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1

Regulation of methotrexate polyglutaminate formation in Ehrlich ascites carcinoma cells by endogenous folate pool

100%
Balinska M.
Acta Biochimica Polonica
|
1986
|
tom 33
|
nr 1
2

Metabolizm ametopteryny w komórkach ssaków

100%
Balinska M.
Postępy Biochemii
|
1988
|
tom 34
|
nr 4
3

Rescue effect of exogenous reduced folates on methotrexate polyglutamylation and dihydrofolate reductase activity in L1210 cells

100%
Balinska M.
Acta Biochimica Polonica
|
1988
|
tom 35
|
nr 3
4
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Content available

Wolne rodniki w inwazji pasozytniczej

100%
Balinska M.
Wiadomości Parazytologiczne
|
1992
|
tom 38
|
nr 1-2
17-22
Highly reactive oxygen species potentially represent a powerful effector mechanism against parasites. They are produced during normal cellular metabolism, especially by activated phagocytes. As can be seen from many studies protozoan and helminth parasites appear to have one or more anti-oxidant enzymes able to scavenge or quench the reactive free-radicals, and there is strong evidence that such enzymes may play crucial role in protecting against host response. Presented there review illustrates that methods to block anti-oxidant protection of parasites may be new field in the search for improved ways to inhibit parasitic survival.
5

Synergistic cell growth inhibition by combination of antifolates

100%
Balinska M.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 3
6

Rola homocysteiny w procesie rozwoju zmian miazdzycowych na poziomie komorkowym.

63%
Brzezinska A., Balinska M.
Postępy Biologii Komórki
|
2000
|
tom 27
|
nr 1
81-96
7

Rola jonow wapnia w komorce nowotworowej

63%
Balinska M., Janiszewska D.
Kosmos
|
1997
|
tom 46
|
nr 4
537-540
8

Methionine synthase assay based on coupling whit thymidylate synthase reaction

63%
Rode W., Balinska M.
Acta Biochimica Polonica
|
1985
|
tom 32
|
nr 2
9

Regulacja metabolizmu folianowego u grzybow: Aspergillus nidulans jako model badawczy

63%
Paszewski A., Balinska M.
Postępy Biochemii
|
1996
|
tom 42
|
nr 2
129-132
10

Nowotwory a starzenie.

51%
Balinska M., Brzezinska A., Winska P.
Postępy Biologii Komórki. Suplement
|
2000
|
tom 15
45-55
11

Role of extracellular calcium in the induction of pinocytosis in Amoeba proteus by Na and K ions

51%
Klopocka W., Balinska M., Kolodziejczyk J.
Acta Protozoologica
|
2000
|
tom 39
|
nr 2
12

Cellular aspects of folate and antifolate membrane transport

51%
Brzezinska A., Winska P., Balinska M.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 3
Folates one carbon carriers take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
13

The effects of combined antifolates on inhibition of growth of murine leukemia cells cultured in vitro

45%
Balinska M., Szablewska I., Janiszewska D., Bartuzi K., Pawelczak K.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 4
The synergistic effect of trimetrexate (TMTX) and sulphonamide derivatives of quinazoline on the cultured 5178Y murine leukemia cells was examined. On exposure to the slightly inhibitory concentrations of TMTX (0.1 nM) in combination with 2-desamino-2-methyl-10-propargyl-5,8-dideaza-pteroyl-sulphoglyc ine (DMPDDSF) (0.02 microM) a synergistic inhibitory effect of the antifolates on cell growth was observed. These two drugs in the same combination caused also synergistic inhibition of de novo synthesis of thymidylate in intact cells as measured by tritium release from [5-(3)H]deoxyuridylate. This was accompanied by a marked reduction in intracellular concentration of 5,10-methylenetetrahydro-pteroyl-polyglutamate (5,10CH2H4PteGlu(n)) (0.2 microM) and dihydropteroyl-polyglutamate (0.12 microM). In these conditions de novo biosynthesis of purine was decreased by 50%. These observations show that growth inhibition by combined antifolates is mediated by intracellular depletion of the substrate of thymidylate synthase -- 5,10CH2H4PteGlu(n). The results obtained strongly suggest that under certain conditions inhibition of thymidylate synthesis by DMPDDSF is intensified by prior application of TMTX -- an inhibitor of dihydrofolate reductase.
14

Synergistic effect of 5-fluorodeoxyuridine and quinazoline antifolates on murine leukemia self-cultured in vitro

45%
Balinska M., Szablewska I., Janiszewska D., Brzezinska A., Pawelczak K.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 4
The effect of thymidylate synthase inhibitors, fluorodeoxyuridine (FdUrd) and its two sulphonamide derivatives was examined in the culture of murine leukemia cells -- 5178Y (parental subline) and its fluorodeoxyuridine resistant subline 5178Y/F. A synergistic effect of the antimetabolites on cell survival was observed on exposure of the culture of either line to a slightly inhibitory concentration of FdUrd (1 nM) in combination with 2-desamino-2-methyl-10-propargyl-5,8-dideaza-pteroylsulphogluta mate or 2-desamino-2-methyl-10-propargyl-5,8-dideaza-pteroylsulphoglyci ne. This effect was accompanied by a marked reduction, in both cell lines of intracellular concentration of 5,10-methylenetetrahydro-pteroyl-polyglutamate, although its concentration in the resistant subline was 3 times as high as in the parental line. The inhibitory effect of combined drugs on the cellular pool of folates in 5178Y line depended also on the sequence of drug addition, whereas in the FdUrd resistant line this sequence was without any effect. The results obtained strongly suggest that under certain conditions inhibition of thymidylate synthesis by antifolates is intensified by a prior use of FdUrd.
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