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Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the µ3 opiate receptor subtype: a hormonal role for endogenous morphine

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Stefano G. B., Zhu W., Cadet P., Bilfinger T. V., Mantione K.

Journal of Physiology and Pharmacology

2004

tom 55

nr 1,2

Studies from our laboratory have revealed a novel µ opiate receptor, µ3, which is expressed in both human vascular tissues and leukocytes. The µ3 receptor is selective for opiate alkaloids, insensitive to opioid peptides and is coupled to constitutive nitric oxide (cNO) release. We now identify the µ3 receptor characteristics in mammalian gut tissues. It appears that the various regions of the mouse gut release low levels of NO (0.02 to 4.6 nM ) in a pulsatile manner. We demonstrate that morphine stimulates cNO release (peak level 17 nM) in the mouse stomach, small intestine and large intestine in a naloxone and L-NAME antagonizable manner. Opioid peptides do not exhibit cNO-stimulating capabilities in these tissues. Taken together, we surmise morphine acts as a hormone to limit gut activity via µ3 coupled to NO release since µ opiate receptors are found in the gut and endogenous morphine is not but is found in blood.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Bilfinger T. V.

1 Cadet P.

1 Mantione K.

1 Stefano G. B.

1 Zhu W.

1 2004

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Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the µ3 opiate receptor subtype: a hormonal role for endogenous morphine