Wyniki wyszukiwania

1

The interaction between paroxetine and some cytokines in the animal model of depression

100%

Manikowska K., Mikolajczak P. L., Bobkiewicz-Kozlowska T., Modzelewska J.

Acta Neurobiologiae Experimentalis

|

2013

|

tom 73

|

nr Suppl.1

Knowledge about the role of cytokines in the action antidepressant drugs is still insufficient. The aim of the this study was to evaluate the effect of paroxetine (PAR) on the levels of tumor necrosis factor alpha (TNFα), and interleukin-10 (IL-10) in the blood of rats in an experimental model of depression. Male Wistar rats were subjected to chronic mild stress (CMS) for 6 weeks. Following the development of anhedonia, the stressed and control rats (non-stressed animals) were treated with PAR (12.5 mg/kg b.w., p.o. 1× daily) for three weeks. On the last day of the experiment, an acute lipopolysaccharide (LPS, 100 µg/kg b.w., i.p.) was injected to PAR or vehicle-treated rats and TNFα and IL-10 levels were assayed using ELISA methods. In stressed animals the level of TNFα was found to be significantly higher compared to non-stressed animals. PAR resulted in significant decrease in TNFα level and simultaneously the increase of IL-10 in the stressed animals. In conclusion, PAR induced normalisation of the TNFα level increased by stress and LPS and elevation of IL-10 level in animal model of depression what confirms the hypothesis that level of cytokines can be modulated by antidepressant drugs.

2

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Borage (Borago officinalis L.) - a valuable medicinal plant used in herbal medicine

100%

Pieszak M., Mikolajczak P. L., Manikowska K.

Herba Polonica

|

2012

|

tom 58

|

nr 4

In Europe, the use of herbs in the treatment of various ailments had been natural for centuries. Nowadays, phytotherapy is a way to support typical pharmacotherapy of many diseases. Borage (Borago officinalis L.) is one out of more than 20 000 plants of therapeutic properties. The results of some studies indicate that Borago officinalis L. is commonly used adjunctively in disorders of the respiratory system, urinary tract, arthritis and skin problems. Biologically active compounds found in borage oil are used as additives in the treatment of atherosclerosis, as well as in the regulation of certain metabolic processes.

3

Kosmonauci na gape

100%

Manikowski P., Manikowska K.

Wiedza i Życie

|

2002

|

nr 02

14-15

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Herba Polonica

1 Wiedza i Życie

3 Manikowska K.

2 Mikolajczak P. L.

1 Bobkiewicz-Kozlowska T.

1 Manikowski P.

1 Modzelewska J.

1 Pieszak M.

1 2013

1 2012

1 2002

The interaction between paroxetine and some cytokines in the animal model of depression

Borage (Borago officinalis L.) - a valuable medicinal plant used in herbal medicine

Kosmonauci na gape