Wyniki wyszukiwania

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Błony śluzowe - stan gotowości immunologicznej. Część I

100%

Kalinowska-Gacek E., Gierynska M.

Życie Weterynaryjne

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2009

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tom 84

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nr 01

2

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Błony śluzowe - stan gotowości mmunologicznej. Część II

100%

Gierynska M., Kalinowska-Gacek E.

Życie Weterynaryjne

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2009

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tom 84

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nr 02

3

Survival of Corynebacterium pseudotuberculosis within macrophages and induction of phagocytes death

81%

Stefanska I., Gierynska M., Rzewuska M., Binek M.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 1

143-149

Since C. pseudotuberculosis is a facultative intracellular pathogen the aim of this study was focused on evaluating mechanisms that allowed these bacteria to survive in macrophages and determining their influence on induction of cell death. The influence of Corynebacteria on the programmed cell death of macrophages was determined on the basis of induction the autophagy and apoptosis in the cultures of murine macrophage cell lines J774 infected with bacteria. Corynebacterium pseudotuberculosis strains could survive within macrophages more than 48 hours. During that time bacteria were released as a result of the process that lead to death of phagocytes. This property varied among studied strains. There was no increase of micro- tubule-associated protein I light chain 3 (MAP I LC3) activity in macrophages infected with examined strains comparing with uninfected cultures and cultures treated with autophagy inducer (rapamycin) that served as negative and positive controls, respectively. The study with confocal microscopy did not show the increasing of caspase-3 activity in the infected macrophages and their nucleus did not reveal the fragmentation.

4

Wykorzystanie metody real-time PCR do wykrywania DNA ludzkiego herpeswirusa typu 6

81%

Dzieciatkowski T., Przybylski M., Gierynska M., Luczak M.

Medycyna Doświadczalna i Mikrobiologia

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2008

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tom 60

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nr 3

259-265

5

Ectromelia virus similarly modulates TH1- and TH2-cytokine polarizing response of conventional dendritic cells from different mouse strains in vitro

71%

Szulc-Dabrowska L., Struzik J., Toka F. N., Nowak Z., Gierynska M.

Postępy Mikrobiologii. Suplement

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2017

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tom 56

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nr 1

6

The role of interferonogenic dsRNA viruses in the development of respiratory infections - Model investigations

71%

Malicki K., Spohr de Faundez I., Gierynska M., Popis A., Ngosa Toka F.

Annals of Warsaw Agricultural University. Veterinary Medicine

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1993

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tom 18

55-60

7

Mousepox: phenotypical characterization of immune cells in epidermis

71%

Spohr I., Kawiak J., Gierynska M., Popis A., Niemialtowski M. G.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

8

Mechanizmy zachowania homeostazy jelitowej przez autochtoniczne mikrobionty i probiotyki

61%

Binek M., Kizerwetter-Swida M., Ciosek A. A., Rzewuska M., Chrobak-Chmiel D., Gierynska M.

Medycyna Weterynaryjna

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2016

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tom 72

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nr 10

Intestinal microbes are taxonomically diverse and constitute an ecologically dynamic microbiom interactively performing various physiological and physiopathological processes. It has been proposed that normal intestinal microbiotas play a critical role in the host’s metabolic homeostasis and immune tolerance. The modulation of intestinal microbiota populations by prebiotics, probiotics, and synbiotics may be beneficial for the host’s health. Under certain conditions, the intestinal microbiota and the host’s homeostasis can be restored by introducing bacteria that co-mediate anti-inflammatory responses. Commensal microbes and probiotics exert their beneficial effect by at least three mechanisms. These include – the maintenance of the epithelial barrier function and the attenuation of changes in intestinal permeability through effects on tight junction, decreasing paracellular permeability, providing innate defense against pathogens, and enhancing the physical impediment of the mucous layer, – competitive exclusion by the application of probiotic bacteria stabilizing the indigenous microflora, – immunomodulatory capacity, affecting a variety of signaling pathways with modulation of proper immune, inflammatory and allergic responses. The epithelial gut barrier faces important challenges, since its function is to prevent pathogens and harmful elements of the gut lumen from penetrating into the internal environment. Competitive exclusion treatment can increase resistance to pathogen colonization and control intestinal disturbance. The dominance of symbiotic and probiotic bacteria among the gut microbiota favors a tolerogenic immune response. The release of secretory IgA stabilizes tight junctions between cells of the epithelial layer as well as hampers pathogens and symbionts invading deeper layers. The understanding of these vital processes may help to protect the host against infection, prevent chronic inflammation, and maintain mucosal integrity.

9

Drobnoustroje jelitowe fizjologicznym partnerem gospodarza

61%

Binek M., Rzewuska M., Kizerwetter-Swida M., Chrobak-Chmiel D., Gierynska M., Cisek A. A.

Medycyna Weterynaryjna

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2016

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tom 72

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nr 09

The gastrointestinal tract in humans and animals contains a very large number of highly diverse microorganisms. This microbiota plays a major role in the host’s physiology, homeostasis, and well-being. It forms a barrier against infection, helps to develop and mature the immune system, and participates in the extraction of nutrients and energy from food. Various members of microbial community maintain the integrity of the intestinal barrier and promote epithelial repair after injury. The intestinal barrier defenses consist of the mucous layer, antimicrobial peptides, secretory IgA, and the epithelial barrier function by junctional adhesion complex. A healthy host exists in a state of balance with its microorganisms. A disruption of the microbial community increases the host’s susceptibility to infection. Although the immune response is necessary for the host to eliminate the invading pathogen, certain aspects of the host’s response may work to the pathogen’s advantage. Certain components of the microbiota have been shown to drive inflammatory response, which, if uncontrolled, has the potential to induce a pathological response, whereas others enhance or promote antiinflammatory responses. The effector microbial molecules are usually detected via receptor-signaling pathways including Toll-like receptors, NOD-like receptors, and C-type lectin receptors. These pattern-recognition receptors (PRRs) interact with and identify microbe-associated molecular patterns (MAMPs) of both commensal and pathogenic bacteria. PRRs signaling, once thought to exclusively yield pro-inflammatory activation by pathogenic bacteria, is now known to be differentially activated by commensal and probiotic bacteria to induce pathways involved in gut homeostasis, cytoprotection, epithelial cell proliferation, regulation of tight junctions, and antimicrobial peptide secretion. The microbial-epithelial cross-talk is fundamental in appreciating how the developing intestine achieves tolerance to bacteria and how dysregulation of this process may predispose the gut to inflammation and disease.

10

Controlling orthopoxvirus infections - 200 years after Jenner's revolutionary immunization

61%

Niemialtowski M. G., Toka F. N., Malicka E., Gierynska M., De Faundez I. S., Schollenberger A.

Archivum Immunologiae et Therapiae Experimentalis

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1996

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tom 44

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nr 5-6

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