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1
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Influence of vagal nerve stimulation on food intake and body weight - results of experimental studies

100%
Sobocki J., Krolczyk G., Herman R. M., Matyja A., Thor P. J.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 6
27-33
The paper reviews recent advances in vagal nerve stimulation for the control of food intake and body weight. The vagal nerves are the predominant pathway in the "brain-gut axis" responsible for short term regulation of food intake. Stimulation of afferent vagal traffic attenuates food intake by vagal projections to nucleus tractus solitarius, arcuate nucleus and its convergence’s to thalamic center of satiety. A few studies have been published in this field so far. All of them are consistent and show significant decrease in body mass during vagal stimulation. Due to promising results of experimental studies, clinical trials are expected in the near future.
2
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Effect of long-term vagal stimulation on food intake and body weight during diet induced obesity in rats

100%
Bugajski A. J., Gil K., Ziomber A., Zurowski D., Zaraska W., Thor P. J.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 1
5-12
3
Content available remote

Magnetically induced vagus nerve stimulation and feeding behavior in rats

100%
Ziomber A., Juszczak K., Kaszuba-Zwoinska J., Machowska A., Zaraska K., Gil K., Thor P.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 3
71-77
Vagus nerve (VN) contribute to the bidirectional communication between the gastrointestinal tract and the central nervous system. Stimulation of the VN by a magnetically-driven solenoid with parameters similar to those during food-induced stomach distension has been thought to mimic short-term signaling of satiety and suppress food intake. In this study, the determination of optimal parameters of vagal neuro-modulation to achieve decreased food intake with a resulting reduction in body mass of rats is explored as therapy to treat obesity. The experimental design consisted of three groups of obese adult male Wistar rats: Group 1: VEMF - with solenoid's electrodes placed on the left VN in the magnetic field exposure (MFE); Group 2: EMF - without solenoid's electrodes on the VN in MFE; Group 3: CON - without solenoid's electrodes on the VN outside the MFE. This study suggests that the rats with solenoid's electrodes placed on the left VN significantly decreased their food intake, weight gain and serum leptin concentrations when compared to that of the CON group. PP levels were found to be higher in the VEMF group when compared to the controls groups. It was found that the most effective parameters of vagal stimulation on eating behavior were 3631, 7861, 14523 A2 x h/m2. The magnetic field by unknown mechanisms also influences feeding behavior. This study suggests that vago-vagal reflexes are involved in the feeding homeostasis and that neuromodulation might be an effective method for managing obesity. Further studies are required to confirm these effects in humans.
4
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Effects of vagal neuromodulation and vagotomy on control of food intake and body weight in rats

100%
Laskiewicz J., Krolczyk G., Zurowski D., Sobocki J., Matyja A., Thor P. J.
Journal of Physiology and Pharmacology
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2003
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tom 54
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nr 4
Food induced neurohumoral signals are conduced to data processing brain centers mainly as vagal afferent discharge resulting in food intake regulation. The aim of this study was to evaluate effects of vagal nerve neuromodulation in control of food intake with fed-pattern microchip (MC) pacing. Experiments were performed on 60 rats divided on 5 groups: I group 0,05Hz left vagal pacing, II - pacing of both vagal nerves with MC 0,05Hz, III- left vagal MC 0,1Hz pacing, IV - pacing of both vagal nerves with MC 0,1 Hz was performed. In group V left vagal pacing was combined with right side abdominal vagotomy. Body weight and total food intake decreased by 12% and 14% (I), 26% and 30%(II), 8% and 21%(III), 14% and 30%(IV), 38% and 41%(IV), respectively (p<0.05). Effects of both vagal nerves stimulation on final body weight and food intake was significantly more effective than only single nerve MC pacing however most effective was stimulation with 0,1Hz combined with right vagotomy. We conclude that vagal stimulation reduce food intake and body weight by increasing vagal afferent signals. Our results suggest that information in vagal afferents can be modulated resulting in changes of feeding behaviour and body weight.
5
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Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet

80%
Gil K., Bugajski A., Thor P.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 6
6
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Physiological and morphological effects of long-term vagal stimulation in diet induced obesity in rats

70%
Gil K., Bugajski A., Kurnik M., Zaraska W., Thor P.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
|
nr 3
61-66
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