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Ischemic brain damage along the visual pathways frequently manifest with visual field defects. Most occipital lobe infarcts lead to homonymous hemianopia. Additionally, cognitive problems are often present. Visual field defects caused by occipital lobe infarction are often permanent causing long-term disability in vision and in daily life activities. Patients lose environmental control, give up their activities, have difficulties in reading and watching, lose their driving licence, are prone to accidents, and working-age patients often have to give up their work. Approximately 20–30% of ischemic stroke patients have some degree of visual field defect. Only half of these patients recover, most recovery occurring within 3 months. IV thrombolysis is the only approved acute treatment in ischemic stroke, but most patients having an occipital infarction score low on neurologic scores and do not usually receive thrombolysis. We have recently described that thrombolysis was safe in these patients and was associated with high rates of improvement. Future efforts must concentrate on disseminating thrombolytic therapy in this patient group and developing effective rehabilitation methods for reducing the burden of the disease, but current treatment options are limited.
Non-invasive brain stimulation is a promising tool in treatment of visual impairment. The aim of the ‘Restoration of Vision after Stroke’ (REVIS) network is to determine if non-invasive current stimulation may also have a positive impact on vision restoration in patients with post-chiasmatic visual pathway lesions. In particular, the potential of non-invasive current stimulation in ameliorating vision impairment following stroke is the key issue addressed by the REVIS study group. Within the REVIS network a number of small sample, randomized, controlled, clinical studies including patients with post-chiasmatic lesions due to monohemispheric, ischemic or hemorrhagic stroke were initiated by clinical partners from Germany, Italy and Finland. The network also includes a basic neuroscience project that studies neuronal network reorganization in the cat visual system after stroke (Poland). Beyond the European network, a collaboration with the Institute of Automation at the Chinese Academy of Science was established. This contribution presents the overall aims of the network activity, the rational of the clinical endpoint selection and preliminary findings.
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