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1
Content available remote

Pathophysiology of drug-induced peripheral neuropathy in patients with multiple myeloma

100%
Luczkowska K., Litwinska Z., Paczkowska E., Machalinski B.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 2
2

Rola komorek macierzystych w procesie endogennej regeneracji osrodkowego ukladu nerwowego na przykladzie wybranych schorzen naczyniowych

100%
Machalinski B., Machalinska A., Paczkowska E.
Postępy Biologii Komórki
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2010
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tom 37
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nr 1
241-252
3

The effects of Propiscin on the cardiac rate of isolated heart of common carp, Cyprinus carpio L.

100%
Hajek G. J., Klyszejko B., Dziaman R., Paczkowska E.
Acta Ichthyologica et Piscatoria
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2004
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tom 34
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nr 2
Background. The use of anaesthetics in aquaculture requires conducting specific physiological studies of its effect on fish. The objective of this study was to evaluate the direct effect of Propiscin (IRS Olsztyn, Poland) on the rate of isolated heart of common carp. Materials and Methods. The activity of isolated, perfused heart was recorded using an electrocardiograph. Propiscin was applied at concentrations of 2, 10, and 100 mlּl-1 of perfusion medium. Results. The study revealed a stimulating effect of Propiscin applied at a concentration of 10 mlּl-1, a depressing effect being recorded at a concentration of 100 mlּl-1. No effects were observed at the Propiscin concentration of 2 mlּl-1. Conclusion. It has been concluded that bradycardia accompanying the anaesthesia evoked by Propiscin at concentrations of 1 and 2 mlּl-1 of water is not a result of direct effect of Propiscin on the carp′s heart.
4

Mobilization of human hematopoietic stem-progenitor-enriched CD34plus cells into peripheral blood during stress related to ischemic stroke

100%
Machalinski B., Paczkowska E., Koziarska D., Ratajczak M. Z.
Folia Histochemica et Cytobiologica
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2006
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tom 44
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nr 2
5

Evidence that functional neural tissue-committed stem cells (NTCSC) reside in the human bone marrow and are mobilized into peripheral blood after stroke

88%
Raca R., Kucia M., Paczkowska E., Machalinski B., Ratajczak M. Z.
Acta Neurobiologiae Experimentalis
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2006
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tom 66
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nr 4
6
Content available remote

Stem cells for neural regeneration - a potential application of very small embryonic-like stem cells

76%
Ratajczak J., Zuba-Surma E., Paczkowska E., Kucia M., Nowacki P., Ratajczak M. Z.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 1
The goal of regenerative medicine is to ameliorate irreversible destruction of brain tissue by harnessing the power of stem cells in the process of neurogenesis. Several types of stem cells, including mesenchymal stem cells, hematopoietic stem cells, as well as neural cells differentiated from embryonic stem cell lines, have been proposed as potential therapeutic vehicles. In this review paper we will discuss a perspective of stem cell therapies for neurological disorders with special emphasis on potential application of cells isolated from adult tissues. In support of this our group found that murine bone marrow contains a mobile population of Oct-4+CXCR4+SSEA-1+Sca-1+lin–CD45– very small embryonic-like stem cells (VSELs) that are mobilized into peripheral blood in a murine stroke model. The number of these cells in circulation increases also after pharmacological mobilization by administration of granulocyte colony stimulating factor (G-CSF). Recently we found that VSELs are present in various non-hematopoietic adult organs and, interestingly, our data indicate that the brain contains a high number of cells that display the VSEL phenotype. Based on our published data both in human and mice we postulate that VSELs are a mobile population of epiblast/germ line-derived stem cells and play an important role as an organ-residing reserve population of pluripotent stem cells that give rise to stem cells committed to particular organs and tissues - including neural tissue. In conclusion human VSELs could be potentially harnessed in regenerative medicine as a source of stem cells for neurogenesis.
7
Content available remote

