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1

Sclerosing stromal tumour - the description of three cases of the ovary rare benign neoplasm

100%
Korobowicz E., Wronecki L., Siezieniewska-Skowronska Z.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
2

Carcinosarcoma of the lung: an analysis of 8 operated cases

100%
Korobowicz E., Zdunek M., Szumilo J., Furmanik F.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
3

Multifocal fibromatosis: a case report

100%
Korobowicz E., Radwanska-Konarzewska U., Szumilo J.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
4

Experimental models of cyclosporine A nephrotoxicity

88%
Korolczuk A., Maciejewski M., Czechowska G., Celinski K., Korobowicz E.
Bulletin of the Veterinary Institute in Puławy
|
2010
|
tom 54
|
nr 1
59-62
The aim of this study was to compare the most commonly-used experimental models and to assess the microscopic renal changes in different models of cyclosporine A (CsA) nephrotoxicity. Wistar male rats were divided into five groups, eight animals in each. CsA was given in doses of 15 mg/kg, 25 mg/kg, and 100 mg/kg, respectively. The blood was collected for creatinine, urea, and uric acid levels analysis in the serum and the kidneys were sampled for microscopic examination on the 11th and 29th d of the experiment. CsA induced nephrotoxicity was characterised by increased serum levels of creatinine, urea, and uric acid. Microscopic features of CsA nephrotoxicity in all CsA experimental groups were observed. We would recommend the use of low doses of CsA for approximately 28 d as the most relevant experimental procedure for achieving the features of chronic CsA nephrotoxicity.
5

Immunological system status and the appearance of respiratory system disturbances in thymectomized patients

88%
Krawczyk P., Adamczyk-Korbel M., Kieszko R., Korobowicz E., Milanowski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
tom 55
|
nr 1
6

The coexistence of cystic nephroma and renal cortical adenoma

88%
Skomra D., Korobowicz E., Bar K., Szumilo J., Wronecki L.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
7

Prevalence of Chlamydia trachomatis in cervical and vulvar carcinoma of the Lublin Region patients

88%
Kwasniewska A., Skoczynski M., Korobowicz E., Semczuk M., Gozdzicka-Jozefiak A.
Bulletin of the Veterinary Institute in Puławy
|
2007
|
tom 51
|
nr 3
The aim of the study was to evaluate frequency of occurrence of Chlamydia trachomatis infection in samples of cervical and vulvar cancer in patients of the Lublin Region. The study was performed on paraffin sections prepared from the specimens of cervical cancer obtained from 570 patients and of vulvar cancer from 46 patients. We identified archival diagnostic phase tissue specimens. The control material to that obtained from patients with cervical cancer consisted of normal cervical tissues. The control material to that obtained from patients with vulvar cancer were fragments of normal epithelial tissue collected from the same paraffin blocks containing material from the margin of surgical section during vulvectomy. In order to identify Chlamydia trachomatis, DNA isolated from archival material was analysed and PCR was performed using starters complementary to Chlamydia trachomatis. Statistically significantly higher frequency of the occurrence of Chlamydia trachomatis was observed in sections from patients with invasive cervical cancer compared to control group. In the analysed material, the frequency of cases of vulvar cancer with co-occurrence of Chlamydia trachomatis infection was not statistically significant. Chlamydia trachomatis may not be directly involved in the oncogenic processes but may enhance the possibility of oncogenesis or infect cancer tissues opportunistically.
8

Detection of Epstein-Barr virus and immunohistochemical studies in cases of undifferentiated carcinoma with lymphoid stroma of the parotid gland and the uterine cervix

88%
Jarosz B., Kocki J., Korobowicz E., Wojcierowski J., Staroslawska E.
Bulletin of the Veterinary Institute in Puławy. Supplement
|
2002
9

Immunohistochemical study of retinoblastoma protein expression in laryngeal squamous cell carcinoma according to low and high overexpression

76%
Morshed K., Korobowicz E., Skomra D., Szymanski M., Polz-Dacewicz M., Golabek W., Smolen A.
Bulletin of the Veterinary Institute in Puławy
|
2008
|
tom 52
|
nr 4
The aim of this study was to determine the possible relevance of the retinoblastoma protein (pRb) expression in laryngeal cancer as a prognostic criterion and to analyse the correlation between the expression and clinical and pathological features vs. survival rates. The immunohistochemical staining was used to detect the expression of pRb in 130 samples of laryngeal cancer and in 22 specimens of laryngeal nodules. pRb nuclear expression was detected in 90 (69%) out of 130 patients with laryngeal squamous cell carcinoma (LSCC), and in three (13.6%) samples of laryngeal nodules. pRb expression correlated with high tumour stage. Patients with high expression of pRb (≥ 50%) had worse survival rates than patients with low expression (< 50%) in 3- and 5-year overall survival observation. A multivariate analysis of survival showed that pRb expression was not an independent prognostic factor in laryngeal cancer. The expression of pRb in LSCC is connected with higher tumour stage.
10

Aktywnosc dehydrogenazy mleczanowej ludzkich erytrocytow w obecnosci wybranych inhibitorow dehydrogenazy alkoholowej

