Wyniki wyszukiwania

1

Solute-free water retention in preascitic cirrhotic rats following intravenous water loading

100%

Sansoe G., Aragno M., Smedile A., Rizzetto M., Rosina F.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

111-117

Increased extracellular fluid volume (ECF) characterizes compensated cirrhosis. To identify the mechanisms of fluid retention in cirrhosis through clearance methods, 10 control and 10 preascitic rats with CCl4-induced cirrhosis were studied following i.v. loading with 1 ml 5% glucose solution. Glomerular filtration rate and renal plasma flow were evaluated through inulin and para-aminohippurate clearances; water and electrolyte handling was assessed measuring urine and plasma osmolarity, electrolyte excretions, and tubular solute-free water reabsorption (TFWR = osmolar clearance minus urinary output); ECF was assessed through hormonal status determination. After water loading, cirrhotic rats had increased ECF (lower plasma renin activity and aldosterone and higher atrial natriuretic peptide levels, all P<0.03), solute-free water retention (increased TFWR and decreased plasma osmolarity, all P<0.05), reduced absolute and fractional sodium excretions (P<0.05). Cirrhotic rats showed sodium retention in the medullary thick ascending limb of Henle’s loop (i.e. increased values of TFWR for any given value of osmolar clearance). Trans-tubular potassium gradient in medullary collecting duct was similar in the two groups (P=0.55), ruling out aldosterone-dependent sodium retention and potassium hyper-secretion. In experimental preascitic cirrhosis NaCl retention in the ascending limb of Henle’s loop increases medullary interstitial tonicity leading to vasopressin-independent water back-diffusion in thin descending limb of Henle’s loop and collecting duct.

2

Centrally administered galanin modifies vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of euhydrated and dehydrated rats

84%

Ciosek J., Cisowska A.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 4

Galanin (Gal) as a neuropeptide with widespread distribution in the central nervous system may be involved in the mechanisms of vasopressin (AVP) and oxytocin (OT) release from the hypothalamo-neurohypophysial system. Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats. In not dehydrated rats intracerebroventricular (i.c.v.) injections of Gal did not affect the hypothalamic and neurohypophysial OT content, however, distinctly increased plasma OT concentration. In the same animals Gal diminished the hypothalamic AVP content but was without the effect on neurohypophysial AVP storage; plasma AVP level then raised. Galanin, administered i.c.v. to rats deprived of water, distinctly inhibited AVP and OT release from the hypothalamo-neurohypophysial system. Simultaneously, plasma AVP and OT level was significantly diminished after Gal treatment in dehydrated rats. These results suggest that modulatory effect of galanin on vasopressin and oxytocin release depends on the actual state of water metabolism. Gal acts as an inhibitory neuromodulator of AVP and OT secretion under conditions of the dehydration but stimulates this process in the state of equilibrated water metabolism.

3

Water physiology and population dynamics in insular populations of Mastsomys huberti [Rodentia, Muridae]

84%

Granjon L., Ganem G., Ba K., Duplantier J. M.

Polish Ecological Studies

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1994

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tom 20

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nr 3-4

4

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A method for measurements of hydraulic conductivity of biological membranes in vitro

67%

Knapowski J.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 1

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Polish Ecological Studies

1 Aragno M.

1 Ba K.

1 Ciosek J.

1 Cisowska A.

1 Duplantier J. M.

1 Ganem G.

1 Granjon L.

1 Knapowski J.

1 Rizzetto M.

1 Rosina F.

1 Sansoe G.

1 Smedile A.

1 2009

1 2003

1 1997

1 1994

Solute-free water retention in preascitic cirrhotic rats following intravenous water loading

Centrally administered galanin modifies vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of euhydrated and dehydrated rats

Water physiology and population dynamics in insular populations of Mastsomys huberti [Rodentia, Muridae]

A method for measurements of hydraulic conductivity of biological membranes in vitro