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1

The effect of the type and amount of fat in diet on the composition of fatty acids in tissue lipids in experimental hypercholesterolaemia

100%
Ziemlanski S., Budzynska-Topolowska J., Rodkiewicz B.
Żywienie Człowieka i Metabolizm
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1991
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tom 18
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nr 4
The efects were studied of the quality and amount of dietary fat on the pattern of fatty acids in the lipids of the serum and certain tissues (adipose fat, perirenal fat, liver, heart, testes) of guined pigs during experimentally induced hypercholesterolemia. During 12 weeks the animals received experimental diets containg 10% or 20% of energy from animal fats (butter, lard 2:3), sunflower oil or low-erucic rapeseed oil. Two control groups were chosen, receiving diets for animals without cholesterol or with 0.1% cholesterol added. The addition of cholesterol to the diet raised the content of the essential unsaturated fatty acids and polyunsaturated fatty acids in the adipose fat and hepatic lipids, and decreased their content in myocardial lipids. In testicular lipids changes were noted in the synthesis of long-chain polyunsaturated fatty acids. The addition of vegetable fats to the diet increased the content of linoleic acid in these tissues with a simultaneous decrease of arachidonic acid synthesis. It may be supposed that there is an upper range of arachidonic acid synthesis in the lipids of the studied tissues independent of dietary EFA and PUFA value.
2
Content available remote

Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation

67%
Dobrzyn A., Dobrzyn P.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 10
31-42
Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are a major component of tissue lipids. SCD1 deficient mice reveal increased energy expenditure and decreased body adiposity due to the upregulation of genes of fatty acid oxidation and the downregulation of genes of lipid synthesis in liver. In this review, we examine data showing that SCD is an important component in the regulation of skeletal muscle metabolism, which affects insulin sensitivity, mitochondrial fatty acid oxidation and ceramide de novo synthesis in oxidative myofibers. The lack of SCD1 gene increases the rate of fatty acid ß-oxidation through activation of the AMP-activated protein kinase (AMPK) pathway and by upregulating genes of fatty acid oxidation in soleus and red gastrocnemius muscles. Consistent with increased ß-oxidation, the contents of free fatty acids and long-chain acyl-CoAs are significantly decreased, which together with reduced mRNA level and activity of serine palmitoyltransferase led to reduced ceramide synthesis in oxidative muscles of SCD1-/- mice. Thus, reduced contents of free fatty acids, acyl-CoAs and ceramides as well as increased AMPK phosphorylation, might contribute to increased insulin sensitivity observed in muscle of SCD1-/- mice. SCD1 deficiency also results in downregulation of the expression of the protein-tyrosine phosphatase 1B, which is responsible for the sustained insulin receptor autophosphorylation despite reduced levels of plasma insulin in the SCD1-/- mice. SCD1 deficiency reduced ceramide synthesis, increased AMPK phosphorylation and carnitine palmitoyltransferase 1 activity also in soleus and red gastrocnemius muscles of leptin deficient ob/ob mice. These findings raise the possibility that SCD1 may be a downstream component of the leptin signaling pathway in skeletal muscle.
3

Low alpha-linolenic acid linseed oil affects hormones level and lipid metabolism in rat

59%
Chichlowska J., Kliber A.
Acta Scientiarum Polonorum. Medicina Veterinaria
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2002
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tom 01
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nr 1
4
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Unsaturated trans fatty acid - nutritional problem?

51%
Bartnikowska E., Obiedzinski M.
Polish Journal of Food and Nutrition Sciences
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1997
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tom 06
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nr 3
This review summarizes the up-to-date data on the consumption pattern of trans fatty acids in different countries including Poland, as well as the metabolism and metabolic effects of trans fatty acids in human organism. The health hazards linked with the consumption of trans fatty acids are also discussed.
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