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Effects of the phosphodiesterase-4 inhibitor rolipram on lung resistance and inflammatory reaction in experimental asthma

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Nejman-Gryz P., Grubek-Jaworska H., Glapinski J., Hoser G., Chazan R.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 4

229-239

The aim of this study was to evaluate the influence of pretreatment with the phosphodiesterase-4 inhibitor rolipram on pulmonary resistance, influx of inflammatory cells, and histamine concentration in bronchoalveolar lavage fluid (BALF) during an experimental asthmatic reaction induced in ovalbumin (OA)-sensitized guinea pigs, challenged with OA inhalation. The experiment was performed in three groups of guinea pigs: two experimental groups, pretreated with rolipram or dexamethasone, and a control group without any pretreatment. Lung resistance (LR) was continuously recorded under suppression of spontaneous breathing during early asthmatic reaction. BALF was obtained before and at three time points up to 24 hr after the challenge. In the untreated, control animals a transient, significant increase in neutrophils, total and CD4+ lymphocytes, macrophages, eosinophils, and in histamine concentration in BALF was noted. Pretreatment with rolipram significantly reduced LR, eosinophils infiltration, and histamine release into the bronchoalveolar space during the early asthmatic reaction. These effects were generally comparable with those of dexamethasone, except that dexamethasone also reduced the influx of neutrophils into BALF.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology. Supplement

1 Chazan R.

1 Glapinski J.

1 Grubek-Jaworska H.

1 Hoser G.

1 Nejman-Gryz P.

1 2006

Wyniki wyszukiwania

Effects of the phosphodiesterase-4 inhibitor rolipram on lung resistance and inflammatory reaction in experimental asthma