Clinical, cardiovascular and respiratory effects of Bio- ketan-Biowet (ketamine 100 mg/ml) used alone and Bioketan supplemented by xylazine were compared in dogs. The duration of Bioketan (35 mg/kg, im) action was short, muscle tone and salivation were excessive and heart rate increased significantly. There was also psycho-motoral excitation during recovery time. These side effects were eliminated by a combination of xylazine-Bioketan (xylazine - 2.0 mg/kg, im and Bioketan - 20 mg/kg, im). With that composition the degree of muscle relaxation, level of sedation and analgesia were higher, stable surgical tolerance longer and tachycardia of a lower value than with Bioketan used separately. Parameters of ventilation and acid- -base balance were within physiological range all the time but the cardiac output (Ca-v02) decreased transiently and arterial blood pressure increased at the beginning of anaesthesia. A composition of Bioketan with xylazine thoroughly relaxed muscle action and allowing the reduction of the drug doses and therefore making anaesthesia infusion safer.
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