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Scleractinian skeleton is composed of mineral and organic phases. Using staining techniques (acridine orange dye) Johnston's (1980) pioneering observations of intraskeletal organic envelopes in Pocillopora damicornis coralla can be extended to two other coral reef genera i.e., Acropora and Favia. The concept of biologically mediated growth of coral skeleton stands in opposition to the purely mineralogic concept of fiber growth of Bryan and Hill (1941) widely applied until recently in geological and paleontological literature. Presence of active mineralizing organic components within the skeleton explains various patterns of microstructural organization more accurately than the mineralogic concept of 'crystal growth competition' of Barnes (1970) alone. Biochemical degradation of intraskeletal organic matrices is considered to be involved in the initial diagenesis of coral skeleton, and may explain selective silicification of the late Cretaceous Coelosmilia sp. from Poland.
A reticulocytosis induced by injections of phenylhydrazine to white mice enhanced the gametocyte production of Plasmodium berghei. Gametocytogenesis of P. yoelii and P. vinckei petteri were not affected by phenylhydrazine treatment.
Plasmodium chabaudi, a rodent malaria parasite with a synchronous asexual cycle in the blood, depending on the host’s circadian rhythm, was desynchronized by modifying its normal timing: blood taken from a donor mouse in the morning was kept 8 h at +4°C and inoculated in the evening into naive mice. When the infection had become asynchronous (from day 4 to day 7) mice were treated with a single dose of chloroquine. The efficacy of chloroquine was lower in mice with an asynchronous infection than in the control mice with a normally synchronous infection.
Bistramide D and K were extracted from a New Caledonian marine colonial ascidian Lissoclinum bistratum and tested against Plasmodium berghei and P. vinckei petteri in mice. Bistramide D was able to reduce parasitaemia by almost 50% in P. berghei infected mice, but the ID₅₀ (>5 mg/kg) was very close to the LD₅₀ (8 mg/kg). In the same assay, bistramide K was less active than bistramide D. The mid-term trophozoite and the old trophozoite were shown to be the stages most sensitive to bistramide D in P. vinckei petteri infected mice. Therefore, bistramides are interesting experimental tools but do not present a major interest as potential antimalarial drugs.
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