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The article reviews the occurrence of Schmallenberg disease in Europe from 2011 to September 2013. The first cases of disease caused by Schmallenberg virus (SBV) were reported in Germany and the Netherlands in the late summer/autumn of 2011 in adult dairy cows displaying hyperthermia, drop in milk production and diarrhea. In November 2011, by means of a metagenomic approach, for the first time the Friedrich-Löeffler Institute (Germany) detected viral RNA belonging to a new virus in blood samples from clinically affected dairy cows. This new virus was called Schmallenber virus after the place of origin of the collected samples. Phylogenetic analysis revealed that SBV belongs to the genus Orthobunyavirus within the family Bunyaviridae. Ortobunyaviruses are widely distributed in the world; mainly in Asia, Africa, Australia and Oceania, in tropical and subtropical areas, with a warm and humid climate. Their occurrence depends primarily on the presence of Culicoides spp. vector and a reservoir for the virus, which are diseased and infected animals. In Europe, since the first cases of SBV infection in 2011 until September 2013 the presence of SBV or specific antibodies were detected in 27 European countries, including twenty three EU Member States (Austria, Belgium, Czech Republic, Croatia, Denmark, Estonia, Finland, France, Hungary, Germany, Ireland, Italy, Latvia, Lithuania, Luxembourg, The Netherlands, Poland, Romania, Slovenia, Spain, Sweden, United Kingdom and Greece) and four non-Member States (Switzerland, Norway, Russia and Serbia). SBV infection was detected mainly in cows and sheep, in 5636 and 2922 farms, respectively. SBV has since been detected in approximately 9000 farms; the most being found in France (4557) and Germany (2046).
The Schmallenberg virus (SBV), as a new for Europe Ortobuniaviridae genus member, emerged in Poland in 2012, spreading rapidly across the country. Serological monitoring revealed a continuous increase of seropositivity among farm ruminants; moreover, the virus was detected in the insect vector, i.e. biting midges in different regions. The sylvatic cycle of SBV infections cannot be ruled out due to the detection of SBV antibodies in 24% of free living ruminants. Breeding losses related to SBV infection are difficult to estimate because of the lack of regulations for mandatory notifications. Furthermore specific symptoms associated with congenital malformations in newborns are observed only in a small percentage of intrauterine infections. Due to the current restrictions or bans on the export of animals resulting from SBV infection significant economic losses are recorded. The emergence of a new, never previously detected in Europe arbovirus raises a number of questions about its manner of transmission, vector ecology, the possibility of its spread and prevention as well as control of the diseases.
The aim of this paper is to summarize and present the most recent data concerning the new emerging disease caused by the so-called Schmallenberg virus, which is spreading to new European countries. The disease has already been reported in Germany, Great Britain, the Netherlands, France, Spain, Denmark and Switzerland, and more cases are being reported in different regions of these countries each month. The appearance of the virus has resulted in restrictions on the import of live animals, semen and embryos to currently virus-free countries (Russia, Kazakhstan, Belarus, Ukraine, Turkey, Egypt, Kuwait, Lebanon, Algeria, Jordan, Morocco, Japan, Mexico, Argentina and the USA). The virus belongs to the Simbu-group viruses and is believed to be transmitted by vectors (midges, Culicoides). The infection is mild in adult animals (diarrhea, pyrexia, a decrease in milk yield), but causes abortions and fetal malformations (arthrogryposis, brachygnatia inferior, hydrocephalus). Although the Schmallenberg virus infection may result in economic losses, no vaccine has yet been developed. Because of its status as a new emerging disease and its dynamic development, the spread of the disease and the evolution of its epidemiology must be closely monitored and instantly reported.
The article describes the major findings concerning the occurrence of previously unrecognized infection with a virus provisionally named “Schmallenberg virus” (SBV) in Germany, the Netherlands, Belgium and Great Britain. The virus belongs to the family Bunyaviridae, genus Orthobunyavirus, serogroup Simbu. Full-length genome sequencing has shown its highest genetic similarity to Shamonda and Akabane viruses. The viruses of this group are transmitted mainly by mosquitoes (Culicidae) and midges (Culicoides) with very limited direct transmission from animal to animal (mostly transplacental transmission from a dam to the foetus during pregnancy). The clinical manifestation of the Schmallenberg virus infection has been associated with non-specific clinical signs in adult cattle (fever, reduced milk yield, diarrhoea), whereas congenital malformations (hydrocephalus with brain hypoplasia, arthrogryposis) have been observed in newborn lambs. For diagnostic purposes, RT-PCR, virus neutralisation and indirect immuno-fluorescence tests have been developed. The latter two assays cannot be applied for large-scale testing, but an assay for serological screening is currently unavailable. The major conclusion of the preliminary risk assessment performed by the European Centre for Disease Prevention and Control (ECDC) is that the threat to human health is very unlikely but cannot be excluded at this stage. None of the infections caused by the viruses of the Simbu serogroup are included in the list of diseases subjected to international notification, but affected countries have notified OIE of the occurrence of SBV infections according to regulations applicable to new and emerging diseases.
The first clinical cases of Schmallenberg virus infection diagnosed in a dead calf and five aborted lambs from flocks in north-western Poland between November 2012 and January 2013 are described. An epizootic investigation made it possible to determine that an SBV infection, which resulted in the first clinical case in the cattle herd from the West Pomerania, probably occurred in the spring of 2012. In most cases the presence of viral RNA was confirmed in the brain, cerebellum, medulla and spleen of animals. All mothers of SBV infected neonates had specific antibodies. Arthrogryposis and cartridge deformations, brachygnathia inferior, kyphosis and torticollis were the most common defects. Macroscopic changes of the cranial region included hydranencephaly, porencephaly, hypoplasia to atrophy of hindbrain. Histopathological examination of brain tissue revealed vacuolation and hypoplasia of neuropil and the presence of lymphohistiocytic perivascular infiltration, hypereosinophilic, necrotic neurons and microglial nodules. Focal hypoplasia to atrophy of white matter and mild hypoplasia of the gray matter was also observed.
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