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1

Use of microporous hydroxyapatite material in regenerative treatment of periodontal tissues in dogs: a clinical study

100%
Polkowska I., Slosarczyk A., Sobczynska-Rak A., Golynska M., Szponder T., Zylinska B.
Medycyna Weterynaryjna
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2018
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tom 74
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nr 12
One of the biomaterials used in veterinary dentistry is hydroxyapatite (HAp). It aids the biological process of bone reconstruction and provides the basis on which damaged tissues can be rebuilt. It is also exceptionally osteoconductive and bioactive towards bone and other tissues. The aim of the present study was to verify the usefulness of hydroxyapatite microporus ceramics for the treatment of periodontal diseases and post-extraction defects. The study was performed on 40 dogs. Dogs were qualified for the in vivo test: 2 study groups and 2 control groups (K1, K2) were created. Group G1 comprised 10 dogs diagnosed with periodontitis with 4-8 mm gingival pockets and mobility of mandibular/maxillary incisors. In order to avoid extraction, hydroxyapatite implantation into the bone pockets was performed. Group G2 comprised 10 dogs that required the extraction of maxillary canines, following which biomaterial was introduced into the post-extraction cavities. Control groups were performed without using of microporous hydroxyapatite. In group G1, animals displayed significant shallowing of gingival pockets. The mean depth of pockets was significantly reduced in those dogs and considerably better reconstruction of periodontal tissues was observed when compared to the control group K1. In group G2, significantly faster healing of bone cavities was stated when compared to the respective control group K2. The study confirmed the validity of using microporous hydroxyapatite granules and shaped blocks in reconstructive periodontal treatment as well as prevention of oronasal fistulas after canines extraction and facilitation of the post-extraction healing process.
2

Effect of laser biostimulation on cell proliferation in the healing of cutaneous surgical wounds in pigs

84%
Chyczewski M., Rozicka A., Mikolajczyk A., Rotkiewicz T., Holak P., Jalynski M., Rotkiewicz Z.
Bulletin of the Veterinary Institute in Puławy
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2010
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tom 54
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nr 2
217-221
The objective of this study was to investigate the effect of low-level laser therapy (LLLT) on the proliferation of epithelial and connective tissue cells in the healing of incised cutaneous wounds in pigs. The experiment was conducted on 12 young pigs divided into four groups. Group I (undamaged skin) and group III (damaged skin) served as control. Group II - pigs with undamaged skin and group IV - pigs with incised wounds in the dorsal area were subjected to laser irradiation. Laser biostimulation was carried out using a CTL 1106 MX semiconductor laser in the continuous wave mode of operation at a wavelength of 810 nm and a maximum output of 100 mW. Following three weeks of observation, skin specimens were collected for histopathological analysis (HE), immunohistochemical detection of PCNA, and determination of apoptosis (TUNEL) and presence of mast cells (toluidine blue staining). Laser irradiation administered at E=8 J/cm for 1 min over a period of three weeks accelerated the proliferation of stratum basale cells, stimulated fibroblast proliferation, increased the number of mast cells in the wound area, and inhibited apoptosis in cells participating in the skin regeneration process.
3

Ewa Petru i Rudolf Retovsky: Rostlinne Explanaty. Nakladatelstvi Ceskoslovenske Akademie Ved, Praha 1956

67%
Niwelinski J.
Wszechświat
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1957
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nr 01
4

Hybrid cells differentiate to hepatic lineage cells and repair oxidative damage

67%
Xu D., Wang F., Gu H., Wang J., Guo Q., Zhang Y., Wang Z.
Cellular and Molecular Biology Letters
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2010
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tom 15
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nr 3
451-472
Hybrid cells derived from stem cells play an important role in organogenesis, tissue regeneration and cancer formation. However, the fate of hybrid cells and their range of function are poorly understood. Fusing stem cells and somatic cells induces somatic cell reprogramming, and the resulting hybrid cells are embryonic stem cell-like cells. Therefore, we hypothesize that fusion-induced hybrid cells may behave like ES cells in certain microenvironments. In this study, human hepatic cells were induced to apoptosis with H2O2, and then co-cultured with hybrid cells that had been derived from mouse ES cells and human hepatic cells using a transwell. After co-culturing, the degree of apoptosis was evaluated using Annexin-V/PI double-staining analysis, flow cytometry and Western-blot. We observed that H2O2-induced cell apoptosis was inhibited by co-culture. In addition, the activity of injury-related enzymes (GSH-Px, LDH and SOD) and the level of albumin release in the co-culture system trended toward the level of normal undamaged hepatic cells. The stably increased levels of secretion of ALB in the co-culture system also confirmed that co-culture with hybrid cells helped in recovery from injury. The fate of the hybrid cells was studied by analyzing their gene expression and protein expression profiles. The results of RT-PCR indicated that during co-culturing, like ES cells, hybrid cells differentiated into hepatic lineage cells. Hybrid cells transcripted genes from both parental cell genomes. Via immunocytochemical analysis, hepatic directional differentiation of the hybrid cells was also confirmed. After injecting the hybrid cells into the mouse liver, the GFP-labeled transplanted cells were distributed in the hepatic lobules and engrafted into the liver structure. This research expands the knowledge of fusion-related events and the possible function of hybrid cells. Moreover, it could indicate a new route of differentiation from pluripotent cells to tissue-specific cells via conditional co-culture.
5
Content available remote

Pathophysiology of ageing

67%
Knapowski J., Wieczorkowska-Tobis K., Witowski J.
Journal of Physiology and Pharmacology
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2002
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tom 53
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nr 2
Ageing is characterized by a gradual decline in organ functional reserves which reduces the ability to maintain homeostasis under conditions of stress. Introduction of cell culture and molecular biology techniques has provided new experimental tools for the analysis of ageing at the molecular level. During ageing progressive degeneration of cells and loss of regenerative capacity are enhanced and with time the alterations caused by them ultimately lead to death. In this paper the current knowledge of the mechanisms of ageing is summarized.
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