The aim of the study was to evaluate the efficacy of aglepristone - a progesterone receptor blocker - in the treatment of endometritis-pyometra complex (EPC) in bitches. 12 bitches of pure and mixed breeds between 2 and 13 years of age with EPC were examined. All animals were treated according to the same pattern: aglepristone (Alizine, Virbac®) was administered at the dose of 0.33 ml/kg, s.c. on days 1, 2, 7, and 14. Additionally, the antibiotic amoxycyline (Clamoxyl, Pfizer®) was administered at the dose of 1 ml/10 kg, s.c. every 48 hours for 10 days. A complete puss mass elimination, uterus involution and improvement of clinical state were observed after 3 weeks of treatment. Progesterone concentration, that was highly increased at the beginning of treatment, decreased to low levels during its first week. The leukocyte count (WBC), alkaline phosphatase (AP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) exceeded normal values before and in the first days of treatment. These parameters improved to normal values after the first week of treatment. The recurrence of EPC was not observed in any bitch during the next 2 years. Three bitches were mated in next heats but did not get pregnant. In the present study the antigestagens therapy proved highly effective: clinical recovery and the recurrence of normal haematological and biochemical counts were observed.
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