procedure for the synthesis of glycoconjugates. In the present study we used ESI-MS and circular dichroism as tools to analyze non-enzymatic glycation prod­ucts of proteins and peptides. We discuss influence of reaction conditions on the rate of glycation of lysozyme. We analyze for the first time collision induced dissociation spectra of the obtained peptide conjugates.
11

Further investigations on thymopentin-like fragments of HLA-DQ and their analogs

45%
Szewczuk Z., Wieczorek Z., Stefanowicz P., Wilczynski A., Siemion I. Z.
Archivum Immunologiae et Therapiae Experimentalis
|
1997
|
tom 45
|
nr 4
12

Early detection of active glomerular lesions in dogs and cats using podocin

39%
Szczepankiewicz B., Paslawska U., Nowak M., Bachor R., Czyzewska-Buczynska A., Paslawski R., Szewczuk Z.
Journal of Veterinary Research
|
2019
|
tom 63
|
nr 4
13

Determination of agents from Saccharomyces boulardii culture inhibiting filamentation of Candida albicans

39%
Murzyn A., Lukaszewicz M., Dziadkowiec D., Stefanowicz P., Szewczuk Z., Krasowska A.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
14

Immunosuppressory activity of the cyclodimeric peptide with RGD-sequences

39%
Szewczuk Z., Buczek P., Stefanowicz P., Krajewski K., Wieczorek Z., Siemion I. Z.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 1
Our previous studies showed that the nonapeptide fragment of HLA-DQ of the sequence H-Thr-Pro-Gln-Arg-Gly-Asp-Val-Tyr-Thr-OH, located in the β164-172 loop, strongly sup­presses the humoral and cellular immune responses, while its shorter analogs, H-Arg-Gly-Asp-Val-OH, H-Arg-Gly-Asp-Val-Tyr-OH and H-Gln-Arg-Gly-Asp-Val-Tyr-OH show only a weak stimulatory activity in respect to the humoral immunological response. These fragments contain the Arg-Gly-Asp (RGD) sequence, known for its importance for cellular association phenomena. Based on the crystal structure of HLA-DR1, we also de­signed and synthesized a cyclic analog H-Cys-Arg-Gly-Asp-Val-Tyr-Cys-OH with restricted conformation, which strongly suppresses the immune response and selectively inhibits the avβ3 integrin, suggesting that the mechanism of the immunosuppressory action of the peptide is associated with inhibition of the integrin. In this paper we present the design and synthesis of the cyclodimeric peptide,L Arg-Gly-Asp-Arg-Gly-Asp, which is also known as a selective avβ3 inhibitor. The synthesized peptide strongly suppresses both the humoral and cellular immune response. The results support our hypothesis that the immunomodulatory activity of HLA-DQ fragments may be connected with their interac­tions with some particular integrins on the cell surface.
15
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Podocyturia jako nowy marker w diagnostyce uszkodzeń ciałek nerkowych w medycynie weterynaryjnej

33%
Szczepankiewicz B., Paslawska U., Slawuta P., Madej J. P., Nowak M., Bachor R., Marycz K., Gebarowski T., Czyzewska-Buczynska A., Szewczuk Z.
Życie Weterynaryjne
|
2019
|
tom 94
|
nr 10
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