The work presents an initial information about degree of toxicological risk for chickens treated with sodium salinomycin in the Slovak anticoccidial (Synvertas plv. ad us. vet., Biotika, Slovenská L’upča, Slovak Republic), under conditions of acute intoxication. Median lethal dose (LD₅₀) of sodium salinomycin in Synvertas plv. ad us. vet. preparation (Biotika) has been determined in 2 and 4-week-old chickens, both sexes, meat type Ross breed. Clinical symptoms of poisoning and patho-morphological changes in dead chickens have been observed as well. Development of clinical symptomatology of poisoning and decrease in intoxication symptoms in 4-weeks-old chickens has been observed even after a single administration of sodium salinomycin in sublethal doses : 20, 30, 40, 50, and 70 mg.kg⁻¹ of body weight (b. w.). LD₅₀ of sodium salinomycin in the objective preparation was calculated on double dose by the interpolation method according to Roth et al. (21) on mortality within 24 h. LD₅₀ value of sodium salinomycin in Synvertas preparation was determined at 102 mg.kg⁻¹ of b. w. (1020 mg of preparation) in 2-week-old chickens and at 106 mg.kg⁻¹ of b. w. (1060 mg of preparation) in 4-week-old ones. From clinical signs of intoxication after lethal doses of 100 and 120 mg of sodium salinomycin per kg⁻¹ of b. w. (1000 and 1200 mg of preparation), the following signs were in the foreground: ataxia, lying on the side or in sternal position with forward stretched neck and legs stretched backward, dyspnoea, cyanosis, sharp CNS inhibition, loss of acoustic and touch reactions. Death occured within 12 h and was accompanied by mild myoclonus symptoms (3-4) with backward stretched limbs. Hyperaemia of the liver, pancreas, spleen and kidneys, anaemia of GIT mucosa, diffuse acute bronchopneumonia, in one chicken lung oedema, slight anaemia of thoracic musculature, slight banding of thigh and thoracic musculature were recorded in most dead chickens. The toxic effect of sodium salinomycin started to manifest itself in 4-week-old chickens after sublethal dose of 20 mg.kg⁻¹ of b. w. (200 mg of preparation). Poisoning symptoms were very weak and disappeared after 15 h.
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