Wyniki wyszukiwania

1

Toksyczność pyretroidów w świetle badań lat ostatnich

100%

Zielinski W., Ziemkiewicz P.

Bromatologia i Chemia Toksykologiczna

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1991

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tom 24

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nr 3-4

2

Lack of induction of potential preneoplastic lesions by captan, captafol and daminozide in the colons of rats

81%

Rahden-Staron I., Czeczot H., Szumilo M., Ziemkiewicz P.

Acta Poloniae Toxicologica

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1997

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tom 05

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nr 2

159-166

3

The effects of captan and captafol on different bacterial strains and on c-mitosis in V79 chinese hamster fibroblasts

80%

Rahden-Staron I., Szumilo M., Ziemkiewicz P.

Acta Biochimica Polonica

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1994

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tom 41

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nr 1

The mutagenic activity of captan and captafol was tested using Ames stzaiiis and strains showing an SOS response. Captafol was mutagenic in S. typhimurium strain TA102 (uvr+) and captan in strain TA104 (uvrB). Both captan and captafol elicit damages in DNA recognized by correndonuclease U, as shown by the repair teat, and induced the SOS repair system in E. coli PQ37 (uvrA) strain. Only captafol induced the SOS system in PQ35 (uvr+). The lack of induction of p-galactesidaac at nonpermissive temperature in E. coli MD332 (dnaCs uvrA) strain showed that neither chemical was able to produce DNA breaks. In V79 Chinese hamster fibroblasts higher induction of c-mitosis by captafol than by captan (22% and 15% over th* control, respectively) was accompanied by a higher decrease in nonprotein sulfhydryl groups, mainly GSH (41% and 77%, respectively). The content of protein sulfhydryl groups was decreased by either fungicide to a similar extent.

4

Daminozide - lack of the genotoxic activity in the short-term bacterial test

80%

Rahden-Staron I., Szumilo M., Ziemkiewicz P., Szymczyk-Wasiluk T.

Roczniki Państwowego Zakładu Higieny

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1997

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tom 48

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nr 2

In the recent paper genotoxic effects of daminozide and its metabolites were tested. Evaluation of the mutagenic effect of daminozide was by: (i) the Salmonella/mammalian microsome Ames test with S.typhimurium TA97, TA98, TA100 and TA102. (ii) E. coli PQ37 strain to reveal an induction of the SOS response, (iii) S. typhimurium TA1538 (uvrB) and TA1978 (uvr+) to detect the chemicals bound covalently to DNA (repair test). Daminozide was not mutagenic in any of the S.typhimurium strains and did not induce damages in DNA recognized by correndonuclease II, as shown by the repair test. Only metabolites of daminozide induced the SOS system.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Acta Poloniae Toxicologica

1 Bromatologia i Chemia Toksykologiczna

1 Roczniki Państwowego Zakładu Higieny

4 Ziemkiewicz P.

3 Rahden-Staron I.

3 Szumilo M.

1 Czeczot H.

1 Szymczyk-Wasiluk T.

1 Zielinski W.

2 1997

1 1994

1 1991

Toksyczność pyretroidów w świetle badań lat ostatnich

Lack of induction of potential preneoplastic lesions by captan, captafol and daminozide in the colons of rats

The effects of captan and captafol on different bacterial strains and on c-mitosis in V79 chinese hamster fibroblasts

Daminozide - lack of the genotoxic activity in the short-term bacterial test