Low-energy diets cuid controlled starvation are often treated as therapeutic management having a favourable effect on the health state. The increased catabolism of fat in the tissues leads to evident changes in the levels of various lipid fractions, with initial increase of total cholesterol synthesis followed by its significan fall which continues till the end of the diet. The study wax carried out on volunteers who subjected to careful medical examination before the experiment. The first group were students 7 girls and 5 boys. Group II comprised 21 adult women. The subjects were wished and blood samples for determinations were taken on days 1, 3, 5 and 10 of the experiment. In the serum total cholesterol, HDL-cholesterol and triglycerides were determined. The obtained results showed a positive influence of short-lastin low-calorie diets on the lipid parameters of blood. The serum total lipid level and triglycerides decreased systematically. There was also a significant effect of the diet on the LDL- cholesterol level in the serum. The reduced value of LDL-cholesterol seems to be the most important of the expected effects of the diet.