Expression of neurotrophins and their receptors in human CD34plus bone marrow cells

64%
Paczkowska E., Piecyk K., Luczkowska K., Kotowski M., Roginska D., Pius-Sadowska E., Oronowicz K., Ostrowski M., Machalinski B.
Journal of Physiology and Pharmacology
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2016
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tom 67
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nr 1
8

The influence of BDNF on human umbilical cord blood stem/progenitor cells: Implications for stem cell-based therapy of neurodegenerative disorders

64%
Paczkowska E., Luczkowska K., Piecyk K., Roginska D., Pius-Sadowska E., Ustianowski P., Cesarska E., Dolegowska B., Celewicz Z., Machalinski B.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
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nr 2
Umbilical cord blood (UCB)-derived stem/progenitor cells (SPCs) have demonstrated the potential to improve neurologic function in different experimental models. SPCs can survive after transplantation in the neural microenvironment and induce neuroprotection, endogenous neurogenesis by secreting a broad repertoire of trophic and immunomodulatory cytokines. In this study, the influence of brain-derived neurotrophic factor (BDNF) pre-treatment was comprehensively evaluated in a UCB-derived lineage-negative (Lin-) SPC population. UCB-derived Lin- cells were evaluated with respect to the expression of i) neuronal markers using immunofluorescence staining and ii) specific (TrkB) receptors for BDNF using flow cytometry. Next, after BDNF pre-treatment, Lin- cells were extensively assessed with respect to apoptosis using Western blotting and proliferation via BrdU incorporation. Furthermore, NT-3 expression levels in Lin- cells using RQ PCR and antioxidative enzyme activities were assessed. We demonstrated neuronal markers as well as TrkB expression in Lin- cells and the activation of the TrkB receptor by BDNF. BDNF pre-treatment diminished apoptosis in Lin- cells and influenced the proliferation of these cells. We observed significant changes in antioxidants as well as in the increased expression of NT-3 in Lin- cells following BDNF exposure. Complex global miRNA and mRNA profiling analyses using microarray technology and GSEA revealed the differential regulation of genes involved in the proliferation, gene expression, biosynthetic processes, translation, and protein targeting. Our results support the hypothesis that pre-treatment of stem/progenitor cells could be beneficial and may be used as an auxiliary strategy for improving the properties of SPCs.
9

The effect of stem cell mobilisation with granulocyte colony-stimulating factor on the morphology of the haematopoietic organs in mice

64%
Barcew K., Paczkowska E., Dabkowska E., Baskiewicz-Masiuk M., Marchlewicz M., Domanski L., Sagan L., Wiszniewska B., Machalinski B.
Folia Morphologica
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2007
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tom 66
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nr 1
The cellular mobilisation of mice with granulocyte colony-stimulating factor (G-CSF) results in an egress of haematopoietic stem/progenitor cells from the bone marrow and an increase in their level in the peripheral blood. While the mobilisation process with different agents is widely studied, little is known about the morphology of the murine haematopoietic organs during the mobilisation. The purpose of this study was to examine the morphology of the bone marrow, spleen and liver in mice mobilised with G-CSF. To address this issue mice were injected subcutaneously with G-CSF for 6 consecutive days. Morphological analysis revealed an increase in the number of mature neutrophils close to the wall of sinusoids in the bone marrow as well as hypertrophy of the red pulp in the spleen. At the same time no morphological changes were noticed in the livers of G-CSF-mobilised mice. In conclusion, G-CSF induces discrete ultrastructural changes in the bone marrow, which intensify the transendothelial traverse of haematopoietic stem and progenitor cells from it. The changes in the spleen are related to repopulation of this organ by mobilised early haematopoietic cells circulating in the peripheral blood. We also noticed that the process of migration of haematopoietic cells from the bone marrow into the peripheral blood began on day 2 and was most pronounced on day 4 after stimulation with G-CSF.
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