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Association of ACE DD genotype with Hypertension among the tribal populations of South India

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Paramasivam R., Nandakumar R., Arumugam D., Krishnan P.

International Letters of Natural Sciences

2016

tom 52

The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0 .705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

Ograniczanie wyników

1 International Letters of Natural Sciences

1 Arumugam D.

1 Krishnan P.

1 Nandakumar R.

1 Paramasivam R.

1 2016

Wyniki wyszukiwania

Association of ACE DD genotype with Hypertension among the tribal populations of South India