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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Wpływ nawożenia mikroelementami (Fe, Mn i Cu) przy różnym pH gleby na zawartość kwasu askorbinowego beta-karotenu oraz innych karotenoidów w szpinaku (Z prac Zakładu Warzywnictwa SGGW)

100%
Ziemska J.
Postępy Nauki Rolniczej
|
1954
|
tom 01
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nr 6
2
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Tyrosine kinase, Aurora kinase and leucine aminopeptidase as attractive drug targets in anticancer therapy - characterisation of their inhibitors

63%
Ziemska J., Solecka J.
Roczniki Państwowego Zakładu Higieny
|
2016
|
tom 67
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nr 4
Cancers are the leading cause of deaths all over the world. Available anticancer agents used in clinics exhibit low therapeutic index and usually high toxicity. Wide spreading drug resistance of cancer cells induce a demanding need to search for new drug targets. Currently, many on-going studies on novel compounds with potent anticancer activity, high selectivity as well as new modes of action are conducted. In this work, we describe in details three enzyme groups, which are at present of extensive interest to medical researchers and pharmaceutical companies. These include receptor tyrosine kinases (e.g. EGFR enzymes) and non-receptor tyrosine kinases (Src enzymes), type A, B and C Aurora kinases and aminopeptidases, especially leucine aminopeptidase. We discuss classification of these enzymes, biochemistry as well as their role in the cell cycle under normal conditions and during cancerogenesis. Further on, the work describes enzyme inhibitors that are under in vitro, preclinical, clinical studies as well as drugs available on the market. Both, chemical structures of discovered inhibitors and the role of chemical moieties in novel drug design are discussed. Described enzymes play essential role in cell cycle, especially in mitosis (Aurora kinases), cell differentiation, growth and apoptosis (tyrosine kinases) as well as G1/S transition (leucine aminopeptidase). In cancer cells, they are overexpressed and only their inhibition may stop tumor progression. This review presents the clinical outcomes of selected inhibitors and argues the safety of drug usage in human volunteers. Clinical studies of EGFR and Src kinase inhibitors in different tumors clearly show the need for molecular selection of patients (to those with mutations in genes coding EGFR and Src) to achieve positive clinical response. Current data indicates the great necessity for new anticancer treatment and actions to limit off-target activity.
3
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Natural groundwaters in Poland - occurrence, properties and chemical types

51%
Ziemska J., Mazanska M., Szynal T., Solecka J.
Roczniki Państwowego Zakładu Higieny
|
2020
|
tom 71
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nr 4
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Natural medicinal resources and their therapeutic applications

51%
Ziemska J., Szynal T., Mazanska M., Solecka J.
Roczniki Państwowego Zakładu Higieny
|
2019
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tom 70
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nr 4
Natural medicinal resources are a country’s natural wealth. Natural medicinal waters, medicinal gases, and peloids have many properties that enable their use in the treatment of gastrointestinal, circulatory, respiratory, bone and joint, and skin and soft tissue disorders. Balneotherapy can be also applicable in prevention of many diseases and rehabilitation. At present, because there are several chemicals of synthetic origin, there is a need to search for nonpharmacological approaches and explore natural healing sources, which better fit the human body. Compared to synthetic drugs, these resources rarely show side effects, which increases the comfort of therapy. The use of natural medicinal resources in the form of treatments in health resort medicine centers under the supervision of balneologists, combined with the healing properties of the climate, contributes not only to the reduction of treatment time for many diseases but also to improvement of therapy’s results. The article discusses natural medicinal resources and some of their therapeutic applications.
5

Promieniowce - występowanie i wytwarzanie związków biologicznie czynnych

45%
Solecka J., Ziemska J., Rajnisz A., Laskowska A., Guspiel A.
Postępy Mikrobiologii
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2013
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tom 52
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nr 1
6

Secondary metabolites of actinomycetes and their antibacterial, antifungal and antiviral properties

45%
Jakubiec-Krzesniak K., Rajnisz-Mateusiak A., Guspiel A., Ziemska J., Solecka J.
Polish Journal of Microbiology
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2018
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tom 67
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nr 3
The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural producers of bioactive substances, Actinobacteria continue to be an important source of novel secondary metabolites for drug application. In this review, the authors report on the bioactive antimicrobial secondary metabolites of Actinobacteria that were described between 2011 and April 2018. Special attention is paid to the chemical scaffolds, biological activities and origin of these novel antibacterial, antifungal and antiviral compounds. Arenimycin C, chromopeptide lactone RSP 01, kocurin, macrolactins A1 and B1, chaxamycin D as well as anthracimycin are regarded as the most effective compounds with antibacterial activity. In turn, the highest potency among selected antifungal compounds is exhibited by enduspeptide B, neomaclafungins A-I and kribelloside D, while ahmpatinin i Bu, antimycin A1a, and pentapeptide 4862F are recognized as the strongest antiviral agents.
7

Characterization and optimization of biosynthesis of bioactive secondary metabolites produced by Streptomyces sp. 8812

39%
Rajnisz A., Guspiel A., Postek M., Ziemska J., Laskowska A., Rabczenko D., Solecka J.
Polish Journal of Microbiology
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2016
|
tom 65
|
nr 1
The nutritional requirements and environmental conditions for a submerged culture of Streptomyces sp. 8812 were determined. Batch and fed-batch Streptomyces sp. 8812 fermentations were conducted to obtain high activity of secondary metabolites. In the study several factors were examined for their influence on the biosynthesis of the active metabolites-7-hydroxy-6-oxo-2,3,4,6-tetrahydroisoquinoline-3-carboxyl acid (C₁₀H₉NO₄) and N-acetyl-3,4-dihydroxy-l-phenylalanine (C₁₁H₁₃NO₅): changes in medium composition, pH of production medium, various growth phases of seed culture, amino acid supplementation and addition of anion exchange resin to the submerged culture. Biological activities of secondary metabolites were examined with the use of dd-carboxypeptidase 64–575 and horseradish peroxidase. Streptomyces sp. 8812 mycelium was evaluated under fluorescent microscopy and respiratory activity of the strain was analyzed. Moreover, the enzymatic profiles of the strain with the use of Api®ZYM test were analyzed and genetic analysis made. Phylogenetic analysis of Streptomyces sp. 8812 revealed that its closest relative is Streptomyces capoamus JCM 4734 (98%), whereas sequence analysis for 16S rRNA gene using NCBI BLAST algorithm showed 100% homology between these two strains. Biosynthetic processes, mycelium growth and enzyme inhibitory activities of these two strains were also compared.
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