Wyniki wyszukiwania

1

Regulacja syntezy czasteczki fibrynogenu

100%

Pluskota E., Cierniewski C. S.

Postępy Biochemii

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1995

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tom 41

|

nr 2

115-120

2

Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group

51%

Misiura K., Wojcik M., Krakowiak A., Koziolkiewicz M., Pawlowska Z., Pluskota E., Cierniewski C. S., Stec W. J.

Acta Biochimica Polonica

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1998

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tom 45

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nr 1

Dimethoxytritylphosphono-oligonucleotide conjugates have been prepared. They are totally resistant to nucleases present in human serum and do not affect cleavage of a complementary oligoribonucleotide by RNase H. Conjugates possessing a phosphate backbone gave better antisense inhibition of expression of plasminogen activator inhibitor type-1 within endothelial cells as compared with unconjugated oligonucleotides.

3

Antisense oligonucleotides to PAI-1 mRNA as potential agents for therapeutic intervention in cardiovascular diseases

51%

Cierniewski C. S., Pawlowska Z., Pluskota E., Stasiak M., Kobylanska A., Misiura K., Maciaszek A., Koziolkiewicz M., Stec W. J.

Biotechnologia

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1996

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nr 4

4

Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5' -end lipophilic modification

42%

Kobylanska A., Pluskota E., Swiatkowska M., Wojcik M., Cierniewska-Cieslak A., Krakowiak A., Boczkowska M., Pawlowska Z., Okruszek A., Koziolkiewicz M., Cierniewski C. S., Stec W. J.

Acta Biochimica Polonica

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1999

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tom 46

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nr 3

A series of conjugates containing residues of lipophilic alcohols covalently bound to 5'-end of oligodeoxyribonucleotides targeted against human plasminogen activator inhibitor (PAI-1) mRNA was synthesized via the oxathiaphospholane approach. The highest anti-PAI-1 activity in EA.hy 926 endothelial cell cultures was found for conjugates containing menthyl or heptadecanyl groups linked with an oligonucleotide complementary to a segment of human PAI-1 mRNA. The phosphodiester antisense oligonucleotides, which otherwise exhibit only limited anti-PAI-1 activity, were found to be more active than phosphorothioate oligonucleotides when conjugated to lipophilic alcohol residues. For menthyl conjugates an evidence of antisense mechanism of inhibition was found.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Biotechnologia

1 Postępy Biochemii

4 Cierniewski C. S.

4 Pluskota E.

3 Koziolkiewicz M.

3 Pawlowska Z.

3 Stec W. J.

2 Kobylanska A.

2 Krakowiak A.

2 Misiura K.

2 Wojcik M.

1 Boczkowska M.

1 Cierniewska-Cieslak A.

1 Maciaszek A.

1 Okruszek A.

1 Stasiak M.

1 Swiatkowska M.

1 1999

1 1998

1 1996

1 1995

Regulacja syntezy czasteczki fibrynogenu

Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group

Antisense oligonucleotides to PAI-1 mRNA as potential agents for therapeutic intervention in cardiovascular diseases

Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5' -end lipophilic modification