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The studies were carried out on 8 horses including two controls. Three nimals were given E. coli endotoxin twice at 24-hour intervals intravenously in a dose of 1.0 (ig/kg of body weight. The other three received the endotoxin 3 times in doses of 0.2 pg and 0.1 pg (after 3 hours) and 0.2 pg after 24 hours. In all six horses the signs of endotoxaemia of a different extent were observed. In the first group (3 horses) only insignificant statistical alterations were noticed regarding blood coagulation indices, while in the second group significant disturbances were found, i.d. a decrease in the number of thrombocytes, an increase of fibrinogen concentrations, the prolongation of the prothrombin and, in some animals, also of coalin-kep- halin times and a drop of AT III activity that indicate the occurrence of DIC syndrome.
The aim of the study was to estimate coagulation parameters during pregnancy and parturition in goats. Examinations were carried out on 20 Polish White goats, and blood was obtained five times from the jugular vein: before insemination, in the second, fourth and fifth months of pregnancy and 24 hours following parturition. TT and AT III did not change significantly during the entire experiment, however PT and APTT were significantly prolonged following parturition and increased levels of fibrinogen and D-dimer were noted
The coagulation system, which is responsible for maintaining an organism’s hemostasis, is present in all mammals; nevertheless, there are differences in the dynamics of processes of coagulation activation and fibrinolysis in individual species. In horses, the development of hemostasis processes is different at all stages in comparison to humans. Primary hemostasis is maintained at a relatively low number of thrombocytes with coexisting differences in the structure and morphology of blood platelets. For many years, primary hemostasis has been determined solely on the basis of coagulation time; currently, lumiagregometry or impedance aggregation is used. New techniques and technologies allow an ever broader view of the pathogenesis of many diseases in terms of the coagulation system’s abnormalities, which either stand for an etiologic factor or only accompany the disease (they are its result). In the course of horse colic, especially in acute and recurrent forms, there are several changes in the parameters of the hemostatic system. It is believed that DIC is the most common coagulopathy. However, there is are no definite life-extending criteria as well as postmortem diagnosis of this syndrome. Changes in blood rheology after exercise are primarily due to an increase in hematocrit. The impact of exercise on the coagulation system in horses was analyzed, and showed a tendency in EPIH horses for the occurrence of hypercoagulability with the prolongation of blood coagulation parameters. The role and the contribution of the coagulation system in the etiopathogenesis of equine laminitis is not clear; in the case of carbohydrate overdosage microtrombosis, reduced platelet survival and their over-aggregation have been reported. Clinical studies in sick animals show that coagulopathy such as DIC and antithrombin deficiency are not primary factors in the etiopathogenesis of laminitis.
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