76%
Dudka J., Burdan F., Madej B., Tokarska E., Klepacz R., Korobowicz E.
Roczniki Państwowego Zakładu Higieny
|
2004
|
tom 55
|
nr 3
229-234
W pracy oceniono wpływ cymetydyny, EDTA, 4-metylopirazolu oraz etanolu i metanolu na aktywność dehydrogenazy mleczanowej. Badania przeprowadzono in vitro z enzymem otrzymanym z erytrocytów ludzkich.
11

Zakazenie Chlamydophila pneumoniae u chorych z tetniakiem aorty brzusznej - aspekt immunologiczny i konsekwencje kliniczne

76%
Mazur E., Niedzwiadek J., Wolski A., Korobowicz E., Michalak J., Koziol-Montewka M.
Medycyna Weterynaryjna
|
2003
|
tom 59
|
nr 12
1103-1110
12

Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma

76%
Szumilo J., Burdan F., Zinkiewicz K., Dudka J., Klepacz R., Dabrowski A., Korobowicz E.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 4
13

Wplyw inhibitorow ukladu renina-angiotensyna na obraz morfologiczny trzustki w eksperymentalnym przewleklym zapaleniu tego narzadu

76%
Madro A., Czechowska G., Korolczuk A., Celinski K., Slomka M., Prozorow-Krol B., Korobowicz E.
Medycyna Weterynaryjna
|
2008
|
tom 64
|
nr 01
97-100
Chronic pancreatitis (CP) is a progressive disease, in which the exocrine function of the gland is gradually lost and fibrosis develops due to repeated episodes of acute pancreatitis. The detection of the renin-angiotensin system (RAS) brings us closer to understanding the pathogenesis of CP. It has been observed that the use of RAS inhibitors reduces hepatic fibrosis. The aim of the study was to examine the effects of RAS inhibitors on fibrotic processes in the course of experimental chronic pancreatitis induced by dibutyltin dichloride (DD). Chronic pancreatitis was induced by administering dibutyltin dichloride to the femoral vein and, simultaneously, captopril, losartan and enalapril which were administered intraperitoneally. The rats were decapitated after 60 days and pancreas tissue was collected for histopathology examination. No pathological changes were observed in the control group. Rats treated by dibutyltin dichloride displayed features of focal inflammatory infiltration, ductal lumen dilatation, fibrosis in the periductal spaces and slight interstitial fibrosis. Animals treated by RAS inhibitor displayed less severe inflammatory changes and fibrosis - particularly those rats treated by enalapril. The findings suggest that enalapril most effectively inhibits inflammatory changes and fibrosis.
14

Expression of p21 and bcl-2 proteins and p53 gene in etoposid and cisplatin induced chemotherapy in surgically resected stage IIIA non-small cell lung cancer

76%
Mandziuk S., Dudzisz-Sledz M., Rybacka-Chabros B., Jakubowicz-Klecha A., Korobowicz E., Milanowski J., Wojcierowski J.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
15
Content available remote

RAS inhibitors decrease apoptosis of acinar cells and increase elimination of pancreatic stellate cells after in the course of experimental chronic pancreatitis induced by dibutyltin dichloride

76%
Madro A., Korolczuk A., Czechowska G., Celinski K., Slomka M., Prozorow-Krol B., Korobowicz E.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 2
Chronic pancreatitis (CP) is a progressive disease, in which the exocrine function of the gland is gradually lost and fibrosis develops due to repeated episodes of acute pancreatitis. The aim of the study was to investigate the effects of RAS inhibitors on the apoptosis of acinar cells and pancreatic stellate cells (PSCs) elimination in experimental CP induced by dibutyltin dichloride (DBTC). CP was induced by administration of DBTC to the femoral vein. Simultaneously captopril, losartan, enalapril and lisinopril were administered intraperitoneally. The rats were decapitated after 60 days and tissue of pancreas was collected. In rats treated by DBTC the features of inflammatory infiltration, ductal lumen dilatation, fibrosis were found. Strong reactivity with capsase2L and clusterin-ß antibodies was observed in areas of fibrosis. In animals treated with RAS inhibitors inflammatory changes and fibrosis were less severe. In groups of rats treated with DBTC and RAS inhibitors immunoreactivity of capsase2L and clusterin-ß was weak. Positive immunostaining against smooth muscle actine and desmin was observed in the elongated cells (PSC-s). This reaction was weak in groups of rat treated with DBTC and RAS inhibitors. Treatment of CP rats with RAS inhibitors alleviate apoptosis of pancreatic acinar cells and induces PSCs elimination.
16

Co-expression of Epstein-Barr virus latent membrane protein 1, BCL-2, BCL-XL, P21CIP1 and P53 genes in human lymhoepithelial carcinoma

64%
Kocki J., Jarosz B., Constantinou M., Korszen-Pilecka I., Pilecki M., Antosz H., Staroslawska E., Korobowicz E., Kaluzewski B., Wojcierowski J.
Bulletin of the Veterinary Institute in Puławy. Supplement
|
2002
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