Wyniki wyszukiwania

1

Antioxidant activity: what do we measure?

100%

Bartosz G., Bartosz M.

Acta Biochimica Polonica

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1999

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tom 46

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nr 1

Inhibition of oxidation of 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) by free radicals generated by decomposition of 2,2'-azobis(2-amidopropane) (ABAP) by antioxidants and biological material was studied. A correlation was found between the ability of various substances to delay the onset of ABTS oxidation and their rapid reduction of the ABTS+* cation radical, and between the ability to reduce the maximal rate of ABTS oxidation and slow reduction of ABTS+*. The length of the lag period of ABTS oxidation was found to be independent of ABTS concentration. Similar decrease of peroxynitrite-induced ABTS+* formation by antioxidants was observed when the antioxidants were added before and after peroxynitrite. All these findings indicate that the main effect of antioxidants in this system is reduction of ABTS+* and not prevention of its formation. Reduction of oxidation products rather than inhibition of their formation may be the predominant mode of action of antioxidants in various assays of antioxidant activity.

2

Phagocytosis and killing of Listeria by guinea pig macrophages and neutrophils

81%

Rudnicka W., Dlugonska H., Bartosz M.

Archivum Immunologiae et Therapiae Experimentalis

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1988

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tom 36

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nr 2

3

There is no evidence for the existence of complex formation between doxorubicin and glutathione

80%

Marszalek M., Bartosz M., Bartosz G.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2

Doxorubicin is co-transported with glutathione by several multidrug resistance proteins (MRPs). In order to check whether weak non-covalent aggregates between doxorubicin and glutathione can be formed, which might be substrates for the transporter, the effect of glutathione on the partition coefficient of doxorubicin was studied. No evidence of an effect of glutathione (at levels up to 20 mM) on the partition coefficient of doxorubicin was found in the pH range of 4.0-7.4. These results indicate that non-covalent doxorubicin-glutathione complexes do not form.

4

The total antioxidant capacity of blood plasma during cardiovasculary bypass surgery in patients with coronary heart disease

61%

Kedziora-Kornatowska K., Bartosz M., Mussur M., Zaslonka J., Kedziora J., Bartosz G.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 4

We studied the effect of ischemia and reperfusion on the total antioxidant capacity (TAC) of blood plasma during cardiopulmonary bypass surgery employing the modified St. Thomas Hospital cardioplegic solution. TAC was determined using the FRAP method. TAC decreased during surgery, but no further decrease in TAC was observed during reperfusion, indicating that it is a relatively stable parameter of the antioxidative barrier of the body.

Ograniczanie wyników

2 Cellular and Molecular Biology Letters

1 Acta Biochimica Polonica

1 Archivum Immunologiae et Therapiae Experimentalis

4 Bartosz M.

3 Bartosz G.

1 Dlugonska H.

1 Kedziora J.

1 Kedziora-Kornatowska K.

1 Marszalek M.

1 Mussur M.

1 Rudnicka W.

1 Zaslonka J.

2 2003

1 1999

1 1988

Antioxidant activity: what do we measure?

Phagocytosis and killing of Listeria by guinea pig macrophages and neutrophils

There is no evidence for the existence of complex formation between doxorubicin and glutathione

The total antioxidant capacity of blood plasma during cardiovasculary bypass surgery in patients with coronary heart disease