The aim of this study was to investigate the accumulation of cadmium (Cd) in the kidneys and its excretion with urine, and possible effect of benzo(a)pyrene (B(a)P) and pyrene on these processes in rats. The studies were conducted on 60 Wistar male rats by short-term (28 d) and subchronic (90 d) experiments. Cadmium was given at doses 0.1 and 0.5 mg/kg. The samples of urine and kidneys were analysed by atomic absorption spectrophotometry. The obtained data showed that Cd in a dose of 0.5 mg/kg significantly increased its renal and urine content; however, the lower dose (0.1 mg/kg) administered during 28 d did not increase Cd urinary excretion levels. This indicates that Cd has a tendency to accumulate in the organism (in kidneys in particular), and when absorbed, is very slowly eliminated from the organism. In short term experiments both doses of Cd increased its accumulation in the kidneys. B(a)P (dose 0.00015 mg/kg) in 28 d and 90 d studies, and pyrene (dose 0.00075 mg/kg) in 90d studies had no effect on the accumulation of Cd in the kidneys and excretion with urine.
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.