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Influence of the new benzodiazepine derivative BD-1158 on the behaviour of rabbits under stress conditions

100%

Cygan B., Wojcik G., Czabak-Garbacz R., Teter M., Kozlovsky I.

Bulletin of the Veterinary Institute in Puławy

2001

tom 45

nr 2

BD-1158 is a new 1,4 benzodiazepine derivative. The purpose of the present experiments was to test the influence of this substance on the behaviour of rabbits under stress conditions, induced by electrical stimulation of ventromedial nucleus of the hypothalamus (VMH). The experiments were performed for 4 subsequent days in a group of 10 rabbits. On the first day the electrode was implanted into VMH. On the second day the spontaneous behaviour in stress conditions was tested. On the third day 1 ml of 1 % starch solution was administered intraperitoneally. On the fourth day BD-1158 was administered intraperitoneally at a dose 10mg/kg diluted in starch solution up to 1 ml, 35 minutes before the beginning of the experiment. Six phases of behaviour were estimated. It was concluded that in extreme conditons BD-1158 has a strong anxiolytic and sedative effect. lts influence concerns a considerable extension of the comfort phase and decrease of the tension phase. BD-1158 does not influence the animals' activity and attention (the orientation-searching phase and grooming). It decreases eating and drinking.

Ultrastructure of the ventromedial hypothalamic nucleus in fasted and refed young and old rats

67%

Kubasik-Juraniec J., Kmiec Z., Tukaj C., Adamowska A., Kotlarz G., Pokrywka L., Mysliwski A.

Folia Morphologica

2003

tom 62

nr 2

Many hypothalamic nuclei are involved in the regulation of food intake and energy homeostasis. An ultrastructural investigation of the hypothalamic ventromedial nucleus (VMN), a hypothetical “satiety centre” was performed to explore the morphological basis of altered feeding behaviour of old rats in an experimental model of fasting/refeeding. Young (5 months old, n = 12) and old (24 months old, n = 12) male Wistar rats were fasted for 48 hours, then refed for 24 hours and sampled thereafter. Brain tissue was fixed by perfusion, histological and ultrathin sections were obtained by routine methods. Although food intake was similar in control young and old rats, during refeeding old animals consumed less chow than young ones. The EM analysis of VMN neurones of old control rats revealed, besides typical age-related residual bodies, deep indentations of the nuclear envelope and the presence of long, undulating rough endoplasmic reticulum cisternae in the cell periphery. In both young and old rats fasting for 48 hours led to the expansion of Golgi complexes and increased folds of the nuclear envelope, which is suggestive of enhanced cellular activity of the VMN neurones. These fasting-induced alterations were sustained in the VMN neurones of refed rats in both age groups. The results showed that the VMN neurones of old control rats differ at the ultrastructural level from young ones. However, starvation and subsequent refeeding cause similar alterations in the hypothalamic neurones of “satiety centre” of both young and old rats.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Folia Morphologica

1 Adamowska A.

1 Cygan B.

1 Czabak-Garbacz R.

1 Kmiec Z.

1 Kotlarz G.

1 Kozlovsky I.

1 Kubasik-Juraniec J.

1 Mysliwski A.

1 Pokrywka L.

1 Teter M.

1 Tukaj C.

1 Wojcik G.

1 2003

1 2001

Wyniki wyszukiwania

Influence of the new benzodiazepine derivative BD-1158 on the behaviour of rabbits under stress conditions

Ultrastructure of the ventromedial hypothalamic nucleus in fasted and refed young and old rats