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1

Effects of beta-endorphin on plasma glucose levels

100%
Akalin P. P., Baspinar N.
Bulletin of the Veterinary Institute in Puławy
|
2010
|
tom 54
|
nr 2
277-282
Healthy, and insulin-deficient (streptozotocin-induced diabetic, STZ) Sprague-Dawley rats were used to investigate the effects of different doses of ß-endorphin (25 and 50 µg/kg) on plasma ß-endorphin, insulin, glucagon, and glucose levels at 15- and 30-min time points. In experimental groups, plasma ß-endorphin levels were higher at the 15-min than at the 30-min time point in healthy rats; however, in STZ-diabetic rats, ß-endorphin levels were lower at 15 min than at 30 min, indicating that intraperitoneal absorption of ß-endorphin differed between healthy and insulin-deficient rats, ß-endorphin did not affect plasma glucose, insulin, or glucagon at either dose in the healthy group. In the insulin-deficient rats, ß-endorphin at 50 µg/kg reduced plasma glucose levels at the 30-min time point compared to the 25 µg/kg dose, without affecting plasma insulin. Moreover, ß-endorphin at 50 µg/kg decreased plasma glucagon levels at the 15-min time point in comparison to the 25 µg/kg dose in insulin-deficient rats. Plasma glucose levels may be reduced in insulin-deficient rats at high ß-endorphin levels regardless of insulin status.
2

Pathological changes in the acute phase of streptozotocin-induced diabetic rats

81%
Ozdermir O., Akalin P. P., Baspinar N., Hatipoglu F.
Bulletin of the Veterinary Institute in Puławy
|
2009
|
tom 53
|
nr 4
This study aimed at investigating the acute phase of pathological changes in streptozotocin-induced diabetic rats with varying glucose levels. Eighteen rats, six control, six D1 group (with glucose level of 200-300 mg/dl), and six D2 group (with glucose level over 300 mg/dl), were used. They were euthanasied on the 14th d after streptozotocin administration. Samples taken from internal organs were examined under a light microscope after routine histopathology processes. The changes in the organs were scored as light, mild and severe. The glomerulus, Bowman's space, and renal corpuscle areas were calculated. There were significant differences between THE diabetic groups and control in terms of degenerative lesions in the pancreas, liver, spleen, and kidneys. It was found that increasing the area of Bowman's space was directly proportional to blood glucose level. There was a significant difference between D1 and D2 in terms of the number of apoptotic cells in the spleen and there was an increase in apoptosis. It was concluded that the increased width of the Bowman's space in the acute phase of type-I diabetes, and the changes observed in the other organs, would be useful for further studies on diabetes.
3

Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

61%
Akalin P. P., Ataseven V. S., Dogan F., Ergun Y., Baspinar N., Ozcan O.
Bulletin of the Veterinary Institute in Puławy
|
2015
|
tom 59
|
nr 3
The aim of this study was to determine the ceruloplasmin (Cp) and vitamin C concentrations, the total antioxidant status (TAS), and selected biochemical parameters in dairy cows spontaneously infected with bovine leukaemia virus (BLV). Of the 27 cows included in the study, 18 animals were seropositive for enzootic bovine leukosis (EBL), whereas nine cows were seronegative and were used as controls. The serum aspartate aminotransferase (AST) (P = 0.003) and Cp concentrations (P = 0.03) decreased (65.17 ± 5.03 and 7.70 ± 0.72 respectively) in BLV-infected cows, as compared to healthy animals (100.67 ± 11.50 and 10.40 ± 0.70 respectively). A slight insignificant increase in alkaline phosphatase activity and unchanged levels of alanine aminotransferase, lactate dehydrogenase, calcium, magnesium, and TAS were demonstrated in EBL cows. As the TAS and vitamin C levels remained unchanged in EBL cows, it may be suggested that ruminants may compensate for the impaired oxidative/antioxidative balance. The results obtained also indicate that BLV may suppress AST and Cp synthesis or secretion in the liver through an unknown mechanism. The mechanism of action of BLV in hepatocytes, especially on AST and Cp, requires further investigation to elucidate the immune suppression caused by oncogenic retroviruses.
4
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Glucose-6-phosphate dehydrogenase, glutathione peroxidase, total glutatione and reduced nicotinamide adenine dinucleotide phosphate in milk cells of subclinical mastitic cows

42%
Akalin P. P., Ergun Y., Baspinar N., Dogruer G., Kucukgul A., Cantekin Z., Isgor M., Saribay M., Koldas E., Bastan A., Salar S., Pehlivanlar S.
Polish Journal of Veterinary Sciences
|
2019
|
tom 22
|
nr 2
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