The aim of the study was to investigate the effect of 10-day treatment (i.p.) with Padma 28 on the levels of a-fetoprotein and ß2-microglobulin and the activities of aminotransferases ALT and AST in the serum of cadmium-poisoned rats (dose of 0.36 mg/kg i.p.). It was found that acute intoxication with cadmium chloride significantly enhanced AFP and ß2-microglobulin levels and did not affect the activity of ALT and AST in the serum of rats in comparison with the control group. Padma 28 administrated for 10-days only in the dose of 1 mg/kg significantly decreased AFP and in the doses of 0.1 and 1 mg/kg increased ß2-microglobulin levels while it did not affect the activity of ALT and AST in the serum of cadmium-poisoned rats. 10-day treatment with Padma 28 has been found to increase nephrotoxic effects of cadmium in rats acutely intoxicated with this metal.
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