The aim of the study was to estimate the uterus involution and progesterone level after antigestagene therapy in 12 bitches with a closed form of endometritis-pyometra complex (EPC). The bitches were of pure and mixed breeds, between 2 and 13 years of age. All the animals were treated with the same pattern: aglepristone was administrated at the dose of 0.33 mL/kg, s.c. on days 1, 2, 7, and 14. Additionally, amoxycyline was given at the dose of 1 mL/l0kg, s.c. every 48 h for 10 d. Complete elimination of puss masses and uterus involution were observed after 7-14 d of the treatment. Progesterone concentration was highly increased at the beginning of the treatment and was decreasing to low values during the first week of the therapy. Detectable uterus changes in the USG examination and physiological health status are not the only recovery criteria, but, most importantly, lack of recurrence of the EPC and the ability to deliver healthy progeny.
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