Wyniki wyszukiwania

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Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

100%

Li H., Tong S., Liu J., Han L., Yang X., Hou H., Yan Q., Wang X.-Q.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 2

Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.

2

Hsp27 expression in invasive ductal breast carcinoma

84%

Grzegrzolka J., Kurnol K., Piotrow P., Pula B., Kobierzycki C., Piotrowska A., Jablonska K., Wojnar A., Rys J., Dziegiel P., Podhorska-Okolow M.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 4

3

Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy

84%

Nowak M., Dziegiel P., Madej J., Ugorski M.

Folia Histochemica et Cytobiologica

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2013

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tom 51

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nr 2

4

Intensity of COX2 expression in cells of soft tissue fibrosarcomas in dogs as related to grade of tumour malignancy

84%

Nowak M., Madej J. A., Dziegiel P.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 2

Using imunohistochemical technique, localisation and intensity of COX2 expression were estimated in canine soft tissue fibrosarcomas. The obtained results were related to tumour grade of malignancy. The material was sampled in the course of surgery from 23 dogs of various breed, 5 to 18 years of age. The presence of COX2 was demonstrated in cell cytoplasm in over 43% tumours. Augmented expression of COX2 was observed in samples of tumours manifesting higher grade of malignancy. Also strong positive correlation was detected (r=0.76) between expression of COX2 and grade of malignancy in the tumours, which might point to the involvement of the enzyme in neoplastic transformation of the cells from which fibrosarcomas derive in dogs.

Ograniczanie wyników

2 Folia Histochemica et Cytobiologica

1 Bulletin of the Veterinary Institute in Puławy

1 Cellular and Molecular Biology Letters

3 Dziegiel P.

2 Nowak M.

1 Grzegrzolka J.

1 Han L.

1 Hou H.

1 Jablonska K.

1 Kobierzycki C.

1 Kurnol K.

1 Li H.

1 Liu J.

1 Madej J.

1 Madej J. A.

1 Piotrow P.

1 Piotrowska A.

1 Podhorska-Okolow M.

1 Pula B.

1 Rys J.

1 Tong S.

1 Ugorski M.

1 Wang X.-Q.

1 Wojnar A.

1 Yan Q.

1 Yang X.

1 2013

2 2012

1 2007

Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

Hsp27 expression in invasive ductal breast carcinoma

Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy

Intensity of COX2 expression in cells of soft tissue fibrosarcomas in dogs as related to grade of tumour malignancy