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Do shape transformations in erythrocytes reflect the flip rate of amphiphilic compounds?

100%

Hagerstrand H., Bobrowska-Hagerstrand M., Isomaa B.

Cellular and Molecular Biology Letters

1996

tom 01

nr 1

It has been shown that the time course of echinocyte to discocyte transformation caused by exogenous phospholipids is an accurate measure of the flip rate of the phospholipids in the lipid bilayer [1,2]. In order to explore whether shape changes in erythrocytes are indicative of flip rates of water- soluble amphiphiles, the time course of shape changes caused by a large number of amphiphiles was studied. In case of amphiphiles inducing echinocyte to discocyte or discocyte to stomatocyte transformation it is proposed that the time course of shape transformation may be indicative of the flip rate of the amphiphiles. The relevance of using shape changes in erythrocytes as a tool to estimate flip rates of amphiphiles is discussed.

Erythrocytes vesiculate at high pH

100%

Bobrowska-Hagerstrand M., Iglic A., Hagerstrand H.

Cellular and Molecular Biology Letters

1997

tom 02

nr 1

Human erythrocytes were incubated at alkaline pH. In samples equilibrating within 60 min to pH 11 erythrocytes underwent prelytic vesiculation (fragmentation). Erythrocytes developed large (diameter often 1-2 µm) hemoglobin-filled blebs which could be released to the outer medium as hemoglobin containing vesicles. It is suggested that the described vesiculation at high pH occurs due to an uncoupling of the membrane skeleton from the lipid bilayer. Due to the uncoupling from the skeleton the erythrocyte lipid bilayer may behave similar to the membrane of a giant lipid vesicle.

Vesiculation of food vacuoles and segregation of ingesta: peculiarities of the digestive cycle in the raptorial ciliate Homalozoon vermiculare

80%

Baumberg D., Hausmann K.

Acta Protozoologica

2007

tom 46

nr 1

Ograniczanie wyników

2 Cellular and Molecular Biology Letters

1 Acta Protozoologica

2 Bobrowska-Hagerstrand M.

2 Hagerstrand H.

1 Baumberg D.

1 Hausmann K.

1 Iglic A.

1 Isomaa B.

1 2007

1 1997

1 1996

Wyniki wyszukiwania

Do shape transformations in erythrocytes reflect the flip rate of amphiphilic compounds?

Erythrocytes vesiculate at high pH

Vesiculation of food vacuoles and segregation of ingesta: peculiarities of the digestive cycle in the raptorial ciliate Homalozoon vermiculare